Alcohol consumption patterns and the risk of sarcopenia: a population-based cross-sectional study among chinese women and men from Henan province

Zhai, Junya; Ma, Baihui; Qin, Jing; Lyu, Quanjun; Khatun, Pipasha; Liang, Rui; Ma, Cong; Guo, Lijun; Kong, Yongxia

doi:10.1186/s12889-022-14275-6

Cited by 14 publications

(11 citation statements)

References 35 publications

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“…Secondly, in the present study, fast food, alcoholic beverages, sugar, preserved fruits, beverages and seasonings had lower NRF9.2 scores (Table 2). Our research team showed that heavy alcohol consumption and frequent drinking are important risk factors for low muscle mass and muscle strength in Chinese men [32] . Thirdly, the NRF9.2 index composed of nine bene cial nutrients (protein, ber, vitamin A, vitamin C, vitamin E, calcium, iron, potassium, magnesium) and two limited nutrients (saturated fat, sodium).…”

Section: Discussionmentioning

confidence: 92%

Association of dietary nutrient density with the risk of sarcopenia and its components in Chinese adults from Henan province

Zhai,

Ma,

Zhang

et al. 2024

Preprint

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Objectives The Nutrient-Rich Foods (NRF) Index is one of the critical elements of diet quality based on nutrient density. NRF9.2 is a validated tool to assess dietary quality among Chinese adults from Henan province. Previous studies showed that lifestyle interventions may prevent or delay sarcopenia. Nutrient density has not yet been evaluated concerning muscle health. Therefore, the association between the NRF9.2 index and the risk of sarcopenia and its elements was explored based on a cross-sectional study of general Chinese adults from Henan Province. Methods A total of 631 individuals aged 18–75 years recruited in three communities in Henan, China. The criteria for defining sarcopenia were updated by the Asian Working Group for Sarcopenia (AWGS) in 2019. The NRF9.2 index was calculated based on nine beneficial nutrients and two nutrients to limit, using the algorithm based on sums and 100 kcal. Binary logistic regression analysis was used to estimate the risk of sarcopenia and its elements associated with nutrient density. Results A total of 353 non-repetitive foods consumed by subjects were scored using the NRF9.2 algorithms. Vegetables, bacteria and algae, dried beans, products, fruits, and fish had higher NRF9.2 scores, while fast food, alcoholic beverages, sugar, preserved fruits, beverages, and seasonings had lower NRF9.2 scores. After multiple adjustments, participants with the highest NRF9.2 score (the fourth quartile) had a 55% lower risk of low grip strength than those in the lowest group (the first quartile) [OR (95% CI) = 0.45 (0.21,0.93)]. The NRF9.2 score was not related to the risk of sarcopenia, ASMI, or gait speed. Conclusion After multiple adjustments, participants with high nutrient density had a low risk of low grip strength than those with low nutrient density. These results revealed that the nutrient density model can help individuals make healthy food choices and build a healthy diet to decrease the risk of low grip strength.

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Section: Discussionmentioning

confidence: 92%

Association of dietary nutrient density with the risk of sarcopenia and its components in Chinese adults from Henan province

Zhai,

Ma,

Zhang

et al. 2024

Preprint

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“…113 Similarly, in a cross-sectional study among people living in China, men who consumed more than 25 g of alcohol per day had increased risk of low muscle mass and grip strength. 114 In animal studies, female mice consuming 20% alcohol in water for 40 weeks had decreased grip strength and decreased lean muscle mass, without major neuromuscular junction changes, suggesting that muscle weakness is potentially driven by muscle atrophy. 115 In other studies, fatigability and alterations in twitch and tetanic tension were seen with chronic alcohol intake.…”

