Alcohol, dementia and cognitive decline in the elderly: a systematic review

Peters, Ruth; Peters, Jean; Warner, James; Beckett, Nigel; Bulpitt, Christopher J.

doi:10.1093/ageing/afn095

Cited by 325 publications

(261 citation statements)

References 29 publications

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“…Unhealthy behaviors, such as cigarette smoking and alcohol drinking, are associated with increased risk of AD and osteoporosis (Cheng 2009;Tysiewicz-Dudek et al 2008;Zhou et al 2011;Cataldo et al 2011;Deng et al 2010;Oddo et al 2005;Juan et al 2004;Peters et al 2008). In previous studies, the prevalence rate of cigarette smoking and alcohol consumption was 3-4 % and 1 %, respectively, in women aged over 16 years (Deng et al 2006;Anstey et al 2009).…”

Section: Discussionmentioning

confidence: 99%

Increased risk of dementia in patients with osteoporosis: a population-based retrospective cohort analysis

Chang

Chung

Lin

et al. 2013

AGE

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Osteoporosis is a common systemic skeletal disease that predominantly affects people older than 50 years and often co-occurs with dementia. The purpose of this study was to evaluate the risk of dementia in osteoporosis patients in Taiwan. Using data from Taiwan's National Health Insurance Research Database (NHIRD), we identified 23,941 patients with osteoporosis from 2000 to 2010 and 47,579 nonosteoporosis control patients, frequency-matched for age, sex, and index year, excluding patients with dementia at the baseline. We conducted univariate and multiple Cox proportional-hazards regression analyses to calculate the hazard ratios (HRs) and 95 % confidence intervals (CIs) of the association between osteoporosis and risk of dementia. After adjustment for potential risk factors, the osteoporosis patients exhibited 1.46-fold and 1.39-fold higher risk of dementia (95 % CI=1.37-1.56) and Alzheimer's disease (95 % CI=0.95-2.02), respectively, compared with the matched nonosteoporosis patients. We observed increased risk of dementia in both men and women with osteoporosis. The osteoporosis patients receiving bisphosphonate treatment or estrogen supplementation were associated with significantly lower risk of dementia compared with the osteoporosis patients who did not receive any treatment. Overall, our results suggest higher risks of dementia in osteoporosis patients than in nonosteoporosis patients. Osteoporosis could thus be considered an early risk factor for dementia. Future large- AGE (2014)

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Section: Discussionmentioning

confidence: 99%

Increased risk of dementia in patients with osteoporosis: a population-based retrospective cohort analysis

Chang

Chung

Lin

et al. 2013

AGE

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“…44 Finally, research on Alzheimer's disease and alcohol consumption has been suggestive of brain protection at lower levels of alcohol consumption but cognitive decline at higher levels. 45,46 Importantly, drinking alcohol even within guidelines can be detrimental to the optimal management of the relevant chronic condition(s). Prescription medications used to treat hypertension, hyperlipidemia, diabetes, and depression carry warning labels for alcohol consumption as the combination of alcohol and specific medication may result in symptoms such as dizziness, irregular heart beat, sudden drop in blood pressure, and fainting.…”

Section: Discussionmentioning

confidence: 99%

Drinking Patterns of Older Adults with Chronic Medical Conditions

et al. 2013

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BACKGROUND: Understanding alcohol consumption patterns of older adults with chronic illness is important given the aging baby boomer generation, the increase in prevalence of chronic conditions and associated medication use, and the potential consequences of excessive drinking in this population. OBJECTIVES: To estimate the prevalence of alcohol consumption patterns, including at-risk drinking, in older adults with at least one of seven common chronic conditions. DESIGN/METHODS: This descriptive study used the nationally representative 2005 Medicare Current Beneficiary Survey linked with Medicare claims. The sample included community-dwelling, fee-for-service beneficiaries 65 years and older with one or more of seven chronic conditions (Alzheimer's disease and other senile dementia, chronic obstructive pulmonary disease, depression, diabetes, heart failure, hypertension, and stroke; n=7,422). Based on selfreported alcohol consumption, individuals were categorized as nondrinkers, within-guidelines drinkers, or at-risk drinkers (exceeds guidelines). RESULTS: Overall, 30.9 % (CI 28.0-34.1 %) of older adults with at least one of seven chronic conditions reported alcohol consumption in a typical month in the past year, and 6.9 % (CI 6.0-7.8 %) reported at-risk drinking. Older adults with higher chronic disease burdens were less likely to report alcohol consumption and at-risk drinking. CONCLUSIONS: Nearly one-third of older adults with selected chronic illnesses report drinking alcohol and almost 7 % drink in excess of National Institute on Alcohol Abuse and Alcoholism (NIAAA) guidelines. It is important for physicians and patients to discuss alcohol consumption as a component of chronic illness management. In cases of at-risk drinking, providers have an opportunity to provide brief intervention or to offer referrals if needed.

