Alcohol consumption, coronary calcium, and coronary heart disease events

Yang, Ted; Doherty, Terence M.; Wong, Nathan D.; Detrano, Robert

doi:10.1016/s0002-9149(99)00440-3

Cited by 34 publications

(26 citation statements)

References 14 publications

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“…So far, only one study investigated whether alcohol consumption was associated with coronary calcification. In 1196 high-risk subjects no association was found between alcohol consumption and coronary calcification [26].…”

Section: Cardiovascular Risk Factors and Coronary Calcificationmentioning

confidence: 91%

“…Population-based follow-up studies have shown that moderate alcohol consumption diminishes the risk of coronary heart disease [26][27][28][29][30]. Although it has been postulated that alcohol increases HDL cholesterol levels, the mechanism by which alcohol intake exerts this effect is not well understood.…”

Section: Cardiovascular Risk Factors and Coronary Calcificationmentioning

confidence: 99%

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Non-invasive assessment of coronary calcification

Vliegenthart¹,

Oei²,

Hofman³

et al. 2004

Eur J Epidemiol

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Electron-beam tomography (EBT) and multi-detector computed tomography (MDCT) enable the noninvasive assessment of coronary calcification. The amount of coronary calcification, as detected by EBT, has a close relation with the amount of coronary atherosclerosis, which is the substrate for the occurrence of myocardial infarction and sudden cardiac death. Calcification of the coronary arteries can be seen as a cumulative measure of life-time exposure to cardiovascular risk factors. Several studies have shown that the amount of coronary calcification is associated with the risk of coronary heart disease. Therefore, coronary calcification is a promising method for non-invasive detection of asymptomatic subjects at high risk of developing coronary heart disease. Whether measurement of coronary calcification also increases the predictive power of coronary events based on cardiovascular risk factors is topic of current research.

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Section: Cardiovascular Risk Factors and Coronary Calcificationmentioning

confidence: 91%

Section: Cardiovascular Risk Factors and Coronary Calcificationmentioning

confidence: 99%

Non-invasive assessment of coronary calcification

Vliegenthart¹,

Oei²,

Hofman³

et al. 2004

Eur J Epidemiol

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“…Calcification may actually reflect stabilisation and maturation of atherosclerotic plaques and hence lead to fewer myocardial infarctions and CAD deaths. [11][12][13][14][15][16][17][18][19][20] In this study, we describe the association of pericardial fat volume with coronary artery disease showing its association between coronary artery stenosis and also coronary calcium score. Thereby, we hope to provide additional evidence towards the already existing dispute of whether or not the pericardial fat volume should be considered a risk factor or a predictor for coronary artery disease.…”

Section: Introductionmentioning

confidence: 92%

Ct Evaluation of Association Between Pericardial Fat Volume and Coronary Artery Disease

Alias¹,

K²,

Mathew³

et al. 2017

jemds

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BACKGROUNDPericardial fat is the adipose tissue surrounding the heart. It releases inflammatory cytokines in a local fashion and affect only the adjacent structures, which are coronary arteries. Multiple studies have tried to establish the association of pericardial fat volume and calcium scoring with the incidence of coronary artery disease with contradicting results. We hope to provide additional evidence towards this already existing dispute and to comment whether pericardial fat volume measurement should be done as a routine diagnostic tool and consider it as a marker for ischaemic heart disease.The objective of this study is to evaluate the association between pericardial fat volume and coronary artery disease using dual source computed tomography (DSCT), to evaluate the pericardial fat volume differences between patients with coronary artery disease and normal controls, to assess the relationship between pericardial fat volume and coronary calcium score and between different degrees of coronary artery stenosis. MATERIALS AND METHODSWe included 117 DSCT coronary angiography studies, of which 62 cases were males and 55 were females; 74 scans showed positive findings of coronary artery disease and 43 cases were normal. Both the presence of coronary calcium score and/or coronary artery stenosis was taken into consideration as positive radiological findings of coronary artery disease. The scans were taken using Siemens Somatom definition flash DSCT with 100 kVp, 0.75 mm slice thickness and mAs according to the patient's BMI. The scans were obtained in diastolic phase with the patient in supine position. Contrast agent used was Visipaque. Pericardial fat volume was measured in Siemens Somatom Syngo volume analysis software. The area of interest was taken as the areas of pericardial fat around the main coronary arteries and the threshold HU was kept between -30 and -190 HU. Coronary artery stenosis was assessed visually by two experienced radiologists and categorised to mild (< 50%), moderate (50% -75%) and severe (>75%). Coronary artery calcium score (Agatston score) was calculated using Siemens calcium score analysis software by an experienced radiologist. Each coronary artery was selected and the sum of all the calcium score of all the arteries were taken as total coronary calcium score. The data was written in excel format. All the statistics was done in SPSS 16.0 software. RESULTSThe retrospective analysis of 117 CT coronary angiography scans revealed 74 (63.24%) cases with positive findings for coronary artery disease either having coronary calcification or coronary artery stenosis. The mean of pericardial fat volume for normal cases was 76.84 ± 35.79 cm 3 and the positive cases with the evidence of coronary artery disease were 92.95 ± 35.84 cm 3 . Significant differences were observed between the pericardial fat volume of normal subjects and subjects with the evidence of coronary artery disease in student t-test (P= 0.023). Pericardial fat volume was observed to have no significant difference betw...

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“…Adjustment for multiple risk factors is important because CAC is itself related to multiple CAD risk factors (see above), and the importance of CAC screening lies in its potential ability to increase predictive power for events beyond that provided by the Framingham risk score (54). Although Pletcher et al (85) felt that the studies reviewed justified further use of CAC for risk stratification, three of the four communications were from referral populations (86,87,89) and only one directly measured lipids (88), but that sample included diabetic patients (who would be automatically categorized as at the highest risk by the ATP III guidelines). In addition, that study (88) did not exclude patients with Framingham risk scores .…”

Section: Coronary Calcification and Clinical Outcomementioning

confidence: 99%

Thematic review series: Patient-Oriented Research. Imaging atherosclerosis: state of the art

Crouse

2006

Journal of Lipid Research

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The ability to image obstructive arterial disease brought about a revolution in clinical cardiovascular care; the development of newer technologies that image arterial wall thicknesses, areas, volumes, and composition allows valid imaging of atherosclerosis for the first time. Development of noninvasive imaging of atherosclerosis has further led to a quantum shift in research in the field by enabling the study of asymptomatic populations and thus allowing investigators to focus on preclinical disease without the many biases associated with the study of symptomatic patients. These noninvasive investigations have broad implications for clinical care as well. Coronary angiography, computed tomographic (CT) imaging of coronary calcium, intravascular ultrasound, multidetector CT angiography, B mode ultrasound of the carotid arteries, and MRI of the carotid arteries all have unique strengths and weaknesses for imaging atherosclerosis. Certain of these techniques are extremely useful as outcome variables for clinical trials, and others are uniquely useful as predictors of the risk of cardiovascular disease. All are informative in one way or another with regard to the role of plaque remodeling and composition in disease causation. CT and MRI technology are advancing very rapidly, and research and clinical uses of these imaging modalities promise to further advance our understanding of atherosclerosis and its prevention.-Crouse, J. R., III. Imaging atherosclerosis: state of the art.

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Alcohol consumption, coronary calcium, and coronary heart disease events

Cited by 34 publications

References 14 publications

Non-invasive assessment of coronary calcification

Non-invasive assessment of coronary calcification

Ct Evaluation of Association Between Pericardial Fat Volume and Coronary Artery Disease

Thematic review series: Patient-Oriented Research. Imaging atherosclerosis: state of the art

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