Alcohol consumption enhances liver metastasis in colorectal carcinoma patients

Maeda, Mamoru; Nagawa, Hirokazu; Maeda, Tsuneo; Koike, Hideo; Kasai, Hide

doi:10.1002/(sici)1097-0142(19981015)83:8<1483::aid-cncr2>3.0.co;2-z

Cited by 35 publications

(28 citation statements)

References 32 publications

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“…Also, it identified as an independent risk factor for liver metastasis in CRC in this study. Similar result was previously reported by Maeda et al (1998). Liver injury, effects on platelets, suppression of natural killer cells, and/or elevation of the blood gastrin level in response to alcohol consumption were possible interpretation for liver metastasis of CRC (Maeda et al, 1998).…”

Section: Discussionsupporting

confidence: 88%

Serum Carbohydrate Antigen 19-9 as an Indicator of Liver Metastasis in Colorectal Carcinoma Cases

Hang

Tang²,

Li³

et al. 2013

Asian Pacific Journal of Cancer Prevention

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Purpose: The liver is the organ to which colorectal carcinomas (CRCs) most commonly metastasize, and surgical resection has been established as the most effective and potentially curative treatment for CRC with liver metastasis (LM). Therefore, surveillance of LM is vital for improvement of prognosis of CRC patients. In this study, we aimed to explore the potential value of carbohydrate antigen 19-9 (CA 19-9), carcinoembryonic antigen (CEA), and marker enzymes in indicating LM with CRC. Methods: Three groups of eligible patients with metastatic cancers were retrospectively included: CRC patients with LM (CRC-LM) or without LM (CRC-NLM), and non-CRC patients with LM (NCRC-LM). All metastatic lesions were identified by CT or MRI. Data on characteristics of the patients, the primary site, the locations of metastasis, CA 19-9, CEA, and biochemical parameters were collected for analysis. Results: A total of 493 patients were retrospectively included. More alcohol consumption was found in CRC-LM than CRC-NLM. Some biochemical enzymes were found to be significantly higher in groups with LM than without (CRC-LM or NCRC-LM v.s CRC-NLM). Both CEA and CA 19-9 were much higher in CRC-LM than CRC-NLM or NCRC-LM. For CRC patients, CA 19-9, γ-glutamyl transpeptidase, CEA and alcohol consumption were identified as independent factors associated with LM. Conclusion: Our analysis suggested the CA 19-9 might be a potential valuable indicator for LM of CRC in the clinic.

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Section: Discussionsupporting

confidence: 88%

Serum Carbohydrate Antigen 19-9 as an Indicator of Liver Metastasis in Colorectal Carcinoma Cases

Hang

Tang²,

Li³

et al. 2013

Asian Pacific Journal of Cancer Prevention

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“…In human studies, patients with colorectal carcinoma who use alcohol seem to have higher cancer-related mortality rates due to a greater development of liver metastases (34). No support for these findings was found in our study.…”

Section: Discussioncontrasting

confidence: 78%

Effect of ethanol consumption on colon cancer in an experimental model

Pérez-Holanda¹,

Rodrigo

Salas

et al. 2005

Rev. esp. enferm. dig.

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Pérez-Holanda S, Rodrigo L, Viñas-Salas J, Piñol-Felis C. Effect of ethanol consumption on colon cancer in an experimen tal model. Rev Esp Enferm Dig 2003; 95: 87-96. ABSTRACTAims: the present study was designed to examine the effect of an ethanol supplement on experimental colon carcinogenesis.Material and methods: one hundred and ten 10-week-old Sprague-Dawley rats were divided into five groups: group A (20 rats) received no treatment. Group B (20 rats) received a supplement of ethanol at 1.23 g/kg of body weight per day added to their drinking water for 24 weeks. Group C (30 rats) received 18 weekly doses of dimethylhydrazine (DMH) at 21 mg/kg of body weight from the beginning of the study. Group D (20 rats) received ethylen-diamin-tetracetic acid (EDTA) solution only for 18 weeks. Group E (20 rats) received ethanol at the same dose as group B plus DMH injections at the same dose as the rats in group C from the beginning of the study. All experimental animals were sacrified after 25-27 weeks.Results: no significant differences in the number of rats that developed tumors, number of tumor-free animals, and number of tumors per rat, as well as in macro-microscopic tumoral findings were observed for animals in group C compared to animals in group E.Conclusions: we concluded that the addition of an ethanol supplement does not modify colorectal carcinogenesis using a dynamic model of tumor induction with DMH.

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“…High consumption of alcohol has been shown to enhance the invasion and metastasis of breast cancer, colon cancer, and liver cancer (1)(2)(3)(4)(5). Conversely, moderate alcohol consumption has also been shown to protect against the incidence of cardiovascular diseases (6).…”

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confidence: 99%