Alcohol consumption is associated with progression of hepatic fibrosis in non-alcoholic fatty liver disease

Ekstedt, Mattias; Franzén, Lennart; Holmqvist, Marika; Bendtsen, Preben; Mathiesen, Ulrik; Bodemar, Göran; Kechagias, Stergios

doi:10.1080/00365520802555991

Cited by 184 publications

(167 citation statements)

References 32 publications

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“…Recently, the co-existence of NAFLD and alcoholic liver disease (ALD) has been increasingly recognised in clinical settings. The presence of NAFLD in alcoholic patients has been linked with progression of ALD [97] , while some have shown that moderate alcohol consumption is associated with fibrosis progression in NAFLD [98] . Interestingly, in contrast, several studies have shown a beneficial effect of moderate alcohol intake.…”

Section: Histological Findings Of Nafld/ Nash In Concurrence With Othmentioning

confidence: 99%

Histopathology of Non-Alcoholic Fatty Liver Disease

Brunt

2009

Clinics in Liver Disease

114

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Histological analysis of liver biopsies remains a standard against which other methods of assessment for the presence and amount of hepatic injury due to nonalcoholic fatty liver disease (NAFLD) are measured. Histological evaluation remains the sole method of distinguishing steatosis from advanced forms of NAFLD, i.e. nonalcoholic steatohepatitis (NASH) and fibrosis. Included in the lesions of NAFLD are steatosis, lobular and portal inflammation, hepatocyte injury in the forms of ballooning and apoptosis, and fibrosis. However, patterns of these lesions are as distinguishing as the lesions themselves. Liver injury in adults and children due to NAFLD may have different histological patterns. In this review, the rationale for liver biopsy, as well as the histopathological lesions, the microscopically observable patterns of injury, and the differential diagnoses of NAFLD and NASH are discussed.

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Section: Histological Findings Of Nafld/ Nash In Concurrence With Othmentioning

confidence: 99%

Histopathology of Non-Alcoholic Fatty Liver Disease

Brunt

2009

Clinics in Liver Disease

114

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“…A more recent study from Sweden investigated whether low alcohol intake, consistent with the diagnosis of NAFLD, is associated with fi brosis progression in 71 subjects with biopsy-proven NAFLD [ 49 ]. By multivariate binary logistic regression analysis, heavy episodic drinking ( p < 0.001) and insulin resistance ( p < 0.01) were independently associated with signifi cant fi brosis progression.…”

Section: Non-alcoholic Fatty Liver Diseasementioning

confidence: 98%

Alcoholic Cirrhosis and Hepatocellular Carcinoma

Stickel¹

2014

Biological Basis of Alcohol-Induced Cancer

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Hepatocellular carcinoma shows a rising incidence worldwide, and the largest burden of disease in Western countries derives from patients with alcoholic liver disease (ALD) and cirrhosis, the latter being the premier premalignant factor for HCC. The present chapter addresses key issues including the epidemiology of alcohol-associated HCC, and its link to other coexisting non-alcoholic liver diseases, and additional host and environmental risk factors including the underlying genetics. Also discussed are molecular mechanisms of alcohol-associated liver cancer evolution involving the mediators of alcohol toxicity and carcinogenicity, acetaldehyde and reactive oxygen species, as well as the recently described mutagenic adducts which these mediators form with DNA. Specifically, interference of alcohol with retinoids and cofactors of transmethylation processes are outlined. Information presented in this chapter illustrates that the development of HCC in the context of ALD is multifaceted and suggests several molecular targets for prevention and markers for the screening of risk groups.

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“…НАЖБП может сочетаться с алкогольным поражени-ем печени у пациентов с метаболическим синдромом при приеме алкоголя более 60 г/сут для мужчин и более 40 г/сут для женщин, что может привести к более агрессив-ному течению заболевания [9].…”

Section: эпидемиологияunclassified

Nonalcoholic fatty liver disease: cause or consequence of insulin resistance?

