Alcohol Dehydrogenase 3, Glutathione S-transferase M1 and T1 Polymorphisms, Alcohol Consumption and Hepatocellular Carcinoma (Italy)

Covolo, Loredana; Gelatti, Umberto; Talamini, Renato; Garte, Seymour; Trevisi, Paola; Franceschi, Silvia; Franceschini, Michela; Barbone, Fabio; Tagger, A.; Ribero, M.L.; Parrinello, Giovanni; Donadon, Valter; Donato, Francesco

doi:10.1007/s10552-005-2302-2

Cited by 27 publications

(17 citation statements)

References 35 publications

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“…Glutathione S‐transferases are cytosolic proteins which facilitate the conjugation of several electrophilic and xenobiotic compounds with glutathione. They participate in cellular detoxification, the heat shock response, and neutralization of reactive oxygen species 43‐45. Our data regarding the effects of IPC on GST are robust because they are group‐specific for IPC, PCR experiments substantiate the results from microarrays, and increased transcript expression is translated into increased protein levels.…”

Section: Discussionsupporting

confidence: 68%

Global gene expression profiles of ischemic preconditioning in deceased donor liver transplantation

Raza

Dikdan²,

Desai³

et al. 2010

Liver Transpl

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Section: Discussionsupporting

confidence: 68%

Global gene expression profiles of ischemic preconditioning in deceased donor liver transplantation

Raza

Dikdan²,

Desai³

et al. 2010

Liver Transpl

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“…However, a number of such findings are reported for the mu class, which appears to be differentially expressed between the AA and ANA animals as well. Human GSTM1 null mutation has been associated with an increased risk of alcoholism (24,25) but not with severe alcohol withdrawal syndrome (48). This appears to be opposite to the findings in the ethanol-preferring animal, where the mu class seems to be up-regulated (see below), and might point to important differences between the ethanol-preferring phenotype in animals and alcoholism as a human psychopathological state.…”

Section: Discussionmentioning

confidence: 85%

“…Lipid peroxidation products, such as 4-HNE, can directly modulate the binding and functional properties of dopamine D1/D5 receptors, as well as effector proteins within their signaling pathway (23). Furthermore, human allelic variants of the GSTM1 gene (glutathione S-transferase mu1) have been associated with increased alcoholism and liver disease (24,25).…”

mentioning

confidence: 99%

Glutathione‐S‐transferase expression in the brain: possible role in ethanol preference and longevity

Björk

Saarikoski²,

Arlinde³

et al. 2006

FASEB j.

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Identification of genes that are differentially expressed in rats bidirectionally selected for alcohol preference might reveal biological mechanisms underlying alcoholism or related phenotypes. Microarray analysis from medial prefrontal cortex (mPFC), a key brain region for drug reward, indicated increased expression of glutathione-S-transferases of the alpha (Gsta4) and mu (Gstm1-5) classes in ethanol-preferring AA rats compared with nonpreferring ANA rats. Real-time RT polymerase chain reaction (RT-PCR) analysis demonstrated approximately 2-fold higher Gsta4 transcript levels in several brain regions of ethanol-naive AA compared with ANA rats. Differences in mRNA levels were accompanied by differential levels of GSTA4 protein. We identified a novel haplotype variant in the rat Gsta4 gene, defined here as var3. Allele frequencies of var3 were markedly different between AA and ANA rats, 52% and 100%, respectively. Gsta4 expression was strongly correlated with the gene dose of var3, with approximately 60% of the variance in expression accounted for by genotype at this locus. The contribution of glutathione S-transferase expression to the ethanol-preferring phenotype is presently unclear. It could, however, underlie observed differences in life span between AA and ANA lines, prompting a utility of this animal model in aging research.

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“…In rodents, transcript and proteins levels the GST-α4 isoform were lower in the amygdala, but higher in the hippocampus of alcohol-preferring compared with non-preferring rats [86,87], suggesting a possible role for GST in regulating voluntary alcohol consumption. Indeed, null mutations in GSTμ1 are associated with an increased risk for AUDs [88]. Curiously, the expression level of GSTμ class was increased in the medial prefrontal cortex of alcohol-preferring rats [86].…”

Section: Drugs Of Abuse and Oxidative/nitrosative Stressmentioning

confidence: 99%

Glutathione and redox signaling in substance abuse

Uys

Mulholland

Townsend

2014

Biomedicine & Pharmacotherapy

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Throughout the last couple decades, the cause and consequences of substance abuse has expanded to identify the underlying neurobiological signaling mechanisms associated with addictive behavior. Chronic use of drugs, such as cocaine, methamphetamine and alcohol leads to the formation of oxidative or nitrosative stress (ROS/RNS) and changes in glutathione and redox homeostasis. Of importance, redox-sensitive post-translational modifications on cysteine residues, such as S-glutathionylation and S-nitrosylation could impact on the structure and function of addiction related signaling proteins. In this commentary, we evaluate the role of glutathione and redox signaling in cocaine-, methamphetamine- and alcohol addiction and conclude by discussing the possibility of targeting redox pathways for the therapeutic intervention of these substance abuse disorders.

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Alcohol Dehydrogenase 3, Glutathione S-transferase M1 and T1 Polymorphisms, Alcohol Consumption and Hepatocellular Carcinoma (Italy)

Abstract: ADH3(1-1) and GSTT1 null genotypes did not modify the risk of HCC due to alcohol intake whereas an influence of GSTM1 null genotype for high ethanol consumption was suggested.

Cited by 27 publications

References 35 publications

Global gene expression profiles of ischemic preconditioning in deceased donor liver transplantation

Global gene expression profiles of ischemic preconditioning in deceased donor liver transplantation

Glutathione‐S‐transferase expression in the brain: possible role in ethanol preference and longevity

Glutathione and redox signaling in substance abuse

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