Section: Results Of the Reviewed Studiesmentioning

confidence: 99%

Alcohol and Skeletal Muscle in Health and Disease

Simon

2023

ARCR

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PURPOSE Alcohol-related myopathy is one of the earliest alcohol-associated pathological tissue changes that is progressively exacerbated by cumulative long-term alcohol misuse. Acute and chronic alcohol use leads to changes in skeletal muscle mass and function. As discussed in this evidence-based review, alcohol-mediated mechanisms are multifactorial with effects on anabolic and catabolic signaling, mitochondrial bioenergetics, extracellular matrix remodeling, and epigenomic alterations. However, systematic studies are limited, especially regarding the acute effects of alcohol on skeletal muscle. SEARCH METHODS This review focuses on peer-reviewed manuscripts published between January 2012 and November 2022 using the search terms “alcohol” or “ethanol” and “skeletal muscle” in MEDLINE, PubMed, and Web of Science using EndNote reference management software. SEARCH RESULTS Eligible manuscripts included full-length research papers that discussed acute and chronic effects of alcohol on skeletal muscle mass and function in both clinical and preclinical studies. The review also includes alcohol-mediated skeletal muscle effects in the context of comorbidities. The three databases together yielded 708 manuscripts. Of these, the authors excluded from this review 548 papers that did not have “alcohol” or “muscle” in the title and 64 papers that were duplicates or did not discuss skeletal muscle. Thus, of all the manuscripts considered for this review, 96 are included and 612 are excluded. Additionally, relevant papers published earlier than 2012 are included to provide context to the review. DISCUSSION AND CONCLUSIONS Both acute and chronic alcohol use decrease protein synthesis and increase protein degradation. Alcohol also impairs mitochondrial function and extracellular matrix remodeling. However, there is a gap in the literature on the known alcohol-mediated mechanisms, including senescence, role of immune activation, and interorgan communication, on the development of alcohol-related myopathy. With increased life expectancy, changing alcohol use patterns, and increasing frequency of alcohol use among females, current observational studies are needed on the prevalence of alcohol-related myopathy. Additionally, the compounding effects of acute and chronic alcohol use on skeletal muscle with aging or exercise, in response to injury or disuse, and in the context of comorbidities including diabetes and human immunodeficiency virus (HIV), call for further investigation. Though evidence suggests that abstinence or reducing alcohol use can improve muscle mass and function, they are not restored to normal levels. Hence, understanding the pathophysiological mechanisms can help in the design of therapeutic strategies to improve skeletal muscle health.

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“…Fourth, GFR decline might be underestimated in participants with high alcohol consumption in this meta-analysis. Because high alcohol consumption is associated with low muscle mass [ 74 , 75 ] and serum creatinine level is heavily dependent on muscle mass [ 76 ], serum creatinine-based eGFR is likely to increase during the observational period among the participants with high alcohol consumption. Thus, a deleterious effect of high alcohol consumption on GFR might be blunted in the cohort studies included in this meta-analysis, in which GFR was estimated using serum creatinine-based equation.…”

Section: Discussionmentioning

confidence: 99%

A Dose-Dependent Association between Alcohol Consumption and Incidence of Proteinuria and Low Glomerular Filtration Rate: A Systematic Review and Meta-Analysis of Cohort Studies

Yamamoto

Otsuki

et al. 2023

Nutrients

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Previous cohort studies have reported conflicting associations between alcohol consumption and chronic kidney disease, characterized by proteinuria and low glomerular filtration rate (GFR). This systematic review, which included 14,634,940 participants from 11 cohort studies, assessed a dose-dependent association of alcohol consumption and incidence of proteinuria and low estimated GFR (eGFR) of <60 mL/min/1.73 m2. Compared with non-drinkers, the incidence of proteinuria was lower in drinkers with alcohol consumption of ≤12.0 g/day (relative risk 0.87 [95% confidence interval 0.83, 0.92]), but higher in drinkers with alcohol consumption of 36.1–60.0 g/day (1.09 [1.03, 1.15]), suggesting a J-shaped association between alcohol consumption and the incidence of proteinuria. Incidence of low eGFR was lower in drinkers with alcohol consumption of ≤12.0 and 12.1–36.0 than in non-drinkers (≤12.0, 12.1–36.0, and 36.1–60.0 g/day: 0.93 [0.90, 0.95], 0.82 [0.78, 0.86], and 0.89 [0.77, 1.03], respectively), suggesting that drinkers were at lower risk of low eGFR. In conclusion, compared with non-drinkers, mild drinkers were at lower risk of proteinuria and low eGFR, whereas heavy drinkers had a higher risk of proteinuria but a lower risk of low eGFR. The clinical impact of high alcohol consumption should be assessed in well-designed studies.

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Alcohol consumption patterns and the risk of sarcopenia: a population-based cross-sectional study among chinese women and men from Henan province

Cited by 14 publications

References 35 publications

Association of dietary nutrient density with the risk of sarcopenia and its components in Chinese adults from Henan province

Association of dietary nutrient density with the risk of sarcopenia and its components in Chinese adults from Henan province

Alcohol and Skeletal Muscle in Health and Disease

A Dose-Dependent Association between Alcohol Consumption and Incidence of Proteinuria and Low Glomerular Filtration Rate: A Systematic Review and Meta-Analysis of Cohort Studies

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