Alcohol consumption and risk of melanoma and non-melanoma skin cancer in the Women’s Health Initiative

Kubo, Jessica; Henderson, Michael T.; Desai, Manisha; Wactawski‐Wende, Jean; Stefanick, Marcia L.; Tang, Jean Y.

doi:10.1007/s10552-013-0280-3

Cited by 46 publications

(61 citation statements)

References 25 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…(26–27) Our findings also support those of a previous study by Kubo et al, in which preference for white wine was associated with increased risk of melanoma and non-melanoma skin cancer in the Women’s Health Initiative, a cohort of postmenopausal women. (59). A pooled analysis of eight case-control studies also found that among alcoholic beverages, wine was most strongly associated with melanoma risk (OR=1.4, 95% CI 1.1–1.8 for ever consumption vs. never) (47).…”

Section: Discussionmentioning

confidence: 99%

Alcohol Intake and Risk of Incident Melanoma: A Pooled Analysis of Three Prospective Studies in the United States

Rivera

Nan

et al. 2016

Cancer Epidemiology, Biomarkers &Amp; Prevention

View full text Add to dashboard Cite

Background Alcohol consumption is associated with increased risk of numerous cancers, but existing evidence for an association with melanoma is equivocal. No study has evaluated the association with different anatomic locations of melanoma. Methods We used data from three large prospective cohort studies to investigate whether alcohol intake was associated with risk of melanoma. Alcohol intake was assessed repeatedly by food-frequency questionnaires. A Cox proportional hazards model was used to calculate multivariate-adjusted hazard ratios (HRs). Results A total of 1,374 cases of invasive melanoma were documented during 3,855,706 person-years of follow-up. There was an association between higher alcohol intake and incidence of invasive melanoma (pooled multivariate HR 1.14; 95% confidence interval [CI]: 1.00–1.29] per drink/d, p trend = 0.04). Among alcoholic beverages, white wine consumption was associated with an increased risk of melanoma (pooled multivariate HR 1.13 [95% CI: 1.04–1.24] per drink/d, p trend <0.01) after adjusting for other alcoholic beverages. The association between alcohol consumption and melanoma risk was stronger for melanoma in relatively UV-spared sites (trunk) versus more UV-exposed sites (head, neck, or extremities). Compared to non-drinkers, the pooled multivariate-adjusted HRs for ≥20g/d of alcohol were 1.02 (95% CI: 0.64–1.62; P trend =0.25) for melanomas of the head, neck, and extremities and 1.73 (95% CI: 1.25–2.38; P trend =0.02) for melanomas of the trunk. Conclusions Alcohol intake was associated with a modest increase in the risk of melanoma, particularly in UV-protected sites. Impact These findings further support American Cancer Society Guidelines for Cancer Prevention to limit alcohol intake.

show abstract

Section: Discussionmentioning

confidence: 99%

Alcohol Intake and Risk of Incident Melanoma: A Pooled Analysis of Three Prospective Studies in the United States

Rivera

Nan

et al. 2016

Cancer Epidemiology, Biomarkers &Amp; Prevention

View full text Add to dashboard Cite

show abstract

“…Chronic alcohol consumption increases the incidence of multiple types of cancer including melanoma [1-9]. The effects of alcohol consumption on cancer can be divided into two equal important aspects.…”

Section: Introductionmentioning

confidence: 99%

Chronic alcohol consumption inhibits melanoma growth but decreases the survival of mice immunized with tumor cell lysate and boosted with α-galactosylceramide

