Alcohol Deprivation Effect Is Prolonged in the Alcohol Preferring (P) Rat After Repeated Deprivations

Rodd-Henricks, Zachary A.; McKinzie, David L.; Shaikh, Saame Raza; Murphy, James M.; McBride, William J.; Lumeng, Lawrence; Li, Ting‐Kai

doi:10.1097/00000374-200001000-00002

Cited by 56 publications

(84 citation statements)

References 32 publications

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“…In this study, it was demonstrated that the repeated-withdrawal protocol induced greater voluntary drinking of ethanol compared to that observed with continuous ethanol exposure. This change could be considered comparable to multiple cycles of alcohol deprivation enhancing drinking in the P-rat, as previously described (Rodd-Henricks et al, 2000, 2001. A particular key observation was the further increase in drinking following restraint stress application during the initial two withdrawals of the multiple-withdrawal protocol.…”

Section: Discussionsupporting

confidence: 62%

Stress Sensitization of Ethanol Withdrawal-Induced Reduction in Social Interaction: Inhibition by CRF-1 and Benzodiazepine Receptor Antagonists and a 5-HT1A-Receptor Agonist

Breese

Knapp

Overstreet

2003

Neuropsychopharmacol

108

195

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Repeated withdrawals from chronic ethanol sensitize the withdrawal-induced reduction in social interaction behaviors. This study determined whether stress might substitute for repeated withdrawals to facilitate withdrawal-induced anxiety-like behavior. When two 1-h periods of restraint stress were applied at 1-week intervals to rats fed control diet, social interaction was reduced upon withdrawal from a subsequent 5-day exposure to ethanol diet. Neither this ethanol exposure alone nor exposure to three restraint stresses alone altered this measure of anxiety. Further, the repeatedly stressed singly withdrawn rats continued to exhibit a reduction in social interaction 16 days later, upon withdrawal from re-exposure to 5 days of chronic ethanol, consistent with a persistent adaptation by the multiple-stress/withdrawal protocol. Weekly administration of corticosterone in place of stress induced no significant change in social interaction upon withdrawal from the single chronic ethanol exposure, indicative that corticoid release is not responsible for the stress-induced reduction in anxiety-like behavior during withdrawal. In the multiple-withdrawal protocol, stress applied during withdrawal from voluntary ethanol drinking by P-rats facilitated ethanol drinking sufficiently, to induce a withdrawal-induced reduction in social interaction. Administration of a CRF-1 receptor antagonist, a benzodiazepine receptor antagonist, or a 5-HT(1A) receptor agonist prior to each stress minimized sensitization of the withdrawal-induced reduction in anxiety-like behavior. Since these pharmacological consequences on the induction of anxiety-like behavior following the stress/withdrawal protocol are like those previously seen when these drug treatments were given prior to multiple withdrawals, evidence is provided that repeated stresses and multiple withdrawals sensitize the withdrawal reduction in social interaction by similar central adaptive mechanisms.

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Section: Discussionsupporting

confidence: 62%

Stress Sensitization of Ethanol Withdrawal-Induced Reduction in Social Interaction: Inhibition by CRF-1 and Benzodiazepine Receptor Antagonists and a 5-HT1A-Receptor Agonist

Breese

Knapp

Overstreet

2003

Neuropsychopharmacol

108

195

View full text Add to dashboard Cite

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“…Repeated cycles of deprivation have been shown to enhance and prolong ADE Rodd-Henricks et al 2000a) or to be necessary (Rodd-Henricks et al 2000b) for the manifestation of ADE. In the present study, we observed significant ADE in the non-stressed control group only after the second cycle of deprivation.…”

Section: Discussionmentioning

confidence: 99%

Influence of stressors on the rewarding effects of alcohol in Wistar rats: studies with alcohol deprivation and place conditioning

2004

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“…Studies conducted in rats have shown that once the positive reinforcing effects of ethanol are established in an operant self-administration paradigm, repeated chronic ethanol exposure and withdrawal experience resulted in increased responding for ethanol reinforcement (Brown et al 1998;Roberts et al 1996Roberts et al , 2000Valdez et al 2002). Similarly, after establishing stable ethanol intake in rats, repeated periods of deprivation resulted in increased ethanol consumption upon reaccess to the drug (an enhanced alcohol-deprivation effect) (Holter et al 1998;Rodd et al 2003;Rodd-Henricks et al 2000). Taken together, these reports suggest that repetitive experience with abstinence or ethanol withdrawal may influence future motivation to drink ethanol.…”

Section: Introductionmentioning

confidence: 99%

Effect of pattern and number of chronic ethanol exposures on subsequent voluntary ethanol intake in C57BL/6J mice

2005

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Rationale: We previously demonstrated that chronic ethanol exposure and withdrawal experience significantly increased subsequent voluntary ethanol intake in C57BL/6J mice. This study was conducted to examine chronic ethanol conditions that optimize this enhanced ethanol-drinking behavior. Objectives: The purpose of this study was to examine whether the pattern and/or number of chronic ethanol exposures influence subsequent ethanol intake. Methods: C57BL/6J mice were trained to drink ethanol (15% v/v) in a limited access situation (2 h/day) until stable intake was achieved. In experiment 1, mice received two cycles of chronic ethanol exposure delivered either in an intermittent [multiple withdrawal (MW)] or continuous [continuous exposure (CE)] pattern. One week of daily drinking sessions followed each exposure. In experiment 2, mice received either two or four cycles of chronic intermittent ethanol exposure (MW), each followed by a week of testing sessions. Three additional weeks of ethanol intake testing followed the last ethanol (or air) exposure. Results: Experiment 1: Only the MW group evidenced a significant increase in ethanol intake compared to controls after the first chronic ethanol exposure. Both MW and CE groups consumed more ethanol than controls after the second ethanol-exposure period. Experiment 2: Ethanol intake in MW mice compared to controls significantly increased after two or four cycles of chronic ethanol exposure/withdrawal, and this heightened ethanol intake lasted longer in mice that received four cycles of chronic intermittent ethanol exposure. Conclusions: Increased voluntary ethanol intake after chronic ethanol exposure and withdrawal experience may be accelerated by intermittent (as opposed to continuous) ethanol exposure, and the effect may last longer with increased number of such experiences.

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Alcohol Deprivation Effect Is Prolonged in the Alcohol Preferring (P) Rat After Repeated Deprivations

Cited by 56 publications

References 32 publications

Stress Sensitization of Ethanol Withdrawal-Induced Reduction in Social Interaction: Inhibition by CRF-1 and Benzodiazepine Receptor Antagonists and a 5-HT1A-Receptor Agonist

Stress Sensitization of Ethanol Withdrawal-Induced Reduction in Social Interaction: Inhibition by CRF-1 and Benzodiazepine Receptor Antagonists and a 5-HT1A-Receptor Agonist

Influence of stressors on the rewarding effects of alcohol in Wistar rats: studies with alcohol deprivation and place conditioning

Effect of pattern and number of chronic ethanol exposures on subsequent voluntary ethanol intake in C57BL/6J mice

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