Mishina¹,

Mayorov²,

Богомолов³

et al. 2017

Diabetes mellitus

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Более 30 лет назад Ludwig J. (1980) описал заболева-ние, сходное с алкогольным стеатогепатитом, у пациентов с сахарным диабетом (СД), не употребляющих алкоголь, и назвал данное заболевание неалкогольным стеатогепа-титом (НАСГ) [1]. Неалкогольная жировая болезнь печени (НАЖБП) является самым распространенным хроническим заболеванием печени и приняла масштаб эпидемии, так же как ожирение и СД 2 типа (СД2) [2]. НАЖБП включает в себя спектр заболеваний от жирового гепатоза без признаков воспаления до НАСГ, цирроза печени и гепатоцеллюляр-ной карциномы [3]. ЭПИДЕМИОЛОГИЯОписанная распространенность НАЖБП широ-ко варьирует в зависимости от изучаемой популяции и от используе мого метода диагностики. Распространен-ность гистологически подтвержденной НАЖБП состав-ляет от 20 до 51%, однако, по данным ультразвукового метода исследования, НАЖБП встречается реже, от 17 до 46% [4] Неалкогольная жировая болезнь печени (НАЖБП) и сахарный диабет 2 типа (СД2) -патологические состояния, ассоцииро-ванные друг с другом и достигающие размеров эпидемии. Одним из наиболее значимых факторов риска развития как СД2, так и НАЖБП является ожирение, которое усиливает имеющуюся инсулинорезистентность (ИР). Последняя является ос-новным патогенетическим звеном СД2 и НАЖБП, связывая эти два патологических состояния. В настоящее время повышен интерес к поиску неинвазивных методик исследования; для оценки фиброза и определения показаний для биопсии печени неинвазивным методом используется Шкала оценки стадии фиброза при НАЖБП (NAFLD fibrosis score), расширенная панель фиброза печени (ELF) и транзиентная эластография. Однако золотым стандартом диагностики остается биопсия печени. Ввиду того, что у пациентов с СД чаще выявляется НАЖБП, чем в общей популяции, а также учитывая, что наличие СД явля-ется фактором риска прогрессии НАЖБП, данная когорта пациентов должна находиться под более тщательным контролем клиницистов. Данная обзорная работа посвящена поиску причинно-следственных связей таких коморбидных заболеваний, как НАЖБП и различные нарушения углеводного обмена, а также приоритетным направлениям диагностики НАЖБП.КЛЮЧЕВЫЕ СЛОВА: инсулинорезистентность; сахарный диабет; неалкогольная жировая болезнь печени; неалкогольный стеатогепатит; ожирение NONALCOHOLIC FATTY LIVER DISEASE: CAUSE OR CONSEQUENCE OF INSULIN RESISTANCE?© Ekaterina E. Nonalcoholic fatty liver disease (NAFLD) and type 2 diabetes mellitus (T2DM) are pathological conditions that are co-occurring, and have been reaching epidemic proportions. One of the most significant risk factors for the development of both T2DM and NAFLD is obesity, which increases existing insulin resistance (IR). IR thought to be one of the main pathogenic causes linking T2DM and NAFLD. In recent years, there has been increased interest in obtaining non-invasive methods for assessing fibrosis and determining indications for liver biopsy, such as the NAFLD fibrosis score, extended liver fibrosis panel, and transient elastography. However, liver biopsy remains the gold standard for diagnosing NAFLD. Given that pa...

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Alcohol consumption is associated with progression of hepatic fibrosis in non-alcoholic fatty liver disease

Abstract: Moderate alcohol consumption, consistent with the diagnosis of NAFLD to be set, is associated with fibrosis progression in NAFLD. These patients should be advised to refrain from heavy episodic drinking.

Cited by 184 publications

References 32 publications

Histopathology of Non-Alcoholic Fatty Liver Disease

Histopathology of Non-Alcoholic Fatty Liver Disease

Alcoholic Cirrhosis and Hepatocellular Carcinoma

Nonalcoholic fatty liver disease: cause or consequence of insulin resistance?

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