Zhang

Zhu

Meadows

et al. 2015

International Immunopharmacology

View full text Add to dashboard Cite

Alcohol consumption increases the incidence of multiple types of cancer. However, how chronic alcohol consumption affects tumor progression and host survival remains largely unexplored. Using a mouse B16BL6 melanoma model, we studied the effects of chronic alcohol consumption on s.c. tumor growth, iNKT cell antitumor immune response, and host survival. The results indicate that although chronic alcohol consumption inhibits melanoma growth, this does not translate into increased host survival. Immunizing mice with a melanoma cell lysate does not significantly increase the median survival of water-drinking, melanoma-bearing mice, but significantly increases the median survival of alcohol-consuming, melanoma-bearing mice. Even though survival is extended in the alcohol-consuming mice after immunization, the mean survival is not different from the immunized mice in the water-drinking group. Immunization with tumor cell lysate combined with α-galatosylceramide activation of iNKT cells significantly increases host survival of both groups of melanoma-bearing mice compared to their respective non-immunized counterparts; however, the median survival of the alcohol-consuming group is significantly lower than that of the water-drinking group. Alcohol consumption increases NKT cells in the thymus and blood and skews NKT cell cytokine profile from Th1 dominant to Th2 dominant in the tumor-bearing mice. In summary, these results indicate that chronic alcohol consumption activates the immune system, which leads to the inhibition of s.c. melanoma growth and enhances the immune response to immunization with melanoma lysate. With tumor progression, alcohol consumption accelerates iNKT cell dysfunction and compromises antitumor immunity, which leads to decreased survival of melanoma-bearing mice.

show abstract

“…Furthermore, given that the development of skin cancer depends on both sun exposure and constitutional factors, it is possible that sun exposure may interact with host risk profile to alter an individual's skin cancer risk. More recent studies also revealed that lifestyle-related factors, such as artificial tanning bed use (17-19), weight change (20,21), smoking (22,23), alcohol intake (24,25), physical activity (26,27), and rotating nights shifts (28), may also modify risks of different skin cancers. Currently a comprehensive assessment is lacking for the relationships between chronic sun exposure based on residential history, as well as sun exposure in early life, and risk of different types of skin cancer.…”

mentioning

confidence: 99%

Long-term Ultraviolet Flux, Other Potential Risk Factors, and Skin Cancer Risk: A Cohort Study

Han

Laden

et al. 2014

Cancer Epidemiology, Biomarkers &Amp; Prevention

135

111

View full text Add to dashboard Cite

Background Few prospective studies have examined the relationship between sun exposure, other potential risk factors, and risk of different skin cancers [including basal cell carcinoma (BCC), squamous cell carcinoma (SCC), and melanoma] simultaneously. Methods We evaluated the association between a number of potential risk factors and skin cancer risk in a cohort of 108,916 US women, the Nurses’ Health Study II (1989-2009). Results During 2.05 million years of follow-up, we identified 6,955, 880, and 779 diagnoses of BCC, SCC, and melanoma, respectively. Compared to participants in the lowest quintile of cumulative ultraviolet flux in adulthood, participants in the highest quintile had multivariable-adjusted relative risks (RR) of 2.35 (Ptrend<0.0001) for BCC, 2.53 (Ptrend=0.009) for SCC, and 0.68 (Ptrend=0.38) for melanoma. In contrast, the RRs were 1.68 (95%CI: 1.55-1.82) for BCC, 1.68 (95%CI: 1.34-2.11) for SCC and 1.80 (95%CI: 1.42-2.28) for melanoma for participants with ≥5 blistering sunburns when compared to participants without sunburn between ages 15-20. We found significant interactions between family history of melanoma, number of blistering sunburns between ages 15-20 and BCC risk, and between sunburn reaction as a child/adolescent and SCC risk (all Pinteraction<0.05). Conclusion In a cohort of US women, we found that sun exposures in both early life and adulthood were predictive of BCC and SCC risks, whereas melanoma risk was predominantly associated with sun exposure in early life. Impact Our results may have potential implications for the prevention of skin cancers.

show abstract

Alcohol consumption and risk of melanoma and non-melanoma skin cancer in the Women’s Health Initiative

Cited by 46 publications

References 25 publications

Alcohol Intake and Risk of Incident Melanoma: A Pooled Analysis of Three Prospective Studies in the United States

Alcohol Intake and Risk of Incident Melanoma: A Pooled Analysis of Three Prospective Studies in the United States

Chronic alcohol consumption inhibits melanoma growth but decreases the survival of mice immunized with tumor cell lysate and boosted with α-galactosylceramide

Long-term Ultraviolet Flux, Other Potential Risk Factors, and Skin Cancer Risk: A Cohort Study

Contact Info

Product

Resources

About