Alcohol consumption increases locomotion in an open field and induces Fos-immunoreactivity in reward and approach/withdrawal-related neurocircuitries

Wscieklica, Tatiana; Viana, Milena de Barros; Sueur-Maluf, Luciana Le; Pouza, Kathlein Cristiny Peres; Spadari, Regina Célia; Céspedes, Isabel Cristina

doi:10.1016/j.alcohol.2015.11.005

Cited by 18 publications

(4 citation statements)

References 82 publications

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“…; Wscieklica et al . ). In rodents, adolescence is commonly divided into three time periods: early adolescence (21–34 days postnatal), middle adolescence (34–46 days postnatal) and late adolescence (46–59 days postnatal; Spear, ; Laviola et al .…”

Section: Discussionmentioning

confidence: 97%

“…However, phenotypic plasticity implies a cost for early adaptation that can be paid during development later in life (West-Eberhard, 2005). In this context, patterns of locomotor activity were evaluated in pups at different ages (23, 45 and 60 days old) in the 'open field' , according to previous studies (Barros et al 2006;Aragão et al 2011;Hu et al 2015;Wscieklica et al 2016). In rodents, adolescence is commonly divided into three time periods: early adolescence (21-34 days postnatal), middle adolescence (34-46 days postnatal) and late adolescence (46-59 days postnatal; Spear, 2000;Laviola et al 2003).…”

Section: Discussionmentioning

confidence: 99%

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Maternal voluntary physical activity attenuates delayed neurodevelopment in malnourished rats

Fragoso

Lira

Chagas

et al. 2017

Experimental Physiology

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What is the central question of this study? In the present study, a reproducible model of maternal voluntary physical activity was developed to evaluate the adaptive response of physical activity by attenuating the effects of maternal undernutrition on physical features, reflex ontogeny and growth trajectory of offspring during development. What is the main finding and its importance? Maternal physical activity may induce neuronal maturation of sensorimotor connections impacting on the patterns of locomotor activity in malnourished offspring. Thus, physical activity should be considered as a therapeutic means of countering the effects of maternal undernutrition, by providing a useful strategy for enhancing the neuronal activity of children born to mothers who experience a restricted diet during pregnancy. This study evaluated the effects of maternal voluntary physical activity during pregnancy and lactation on somatic growth (SG), reflex ontogeny (RO) and locomotor activity (LA) of rats whose mothers were protein restricted. Virgin female Wistar rats were divided into the following six groups: control, normal protein (C-NP, n = 4); control, low protein (C-LP, n = 4); inactive, normal protein (I-NP, n = 8); inactive, low protein (I-LP, n = 7); very active, normal protein (VA-NP, n = 8); and very active, low protein (VA-LP, n = 6). Voluntary physical activity was recorded daily in dams. The LP groups were fed an 8% casein diet, whereas control groups were fed a 17% casein diet during pregnancy and lactation. Offspring were evaluated in terms of SG (body weight and length, latero-lateral skull axis and anteroposterior head axis) and RO (palmar grasp, righting, free-fall righting, negative geotaxis, cliff avoidance, auditory startle response and vibrissa placing). The LA was evaluated at 23, 45 and 60 days old in the open field. Voluntary physical activity was reduced during pregnancy and lactation independent of the maternal diet. Pups from LP dams showed delayed SG, reflex maturation and patterns of LA when compared with control pups. The C-LP and I-LP pups showed a delayed SG, RO and LA. Pups from VA-LP mothers showed no delay in SG and RO and presented a faster development of patterns of LA. Maternal voluntary physical activity attenuated the effects of LP diet on indicators of neurodevelopment and patterns of LA of offspring.

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Section: Discussionmentioning

confidence: 97%

Section: Discussionmentioning

confidence: 99%

Maternal voluntary physical activity attenuates delayed neurodevelopment in malnourished rats

Fragoso

Lira

Chagas

et al. 2017

Experimental Physiology

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“…Furthermore, CaMKII autophosphorylation-deficient mice demonstrate enhanced negative reinforcing actions of ethanol [25], suggesting a role for CaMKII autophosphorylation in the negative affective state observed in chronic intermittent ethanol vapor exposure (CIE) rats. In support of this hypothesis, recent studies indicate that neural activity in the ventral striatum is critical for the neurochemical effects of ethanol, which may contribute to further excessive ethanol consumption and dependence [26,27]. More notable is that reduced activity of CaMKII at its autophosphorylation site was observed in the ventral striatum, selectively in the nucleus accumbens shell region, following chronic ethanol drinking [21].…”

Section: Introductionmentioning

confidence: 92%

Individual Differences in Ethanol Drinking and Seeking Behaviors in Rats Exposed to Chronic Intermittent Ethanol Vapor Exposure is Associated with Altered CaMKII Autophosphorylation in the Nucleus Accumbens Shell