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“…On the contrary, several studies assessing alcohol use among elderly have found that light to moderate alcohol consumption is associated with reduced risk for dementia [5,16,18,26]. A metaanalysis by Anstey et al [7] reported a 25-28 % estimated reduction in risk for any dementia associated with light to moderate alcohol intake compared to alcohol abstinence in older adults, but the causality was uncertain [11]. Using a relatively young sample (mean age of 58 years) at the time of the alcohol consumption assessment and long observation period, the present study does not support the hypothesis that infrequent alcohol consumption is associated with reduced risk of dementia compared to abstaining from alcohol.…”

Section: Discussionmentioning

confidence: 99%

“…With one exception [8], the approximately 25 studies that so far have specifically investigated the association between alcohol consumption and dementia risk [9] include only individuals aged 65 years or older at the time of the alcohol consumption assessment [3,[10][11][12][13][14][15][16][17][18]. Hence, the findings are only generalisable to alcohol consumption close in time to dementia onset.…”

Section: Introductionmentioning

confidence: 99%

Alcohol Consumption and Risk of Dementia Up to 27 Years Later in a Large, Population-Based Sample: The Hunt Study, Norway

2015

The Gerontologist

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The relationship between alcohol consumption and dementia risk is unclear. This investigation estimates the association between alcohol consumption reported in a population-based study in the mid-1980s and the risk for dementia up to 27 years later. The entire adult population in one Norwegian county was invited to the Nord-Trøn-delag Health Study during 1984-1986 (HUNT1): 88 % participated. The sample used in this study includes HUNT1 participants born between 1905 and 1946 who completed the questionnaire assessing alcohol consumption. A total of 40,435 individuals, of whom 1084 have developed dementia, are included in the analysis adjusted for age, sex, years of education, hypertension, obesity, smoking, and symptoms of depression. When adjusting for age and sex, and compared to reporting consumption of alcohol 1-4 times during the last 14 days (drinking infrequently), both abstaining from alcohol and reporting consumption of alcohol five or more times (drinking frequently) were statistically significantly associated with increased dementia risk with hazard ratios of 1.30 (95 % CI 1.05-1.61) and 1.45 (1.11-1.90), respectively. In the fully adjusted analysis, drinking alcohol frequently was still significantly associated with increased dementia risk with a hazard ratio of 1.40 (1.07-1.84). However, the association between dementia and abstaining from alcohol was no longer significant (1.15, 0.92-1.43). Equivalent results for Alzheimer's disease and vascular dementia indicated the same patterns of associations. When adjusting for other factors associated with dementia, frequent alcohol drinking, but not abstaining from alcohol, is associated with increased dementia risk compared to drinking alcohol infrequently.

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Alcohol, dementia and cognitive decline in the elderly: a systematic review

Abstract: because of the heterogeneity in the data these findings should be interpreted with caution. However, there is some evidence to suggest that limited alcohol intake in earlier adult life may be protective against incident dementia later.

Cited by 325 publications

References 29 publications

Increased risk of dementia in patients with osteoporosis: a population-based retrospective cohort analysis

Increased risk of dementia in patients with osteoporosis: a population-based retrospective cohort analysis

Drinking Patterns of Older Adults with Chronic Medical Conditions

Alcohol Consumption and Risk of Dementia Up to 27 Years Later in a Large, Population-Based Sample: The Hunt Study, Norway

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