Alcohol Consumption Is Associated with Decreased Insulin Resistance Independent of Body Mass Index in Japanese Community-Dwelling Men

Kawamoto, Ryuichi; Kohara, Katsuhiko; Tabara, Yasuharu; Miki, Tetsuro; Ohtsuka, Nobuyuki; Kusunoki, Tomo; Abe, Masanori

doi:10.1620/tjem.218.331

Cited by 23 publications

(18 citation statements)

References 35 publications

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“…In the decade that has passed since the earlier work described above, the beneficial effects of moderate alcohol consumption upon health, especially in reducing the risk for CHD and IH, as well as the major mechanisms responsible for these benefits, have been repeatedly confirmed (44)(45)(46)(47)(48)(49)(50). Interest in the biological actions and potential health benefits of resveratrol have accelerated, and reports have claimed to reproduce several of these in whole animal or human investigations.…”

Section: Discussionmentioning

confidence: 95%

Wine and Health: A Paradigm for Alcohol and Antioxidants

Goldberg¹,

Soleas²

2011

Journal of Medical Biochemistry

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Kratak sadr`aj: Mnoga epidemiolo{ka istra`ivanja su poka zala da umereno konzumiranje alkohola produ`ava o~e -kivani `ivotni vek tako {to smanjuje rizik od izvesnih bolesti. Pomenuti smanjeni rizik najva`niji je kod koronarne sr~ane bolesti i ishemijskog mo`danog udara, koje izaziva ate rosklerotska vaskularna bolest. Postoje tvrdnje da takvi efekti zavise od vrste pi}a, kao i da crno vino ima najmo } nije dejstvo. Ovaj pregled ispita}e relativni doprinos etanola i polifenolskih antioksidanata iz crnog vina, razmatraju}i njihov potencijal da inhibiraju aterogenezu i njene meha nizme. Postoji valjani dokazi, kako in vitro tako i in vivo, da etanol pove}ava produkciju i cirkuli{u}e nivoe HDL-holeste rola i smanjuje formiranje ugru{aka tako {to blokira aktiv nost trombina i inhibiciju fibrinolize. Na taj na~in spreava migraciju glatkih mi{i}nih }elija u intimalni sloj arterija i sni`ava incidencu dijabetes melitusa tipa 2, kao va`nog faktora rizika za aterosklerotsku bolest. Crno vino pored etanola sadr`i mnoge polifenolske antioksidante tako|e prisutne u vo}u i povr}u (npr. katehin i kvercetin), kao i rezveratrol koji se gotovo isklju~ivo nalazi u gro`|u i crnom vinu. U in vitro eksperimentima pokazano je da ti polifenoli, naro~ito rezveratrol, iskazuju mo}na svojstva koja omogu}avaju spre~avanje ateroskleroze. Pored toga {to smanjuju formiranje ugru{aka, oni ubla`avaju inflamatorne reakcije regulisanjem produkcije eikozanoida i citokina, spre~avaju oksidaciju LDL, smanjuju ekspresiju molekula }elijske adhezije i pove}avaju produkciju NO. Me|utim, istra`ivanja nà ivotinjama i ljudima dala su protivre~ne rezultate. Taj paradoks mogu objasniti studije koje pokazuju da te polifenole, uzete oralno, mukoza tankog creva brzo konjuguje sa glukuronidom i sulfatom pre apsorpcije, posle ~ega bubrezi Summary: Moderate alcohol consumption has been shown in many epidemiological investigations to prolong overall life expectancy by reducing the risk of certain diseases. Those that account most for this reduction are coronary heart disease and ischemic stroke, both of which are caused by atherosclerotic vascular disease. It has been claimed that these effects are beverage-specific, with red wine being the most potent. This review examines the relative contributions of ethanol and the polyphenolic antioxidants of red wine by considering their potential to inhibit atherogenesis and the mechanisms involved. There is good evidence, both in vitro and in vivo, that ethanol increases production and circulating levels of HDL-Cholesterol, and reduces clot formation by blocking thrombin activity as well as by inhibition of fibrinolysis. It also prevents migration of smooth-muscle cells to the intimal layer of arteries and reduces the incidence of Type II Diabetes Mellitus, a major risk factor for atherosclerotic disease. Red wine, in addition to ethanol, contains many polyphenolic antioxidants that are also present in fruit and vegetables (such as catechin and quercetin), as well as resveratrol that is almost restricted to grapes and red w...

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Section: Discussionmentioning

confidence: 95%

Wine and Health: A Paradigm for Alcohol and Antioxidants

Goldberg¹,

Soleas²

2011

Journal of Medical Biochemistry

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“…In our study, hemoglobin per se was associated with other comorbidities, such as increased BMI, alcohol consumption, smoking status, blood pressure, TG, uric acid, and HOMA-IR, and decreased HDL-C. All these risk factors relate to insu- Table 4. a P 0.05 and A P 0.01, hemoglobin-1 vs hemoglobin-4; b P 0.05 and B P 0.01, hemoglobin-1 vs hemoglobin-3; c P 0.05, hemoglobin-1 vs hemoglobin-2; d P 0.05, hemoglobin-2 vs hemoglobin-4 lin resistance 33) and result in endothelial dysfunction 34) . Furthermore, in our study, the hemoglobin status was inversely associated with decreased serum HMW adiponectin levels, especially in participants with BMI 23.0 kg/m 2 , alcohol drinkers, and HOMA-IR 1.6, in which insulin resistance was lower 33) .…”

Section: Discussionmentioning

confidence: 99%

“…a P 0.05 and A P 0.01, hemoglobin-1 vs hemoglobin-4; b P 0.05 and B P 0.01, hemoglobin-1 vs hemoglobin-3; c P 0.05, hemoglobin-1 vs hemoglobin-2; d P 0.05, hemoglobin-2 vs hemoglobin-4 lin resistance 33) and result in endothelial dysfunction 34) . Furthermore, in our study, the hemoglobin status was inversely associated with decreased serum HMW adiponectin levels, especially in participants with BMI 23.0 kg/m 2 , alcohol drinkers, and HOMA-IR 1.6, in which insulin resistance was lower 33) . The effect of hemoglobin on serum HMW adiponectin levels may occur easily in these groups.…”

Section: Discussionmentioning

confidence: 99%

Hemoglobin is Associated with Serum High Molecular Weight Adiponectin in Japanese Community-Dwelling Persons

Kawamoto

Tabara

Kohara

et al. 2011

JAT

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“…Moderate alcohol consumption may thus be protective against insulin resistance and the development of type 2 diabetes, whereas high intake seems to increase the risk. Alcohol intake does not show simple linear relationships with insulin resistance, but rather, a U-shaped curve [53,56].…”

Section: Alcohol Consumption With Insulin Resistancementioning

confidence: 92%

“…HDL-c, high-density lipoprotein-cholesterol; RAS, renin-angiotensin system; UA, uric acid; XO, xanthine oxidase. been associated with a lower risk of type 2 diabetes [51,52], and is associated with decreased insulin resistance independent of BMI [53]. By contrast, chronic alcohol-related liver disease was found to be associated with increased expression of insulin [54], and there is evidence that chronic high-level ethanol consumption inhibits DNA synthesis and regenerative and reparative capacities of the liver, which may be due to inhibition of insulin signaling [55].…”

Section: Alcohol Consumption With Insulin Resistancementioning

confidence: 99%