Alcohol Consumption Does not Impede Recovery from Mild to Moderate Traumatic Brain Injury

Silverberg, Noah D.; Panenka, William J.; Brubacher, Jeffrey R.; Shewchuk, Jason R.; Heran, Manraj K.S.; Oh, Gary Chee Seng; Honer, William G.; Lange, Rael T.

doi:10.1017/s1355617716000692

Cited by 9 publications

(3 citation statements)

References 74 publications

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“…For more details of the participant selection process and exclusion criteria see Silverberg et al. (2016). A flow‐chart describing the selection process is available in the Supporting Information as Figure S1).…”

Section: Methodsmentioning

confidence: 99%

Longitudinal changes in brain parenchyma due to mild traumatic brain injury during the first year after injury

et al. 2021

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Chronic gray matter (GM) atrophy is a known consequence of moderate and severe traumatic brain injuries but has not been consistently shown in mild traumatic brain injury (mTBI). The aim of this study was to investigate the longitudinal effect of uncomplicated mTBI on the brain's GM and white matter (WM) from 6 weeks to 12 months after injury. Voxel-based-morphometry (VBM) was computed with the T1-weighted images of 48 uncomplicated mTBI patients and 37 orthopedic controls. Over the period from 6 weeks to 12 months, only patients who experienced uncomplicated mTBI, but not control participants, showed significant GM decrease predominantly in the right hemisphere along the GM-CSF border in lateral and medial portions of the sensorimotor cortex extending into the rolandic operculum, middle frontal gyrus, insula, and temporal pole. Additionally, only mTBI patients, but not controls, experienced significant WM decrease predominantly in the right hemisphere in the superior fasciculus longitudinalis, arcuate fasciculus, and cortical-pontine tracts as well as a significant WM increase in left arcuate fasciculus and left capsula extrema. We did not observe any significant change in the controls for the same time interval or any significant group differences in GM and WM probability at each of the two timepoints. This suggests that the changes along the brain tissue borders observed in the mTBI group represent a reorganization associated with subtle microscopical changes in intracortical myelin and not a direct degenerative process as a result of mTBI.

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Section: Methodsmentioning

confidence: 99%

Longitudinal changes in brain parenchyma due to mild traumatic brain injury during the first year after injury

et al. 2021

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“…For example, one study showed that preinjury, acute alcohol intoxication, and postinjury alcohol use did not influence symptom severity or neurocognitive outcomes a year after mild-to-moderate TBI. 19 Another showed that postinjury alcohol use did not affect postconcussion symptom scores 4 weeks after injury. 21 Similar to our study, these findings were limited by recall bias and self-reported symptom scores.…”

Section: Discussionmentioning

confidence: 99%

“…Some have shown that alcohol use after mild or moderate TBI improves or has no effect on recovery outcomes. [19][20][21] Others suggest that alcohol consumption can worsen outcomes after TBI. 22,23 For example, alcohol consumption (primarily in patients with chronic alcohol use and/or acute intoxication) has been associated with longer episodes of posttraumatic amnesia, alterations in cerebral metabolism, [24][25][26] brain atrophy on magnetic resonance imaging, and difficulty with learning and memory after TBI with varying degrees of severity (mild, moderate, and severe).…”

Section: Introductionmentioning

confidence: 99%

Postinjury Alcohol Use Is Associated With Prolonged Recovery After Concussion in NCAA Athletes

Chang

Singleton

Chrisman

et al. 2023

Clinical Journal of Sport Medicine

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Objective: To determine whether alcohol use leads to prolonged clinical recovery or increased severity of concussion symptoms in National Collegiate Athletic Association (NCAA) athletes. Design: Prospective observational study. Setting: Clinical institutions. Participants: Athletes from the NCAA Concussion Assessment Research and Education consortium who sustained a concussion from 2014 to 2021. Interventions: Athletes were divided into 2 groups, those reporting alcohol use postinjury and those reporting no alcohol use postinjury. Main Outcome Measures: Symptom recovery was evaluated as time (in days) from injury to clearance to return to unrestricted play (days until URTP). Severity of concussion symptoms was assessed using the Standardized Sport Concussion Assessment Tool (SCAT3) symptom severity, headache severity, difficulty concentrating, and difficulty remembering scores. These scores were taken a median of 6.6 [interquartile range (IQR) = 4.0-10] and 6 (IQR = 4.0-9.0) days after injury for those who did and did not consume alcohol postinjury respectively and compared with baseline SCAT3 scores. Results: Four hundred eighty four athletes from the data set had complete data for exposure and outcome. The adjusted mean number of days until URTP for athletes reporting alcohol use postinjury [23.3; 95% confidence interval (CI), 20.0-27.2; days] was incidence rate ratio (IRR) 1.32 (95% CI, 1.12-1.55; P < 0.001) times higher than for athletes who reported no alcohol use postinjury [17.7 (95% CI, 16.1-19.3) days]. Postinjury alcohol was not associated with severity of concussion symptoms (P's < 0.05). Conclusion: Self-reported postinjury alcohol use is associated with prolonged recovery but not severity of concussion symptoms in collegiate athletes. This may inform future clinical recommendations regarding alcohol consumption after concussion.

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Concussion

Duquette¹,

Spotts²

2020

Principles and Practice of College Health

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Alcohol Consumption Does not Impede Recovery from Mild to Moderate Traumatic Brain Injury

Abstract: Alcohol may not significantly alter long-term outcome from mild to moderate TBI. (JINS, 2016, 22, 816-827).

Cited by 9 publications

References 74 publications

Longitudinal changes in brain parenchyma due to mild traumatic brain injury during the first year after injury

Longitudinal changes in brain parenchyma due to mild traumatic brain injury during the first year after injury

Postinjury Alcohol Use Is Associated With Prolonged Recovery After Concussion in NCAA Athletes

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