Alcohol consumption and risk of incident atrial fibrillation: A population-based cohort study

Johansson, Cecilia; Lind, Marcus; Eriksson, Marie; Wennberg, Maria; Andersson, Jonas; Johansson, Lars

doi:10.1016/j.ejim.2020.02.022

Cited by 19 publications

(14 citation statements)

References 38 publications

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“…Considering the shortcomings of previous metaanalyses (9)(10)(11)14), the latest comprehensive meta-analysis of high-quality prospective studies and almost 10 million participants was conducted, along with subgroup and sensitivity analysis, to obtain more reliable results. Specifically, five more studies (12,13,15,16,31) involving a total of 9,943,654 participants with 202,301 cases were included in our study on the basis of the last meta-analysis published in 2014 (11). The newly included studies had lager sample sizes than those before, and two studies conducted dose-response analysis (12,13).…”

Section: Discussionmentioning

confidence: 99%

Alcohol consumption and atrial fibrillation risk: An updated dose-response meta-analysis of over 10 million participants

Jiang

Mei²,

Jiang³

et al. 2022

Front. Cardiovasc. Med.

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BackgroundThe treatment of atrial fibrillation (AF) has made significant progress, but the prevention of AF has not received the attention it deserves. A few recent large-sized studies have conducted dose response analysis and reported different conclusions from previous studies on alcohol consumption and AF risk.ObjectivesThe aim of this study is to examine the potential non-linear association between alcohol consumption and risk of AF and explore the potential differences of gender.MethodsIn this updated dose-response meta-analysis, PubMed, Embase and Cochrane databases were searched until June 2022. Risk estimates were reported as relative risk (RR) with 95% confidence intervals (CIs). The random-effects restricted cubic spline models are used to evaluate the potential non-linear association between alcohol consumption and AF risk.ResultsA total of 10,151,366 participants with 214,365 cases of AF enrolled in 13 prospective studies. The overall meta-analysis showed that a 1 drink/day increase in alcohol consumption increased the risk of AF by 6% (RR: 1.06; 95% CI: 1.03–1.08). In gender subgroup analysis, pooled results were different between men (RR: 1.08; 95% CI: 1.05–1.11) and women (RR: 1.05; 95% CI: 0.96–1.14). A linear relationship between alcohol consumption and risk of AF was found in men (p = 0.87) while a J-shaped curve was observed in women (p = 0.00). Regional subgroup analysis yielded broadly comparable results in Americas (RR: 1.07; 95% CI: 1.03–1.12), Europe (RR: 1.04; 95% CI: 0.99–1.1) and Asia (RR: 1.07; 95% CI: 0.99–1.14).ConclusionThe relationship between AF risk and alcohol consumption is linear in men, while a potential non-linear J-shaped relationship is shown in women.Condensed abstractWe conducted a dose-response meta-analysis on the relationship between alcohol consumption and risk of atrial fibrillation. We merged the data of over 10 million participants and found gender differences in the pattern of association with AF and alcohol consumption. The relationship between AF risk and alcohol consumption is linear in men, while a potential non-linear J-shaped relationship is shown in women. In summary, this research is vital in furthering our understanding of the role of alcohol consumption in new-onset AF, especially among different genders.

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Section: Discussionmentioning

confidence: 99%

Alcohol consumption and atrial fibrillation risk: An updated dose-response meta-analysis of over 10 million participants

Jiang

Mei²,

Jiang³

et al. 2022

Front. Cardiovasc. Med.

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“…Increasing evidence suggests that excessive alcohol consumption is associated with a higher risk of AF, 8,11,14 but other studies have reported contrasting results. [15][16][17][18] These contrasting results could be attributed to the fact that these studies did not quantify the amount of alcohol consumed and were characterized by small sample sizes.…”

Section: La Echocardiographic Changesmentioning

confidence: 99%

The role of alcohol consumption on echocardiographic and electrophysiologic changes in atrial fibrillation

et al. 2022

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Background: A wealth of evidence suggests that alcohol consumption is a risk factor for atrial fibrillation (AF); however, the mechanisms underlying this association are unclear. This makes it challenging to develop therapeutic strategies in patients with AF attributed to alcohol consumption. Purpose: To investigate the echocardiographic and electrophysiologic changes caused by alcohol consumption in patients with AF. Methods: The study was registered in Chinese Clinical Trial Registry (Registration number ChiCTR2000041575). Data on 134 consecutive non-valvular AF patients who underwent radiofrequency catheter ablation in our center was collected from April 1, 2019 to June 30, 2020. Patients were divided into no-alcohol (72) and alcohol groups [categorized into light (34), moderate (11) and heavy (17) alcohol consumption]. All patients underwent echocardiographic and electrophysiologic examinations for the assessment of left atrial (LA) strain, inter-atrial conduction, intra-atrial conduction, and atrial effective refractory period (ERP).Results: Overall, the mean age was 61 ± 11 years and 87 (65%) were males. Compared with the no-alcohol group, impaired peak LA longitudinal strain, obvious inter-atrial conduction delay and increasing ERP dispersion were observed in the alcohol group.Intra-atrial conduction delay and ERP dispersion increased with increasing amounts of alcohol consumption. Conclusion:Alcohol consumption was associated with substantial abnormal echocardiographic and electrophysiologic changes in AF patients. These changes may contribute to the occurrence and progression of AF attributed to alcohol consumption, which may help in the development of new strategies for the prevention and management of AF. However further investigation is required.

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“…The relationship between chronic moderate-to-high alcohol consumption and incident AF is well established, but an increased AF risk has not been consistently demonstrated at low or increased levels of alcohol consumption. [28][29][30][31][32][33][34][35] Although the study by Larsson et al 25 suggested a significant 8% AF risk increase in people consuming > 12 g alcohol per day, no significant increase in AF risk was seen at similar levels in other meta-analyses. 27,36 In addition to the results of these meta-analyses, 2 recent analyses of large cohorts focused further on this topic.…”

Section: Binge Drinking and Holiday Heart Syndromementioning

confidence: 99%

“…Several studies could not show an increase in AF risk across all alcohol levels in women. 34,35,50,51 Importantly, most of these previous studies included only a few women consuming high levels of alcohol. In a recent analysis of the large UK Biobank cohort, with balanced sexes and a sufficient number of women in the high level of alcohol consumption group, associations of alcohol and arrhythmias in both men and women were reported.…”

Section: Beverage-specific Relationship Between Alcohol and Afmentioning

confidence: 99%

Mechanisms and Therapeutic Opportunities in Atrial Fibrillation in Relationship to Alcohol Use and Abuse

Linz

Hertel

Jespersen

et al. 2022

Canadian Journal of Cardiology

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Alcohol consumption and risk of incident atrial fibrillation: A population-based cohort study

Cited by 19 publications

References 38 publications

Alcohol consumption and atrial fibrillation risk: An updated dose-response meta-analysis of over 10 million participants

Alcohol consumption and atrial fibrillation risk: An updated dose-response meta-analysis of over 10 million participants

The role of alcohol consumption on echocardiographic and electrophysiologic changes in atrial fibrillation

Mechanisms and Therapeutic Opportunities in Atrial Fibrillation in Relationship to Alcohol Use and Abuse

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