Alcohol Drinking and Bladder Cancer Risk From a Pooled Analysis of Ten Cohort Studies in Japan

Masaoka, Hiroyuki; Matsuo, Keitaro; Oze, Isao; Ito, Hidemi; Naito, Mariko; Wada, Keiko; Nagata, Chisato; Nakayama, Tomio; Kitamura, Yuri; Sadakane, Atsuko; Tamakoshi, Akiko; Tsuji, Ichiro; Sugawara, Yumi; Sawada, Norie; Mizoue, Tetsuya; Inoue, Manami; Tanaka, Keitaro; Tsugane, Shoichiro; Shimazu, Taichi

doi:10.2188/jea.je20190014

Cited by 2 publications

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References 28 publications

(27 reference statements)

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“…In this dose-response meta-analysis, we could not identify several eligible cohorts included in the above metaanalysis based on the electronic database retrieval because some cohort results were published in Japanese. Thus, we could not exam the association between alcohol consumption and bladder cancer risk in Japanese reported by Vartolomei et al ( 9) and Masaoka et al (8) and explore the dose-response relationship due to data limitation. Anyway, our results did not reveal any active association in specific regions, however, results in Europe and Japan should be validated and fleshed out in the further.…”

Section: Discussionmentioning

confidence: 92%

“…However, our meta-analysis of prospective cohort studies found no relationship between alcohol consumption and risk of bladder cancer in the USA and Europe while results of Europe showed significant heterogeneity. Additionally, Vartolomei and his colleagues revealed that heavy alcohol consumption increased significantly the risk of bladder cancer in the Japanese population ( 9 ) which conflicted with a meta-analysis of cohort studies conducted in Japan that null relationship was observed in both males and females ( 8 ). In this dose-response meta-analysis, we could not identify several eligible cohorts included in the above meta-analysis based on the electronic database retrieval because some cohort results were published in Japanese.…”

Section: Discussionmentioning

confidence: 98%

“…( 9 ) and Masaoka et al. ( 8 ) and explore the dose-response relationship due to data limitation. Anyway, our results did not reveal any active association in specific regions, however, results in Europe and Japan should be validated and fleshed out in the further.…”

Section: Discussionmentioning

confidence: 99%

“…However, the relationship between alcohol consumption and bladder cancer remains perplexing. A meta-analysis of ten cohort studies in Japan showed no evidence of an association between alcohol drinking and bladder cancer risk among men and women ( 8 ). But another meta-analysis of case-control and cohort studies suggested that heavy alcohol consumption increased significantly the risk of bladder cancer in men and the Japanese population without significant statistical heterogeneity ( 9 ).…”

Section: Introductionmentioning

confidence: 99%

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Association Between Alcohol Consumption and Risk of Bladder Cancer: A Dose-Response Meta-Analysis of Prospective Cohort Studies

Lao

et al. 2021

Front. Oncol.

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BackgroundControversial results of the association between alcohol consumption and risk of bladder cancer were reported by the previous meta-analyses.ObjectiveTo quantitatively investigate the association between alcohol consumption and risk of bladder cancer based on prospective cohort studies, and explore whether there is potential dose-response relation.MethodPubMed, EMBASE, the Cochrane Library databases, China Biology Medicine disc (CBM), and Chinese National Knowledge Infrastructure (CNKI) were searched for relevant studies. Categorical meta-analysis was performed for risk estimates of any alcohol consumers versus non-drinkers as well as different drinking degrees (light, moderate, and heavy) versus none. And two-stage generalized least-squares regression and restricted cubic spline, as well as fixed-effects dose-response models, were used for linear and nonlinear dose-response relation exploration.Results9 prospective cohort studies including 1,971,396 individuals were finally included. We did not observe a significant association between alcohol intake and the risk of bladder cancer in the entire population. Linear association was detected in those who consumed alcohol from liquor or spirits (P linear=0.02). One drink increment each day of alcohol could elevate the risk of bladder cancer by 9% (RR=1.09; 95%CI: 1.01-1.17). Alcohol was a risk factor of bladder cancer for male drinkers (RR=1.23; 95%CI: 1.13-1.35; I2=3.7%), while none linear or nonlinear relation was found.ConclusionNo significant association between alcohol consumption and bladder cancer risk was found in the entire population, but there was a linear dose-response relation in those who consume alcohol from liquor or spirits. Alcohol may elevate the risk of bladder cancer in males in a dose-independent way.Systematic Review Registrationhttps://www.crd.york.ac.uk/prospero/, PROSPERO (CRD42020216195).

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Section: Discussionmentioning

confidence: 92%

Section: Discussionmentioning

confidence: 98%