Alcohol consumption and well-being among 25,000 Danish high school students

Alcohol-induced liver injury in signalling pathways and curcumin's therapeutic potential

“…The progression of ALD, which includes fatty liver, alcohol-related hepatitis, and cirrhosis, is chiefly instigated by the hepatotoxic properties of alcohol, which sets off a series of adverse metabolic responses. The formerly held belief that malnutrition is the main driver behind ALD has been replaced by the understanding that alcohol metabolism is the primary trigger of a complex pathological sequence involving protein-aldehyde adduct formation, immune activation, lipid peroxidation, and cytokine release [27] , [28] , [29] . Emerging evidence underscores the significance of the liver-gut axis, emphasizing its substantial interaction with the gut microbiota.…”

Mental health and well-being for the prevention of substance use disorders

“…A cross-sectional study, which used data from the Danish National Youth Study 2019 (25,910 students aged 15–25 years), found that there was a U-shaped association between weekly alcohol consumption and poor well-being; for example, students who never drank, students who only drank occasionally, and students who drank a lot (22 units of alcohol or more a week) had higher odds of poor well-being, compared with the reference group (1–7 units a week). [ 1 ]…”