Somkuwar

Mandyam

2019

Brain Sciences

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Chronic intermittent ethanol vapor exposure (CIE) in rodents produces reliable and high blood ethanol concentration and behavioral symptoms associated with moderate to severe alcohol use disorder (AUD)-for example, escalation of operant ethanol self-administration, a feature suggestive of transition from recreational to addictive use, is a widely replicated behavior in rats that experience CIE. Herein, we present evidence from a subset of rats that do not demonstrate escalation of ethanol self-administration following seven weeks of CIE. These low responders (LR) maintain low ethanol self-administration during CIE, demonstrate lower relapse to drinking during abstinence and reduced reinstatement of ethanol seeking triggered by ethanol cues when compared with high responders (HR). We examined the blood ethanol levels in LR and HR rats during CIE and show higher levels in LR compared with HR. We also examined peak corticosterone levels during CIE and show that LR rats have higher levels compared with HR rats. Lastly, we evaluated the levels of Ca 2+ /calmodulin-dependent protein kinase II (CaMKII) in the nucleus accumbens shell and reveal that the activity of CaMKII, which is autophosphorylated at site Tyr-286, is significantly reduced in HR rats compared with LR rats. These findings demonstrate that dysregulation of the hypothalamic-pituitary-adrenal axis activity and plasticity-related proteins regulating molecular memory in the nucleus accumbens shell are associated with higher ethanol-drinking and -seeking in HR rats. Future mechanistic studies should evaluate CaMKII autophosphorylation-dependent remodeling of glutamatergic synapses in the ventral striatum as a plausible mechanism for the CIE-induced enhanced ethanol drinking and seeking behaviors.

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“…Kawasaki et al, 2015Kawasaki et al, , 2017Ketcha Wanda et al, 2015;Listowska et al, 2015;Liu et al, 2015Liu et al, , 2019Nunes et al, 2015;Rilett et al, 2015;Thompson et al, 2015;Wensheng et al, 2015;Zagorácz et al, 2015;Biagioni et al, 2016;Dagan et al, 2016; Dos Anjos et al, 2016; Estork et al, 2016; Figueiredo et al, 2016;Girard et al, 2016;Gomez et al, 2016;Horsley et al, 2016;Lecorps et al, 2016;Li K. et al, 2016;Martins-Júnior et al, 2016;Miller et al, 2016;Onaolapo et al, 2016; Psyrdellis et al, 2016a,b;Saré et al, 2016;Schambra et al, 2016;Tran and Keele, 2016;Wscieklica et al, 2016;Bahi, 2017b;Blankenship et al, 2017;Casarrubea et al, 2017; Donatti et al, 2017;Hansen et al, 2017;Kawabe, 2017;Khalil and Fendt, 2017;Kuniishi et al, 2017;Machado et al, 2017;Mazur et al, 2017;Rangel-Barajas et al, 2017;Reinhart et al, 2017;Sanguedo et al, 2017;Santangelo et al, 2017;Santos et al, 2017;…”

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confidence: 99%

Under or Absent Reporting of Light Stimuli in Testing of Anxiety-Like Behaviors in Rodents: The Need for Standardization

Neuwirth

Verrengia

Harikinish-Murrary

et al. 2022

Front. Mol. Neurosci.

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Behavioral neuroscience tests such as the Light/Dark Test, the Open Field Test, the Elevated Plus Maze Test, and the Three Chamber Social Interaction Test have become both essential and widely used behavioral tests for transgenic and pre-clinical models for drug screening and testing. However, as fast as the field has evolved and the contemporaneous involvement of technology, little assessment of the literature has been done to ensure that these behavioral neuroscience tests that are crucial to pre-clinical testing have well-controlled ethological motivation by the use of lighting (i.e., Lux). In the present review paper, N = 420 manuscripts were examined from 2015 to 2019 as a sample set (i.e., n = ~20–22 publications per year) and it was found that only a meager n = 50 publications (i.e., 11.9% of the publications sampled) met the criteria for proper anxiogenic and anxiolytic Lux reported. These findings illustrate a serious concern that behavioral neuroscience papers are not being vetted properly at the journal review level and are being released into the literature and public domain making it difficult to assess the quality of the science being reported. This creates a real need for standardizing the use of Lux in all publications on behavioral neuroscience techniques within the field to ensure that contributions are meaningful, avoid unnecessary duplication, and ultimately would serve to create a more efficient process within the pre-clinical screening/testing for drugs that serve as anxiolytic compounds that would prove more useful than what prior decades of work have produced. It is suggested that improving the standardization of the use and reporting of Lux in behavioral neuroscience tests and the standardization of peer-review processes overseeing the proper documentation of these methodological approaches in manuscripts could serve to advance pre-clinical testing for effective anxiolytic drugs. This report serves to highlight this concern and proposes strategies to proactively remedy them as the field moves forward for decades to come.

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Alcohol consumption increases locomotion in an open field and induces Fos-immunoreactivity in reward and approach/withdrawal-related neurocircuitries

Cited by 18 publications

References 82 publications

Maternal voluntary physical activity attenuates delayed neurodevelopment in malnourished rats

Maternal voluntary physical activity attenuates delayed neurodevelopment in malnourished rats

Individual Differences in Ethanol Drinking and Seeking Behaviors in Rats Exposed to Chronic Intermittent Ethanol Vapor Exposure is Associated with Altered CaMKII Autophosphorylation in the Nucleus Accumbens Shell

Under or Absent Reporting of Light Stimuli in Testing of Anxiety-Like Behaviors in Rodents: The Need for Standardization

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