Alcohol drinking and risk of subsequent hospitalisation with pneumonia

Abstract

The dose-response relationship between alcohol consumption and pneumonia risk in healthy individuals is poorly understood.We examined 22,485 males and 24,682 females from Denmark who were aged 50-64 yrs. Subjects were without major chronic diseases at baseline and had a median follow-up of 12 yrs for first-time hospitalisation with pneumonia.1,091 (males) and 944 (females) had pneumonia-related hospitalisation. Among males, the risk of pneumonia was increased for alcohol abstainers and those who drank large weekly amounts. The adjusted hazard ratios (HRs) for 0, . The association between high alcohol intake and pneumonia persisted after controlling for subsequent chronic diseases. Among females, HRs for 0, 7-20, 21-35 and .35 drinks?week -1 were 1.26 (95% CI 0.89-1.79), 1.01 (95% CI 0.88-1.17), 1.10 (95% CI 0.88-1.37) and 0.54 (95% CI 0.29-1.01), respectively. For the same moderate to high weekly alcohol amount, infrequent intake yielded higher pneumonia HRs than more regular intake in both sexes. Regular moderate alcohol intake is not associated with increased risk of hospitalisation for pneumonia. High weekly alcohol consumption in males and infrequent heavy drinking in both sexes may increase pneumonia risk.

Potential effect of PCV13 introduction on Emergency Department accesses for lower respiratory tract infections in elderly and at risk adults

“…12 A study conducted in Denmark between 1993 and 2008 reported rate of hospitalization for pneumonia lower than 4/1000 in >50 y adults. 13 In line with previous epidemiological data, the incidence of LRTI was strongly age related, with a linear increase in accesses, starting from 65-69 y age group. Between 65-69 y and 80-84 y classes, the grow ranged between 1 and 1.8 cases/1000 individuals in comparison with previous age group.…”

“…The reported hospitalization rates of LRTI and CAP in adults from different population varied between 1.1 and 2.8 per 1000 inhabitants-year 10,11 and between 2.6 and 4 per 1000 inhabitantsyear, 12,13 respectively. Even only considering age class, a large difference in incidence rates emerged.…”

Risk factors for community-acquired pneumonia in adults in Europe: a literature review

“…Most studies included adults of all ages. However, five studies considered only patients aged ≥65 years,12–16 two included patients aged 50–65 years,17 18 two included patients aged ≥45 years19 20 and single studies included patients aged ≥30 years,21 ≥40 years22 or 16–40 years 23. Six studies included only patients infected with HIV 24–29…”

“…The incidence of CAP was reported in 16 studies, from Denmark (n=2),17 18 France (n=3),24 26 29 Germany (n=1),36 Italy (n=2),27 37 Spain (n=5)16 25 38–40 and the UK (n=3) 19 41 42. Data are summarised in table 2, with more details available in online supplementary table S2.…”

Analysis of perioperative morbidity and mortality in shoulder arthroplasty patients with preexisting alcohol use disorders

“…12,22,34 This cohort is increasingly susceptible to sepsis and pneumonia and has a higher rate of mortality. 2,9,10,20 Further, it has also been shown that heavy drinkers have more postoperative complications after colon, prostate, and ankle surgery 39,42,43 ; specifically, this population experiences an increased risk of infection, 29 dysrhythmias and cardiac failure, 40,42 and prolonged bleeding time. 28 Given the high prevalence of alcohol abuse and its implications in early postoperative morbidity and mortality, 14,36,38 it is prudent to explore the effect of AUD in surgical candidates.…”