Alcohol consumption and persistent infection of high-risk human papillomavirus

Abstract

Alcohol consumption is a possible co-factor of high-risk human papillomavirus (HR-HPV) persistence, a major step in cervical carcinogenesis, but the association between alcohol and continuous HPV infection remains unclear. This prospective study identified the association between alcohol consumption and HR-HPV persistence. Overall, 9230 women who underwent screening during 2002-2011 at the National Cancer Center, Korea were analysed in multivariate logistic regression. Current drinkers [odds ratio (OR) 2·49, 95% confidence interval (CI) 1·32-4·71] and drinkers for ⩾5 years (OR 2·33, 95% CI 1·17-4·63) had a higher risk of 2-year HR-HPV persistence (HPV positivity for 3 consecutive years) than non-drinkers and drinkers for <5 years, respectively (vs. HPV negativity for 3 consecutive years). A high drinking frequency (⩾twice/week) and a high beer intake (⩾3 glasses/occasion) had higher risks of 1-year (OR 1·80, 95% CI 1·01-3·36) HPV positivity for 2 consecutive years) and 2-year HR-HPV persistence (OR 3·62, 95% CI 1·35-9·75) than non-drinkers. Of the HPV-positive subjects enrolled, drinking habit (OR 2·68, 95% CI 1·10-6·51) and high consumption of beer or soju (⩾2 glasses/occasion; OR 2·90, 95% CI 1·06-7·98) increased the risk of 2-year consecutive or alternate HR-HPV positivity (vs. consecutive HPV negativity). These findings suggest that alcohol consumption might increase the risk of cervical HR-HPV persistence in Korean women.

Socioeconomic and lifestyle factors associated with HPV infection in pregnant women: a matched case-control study in Beijing, China

“…The percent of women consuming alcohol during pregnancy has been reported as a serious problem in other countries, such as 32.5% in Congo [ 31 ], 4.4% in India [ 32 ]. A study in Korea [ 33 ] suggests that women who drink alcohol may have an increased risk of persistent HPV. They tested 9230 women for HPV and found that current drinkers were nearly three times more likely than non-drinkers to test positive for HPV at the beginning of the study, and then again at a 2-year follow-up.…”

Awareness and knowledge regarding of cervical cancer, Pap smear screening and human papillomavirus infection in Gabonese women

“…High parity, early age at first pregnancy, heredity, excessive sex and alcohol/drug were less frequently cited by the women. High parity and early age at first pregnancy have been described in the literature as risk factors for cervical cancer [ 17 , 19 ]; however, the role of heredity and alcohol/drug use remains unclear [ 17 , 20 ]. A high proportion of women (62.3%) reported that they were moderately/extremely worried about having/developing cervical cancer.…”

Alcoholic Beverage Consumption and Chronic Diseases

“…High-risk Human Papillomavirus (HR-HPV) persistence has been confirmed as a major step in cervical carcinogenesis. Prospective studies showed that alcohol consumption was associated with increased risks of cervical HR-HPV persistence [ 48 , 49 ]. Alcohol drinkers also showed higher risks of cervical intraepithelial neoplasia (CIN) 1 compared with abstainers, and high drinking frequency and quantity would even aggravate the issue [ 50 ].…”