Alcohol dehydrogenase (ADH) and aldehyde dehydrogenase (ALDH) in the cancer diseases

Prenatal alcohol exposure, blood alcohol concentrations and alcohol elimination rates for the mother, fetus and newborn

“…The placental ADH isozyme is analogous to class III ADH enzymes, which have a low affinity and a reduced metabolic rate for ethanol compared with other classes of ADH enzymes. 19 The alcohol oxidation rate of the placenta is estimated at 45.6 nmol h À1 g À1 of tissue, whereas the oxidation rate of the alcohol in the adult liver is increased over 3900 fold at 178 mmol h À1 per g of tissue. 20 Because of the reduced ethanol oxidation capacity of placental ADH, the placenta does not appear to have a significant role in the oxidative metabolism of ethanol.…”

DFT-Comparison of Anti-Cancer Effect of Ibuprofen Drug Anions and Breast Cancer Treatment by Ethanolic Solution of Nitrobenzaldehyde in Two Hours

“…Dealing with the ionization constant of ethanol molecule, it is not much different from water and it is necessary to take in our consideration the TD-DFT charge densities of the ethanol molecule, Table 8, as follows: It can be noticed from the previous values of ethanol charge densities that the hydrogen atom attached with the hydroxyl oxygen atom has the highest positive charge, 0.513135, Table 8 and the acidity of ethanol is nearly the same as that of water as indicated by their pKa being ranged between 15.7 -16. This means that the ratio between its anions and its molecular forms is very low even at blood pH = 7.4, therefore the loss of protons from ethanol molecule is weak possibility except by the aid of ADH enzyme in cancerous cells which performs much effort to do, as reported by Wojciech [11] . So, the cure of breast cancer tumor by Matthew Gdovin [12] is due to the electron transfer from the second and third excited states of para and ortho derivatives of nitrobenzaldehyde to the cationic guanine in the cancerous cells which may be enhanced by the proton production from ethyl alcohol and its main metabolite acetaldehyde by the enzymes ALDH whose activity is much lower than ADH enzymes [11], Figure 3.…”

“…The changes in activity of particular ADH isoenzymes in the sera of patients with different cancers, seemed to be caused by release of these isoenzymes from cancer cells, and may be useful for diagnostics of this cancer. The particular isoenzymes of ADH present in the serum may indicate to the cancer localization [11]. But if this assumption of losing the protons from nitrobenzaldehyde and ethyl alcohol to render the cancerous cells very acidic and commit suicide this means that the wine drink can cure cancer and of course this isn't the reality.…”

“…Hence, the ethanol molecules don't contribute in the electron transfer to the guanine cation in the cancerous cells in the uv region 325, 327 nm. However the alteration of ethanol to acetaldehyde due to ADH enzyme [11] has the heat content change being equal to 760.335 k cal mol −1 this means how much effort done by the ADH enzyme. Dealing with the ionization constant of ethanol molecule, it is not much different from water and it is necessary to take in our consideration the TD-DFT charge densities of the ethanol molecule, Table 8, as follows: It can be noticed from the previous values of ethanol charge densities that the hydrogen atom attached with the hydroxyl oxygen atom has the highest positive charge, 0.513135, Table 8 and the acidity of ethanol is nearly the same as that of water as indicated by their pKa being ranged between 15.7 -16.…”

“…liver, stomach, esophagus, colorectum). Moreover the activity of ADH is much higher than the activity of ALDH producing high acidity inside the cancerous degradation cells [11]. Efforts to destroy cancer cells without harming surrounding tissue, using beams of light to activate chemicals or particles in breast tumors have shown much promise.…”