Alcohol Consumption, High-Density Lipoprotein Cholesterol, Antithrombin III, and Body Mass Index Are Associated with Great Saphenous Vein Reflux in the Thigh

Kim, Hyeonseung; Kim, Hyangkyoung; Park, Je Hoon; Kim, Yong Han; Oh, Sung Jin; Suh, Byoung Jo; Park, Jong Kwon

doi:10.1016/j.avsg.2017.05.004

Cited by 4 publications

(2 citation statements)

References 26 publications

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“…Since antithrombin III is a natural anticoagulant produced in the liver and inhibits numerous clotting factors, reduced production with increasing FLI leads to increased interference with the coagulation cascade. This may eventually increase the risk of thrombosis and subsequently of other diseases [ 27 ]. aPTT is a coagulation test based on partial thromboplastin time and is used clinically to indicate abnormalities within the coagulation system [ 11 ].…”

Section: Discussionmentioning

confidence: 99%

Association between fatty liver index and blood coagulation markers: a population-based study

et al. 2023

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Background Population-based studies investigating the association between blood coagulation markers and non-alcoholic fatty liver disease (NAFLD) are rare. Thus, we aimed to investigate the relationship between the Fatty Liver Index (FLI) as a measure of hepatic steatosis and plasma concentrations of antithrombin III, D-dimer, fibrinogen D, protein C, protein S, factor VIII, activated partial thromboplastin time (aPTT), quick value and international thromboplastin time (INR) in the general population. Methods After the exclusion of participants with anticoagulative treatment, 776 participants (420 women and 356 men, aged 54–74 years) of the population-based KORA Fit study with analytic data on hemostatic factors were included in the present analysis. Linear regression models were used to explore the associations between FLI and hemostatic markers, adjusted for sex, age, alcohol consumption, education, smoking status, and physical activity. In a second model, additional adjustments were made for the history of stroke, hypertension, myocardial infarction, serum non-HDL cholesterol levels, and diabetes status. In addition, analyses were stratified by diabetes status. Results In the multivariable models (with or without health conditions), significantly positive associations with FLI were obtained for plasma concentrations of D-dimers, factor VIII, fibrinogen D, protein C, protein S, and quick value, while INR and antithrombin III were inversely associated. These associations were weaker in pre-diabetic subjects and largely disappeared in diabetic patients. Conclusion In this population-based study, an increased FLI is clearly related to changes in the blood coagulation system, possibly increasing the risk of thrombotic events. Due to a generally more pro-coagulative profile of hemostatic factors, such an association is not visible in diabetic subjects.

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Section: Discussionmentioning

confidence: 99%

Association between fatty liver index and blood coagulation markers: a population-based study

et al. 2023

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“…Antithrombin III is a glycoprotein belonging to the group of serine protease inhibitors. By inhibiting several factors of the coagulation system, especially thrombin, and factors VIIa, IXa, Xa, Xia, and XIIa, antithrombin III holds a central role in regulating the coagulation cascade [ 23 ]. Low levels of antithrombin III lead to a very high risk of thrombosis [ 24 ] and can also suggest reduced synthesis and underlying liver disease [ 25 ].…”

Section: Discussionmentioning

confidence: 99%

Body Mass Index and Waist Circumference as Determinants of Hemostatic Factors in Participants of a Population-Based Study

et al. 2023

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Background: In contrast to studies in patients, an association between obesity and blood coagulation factors has not been established in the population. If confirmed it could become a target for primary prevention. Objective: To investigate the relationship between Body Mass Index (BMI) and waist circumference (WC) with plasma concentrations of antithrombin III, D-dimers, fibrinogen D, protein S, factor VIII, activated partial thromboplastin time (aPTT), quick value, and international normalized ratio (INR) in the general population. Materials and Methods: Participants of the Cooperative Health Research in the Region of Augsburg (KORA) S4 study who took part in the KORA Fit follow-up (2018–2019, aged 54–74 years) examination were eligible. Citrate plasma samples were collected in fasted participants. After the exclusion of participants with anticoagulative treatment, 776 participants (420 women and 356 men) with analytic data on hemostatic factors were included in the present analysis. Linear regression models were used to explore the association between BMI or WC with hemostatic markers, adjusted for sex, age, alcohol consumption, education, smoking status, and physical activity. In a second model, additional adjustments were made for the prevalence of stroke, hypertension, myocardial infarction, serum non-HDL cholesterol, and serum triglycerides. Results: In the multivariable models (with or without health conditions), significant positive associations with BMI were obtained for plasma concentrations of D-dimers, factor VIII, fibrinogen D, protein S, and quick value, while INR and antithrombin III were inversely associated. Similar to BMI, WC was significantly associated with all hemostatic factors, except for aPTT. Conclusion: In this population-based study, both increasing BMI and WC affect the blood coagulation system. Thus, modification of a prothrombotic coagulation profile emerged as a potential target for primary prevention in obese subjects.

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Comparison of Clinical and Hematologic Factors Associated with Stenosis and Aneurysm Development in Patients with Atherosclerotic Arterial Disease

Park

Kim

Park

2019

Annals of Vascular Surgery

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Alcohol Consumption, High-Density Lipoprotein Cholesterol, Antithrombin III, and Body Mass Index Are Associated with Great Saphenous Vein Reflux in the Thigh

Cited by 4 publications

References 26 publications

Association between fatty liver index and blood coagulation markers: a population-based study

Association between fatty liver index and blood coagulation markers: a population-based study

Body Mass Index and Waist Circumference as Determinants of Hemostatic Factors in Participants of a Population-Based Study

Comparison of Clinical and Hematologic Factors Associated with Stenosis and Aneurysm Development in Patients with Atherosclerotic Arterial Disease

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