Alcohol consumption and its relation to risk factors for cardiovascular disease in the north-west of Russia: the Arkhangelsk study

Nilssen, Odd; Averina, Maria; Brenn, Tormod; Brox, Jan; Kalinin, Alexei; Archipovski, Vadim

doi:10.1093/ije/dyi078

Cited by 56 publications

(52 citation statements)

References 31 publications

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“…A very recent study from the northwest region of Russia revealed GGT levels in both sexes that were more than twice as high as those found in comparable studies. 34 This study offers further evidence that elevated GGT is significantly associated with increased risk for CVD.…”

Section: Discussionsupporting

confidence: 54%

γ-Glutamyltransferase as a Risk Factor for Cardiovascular Disease Mortality

et al. 2005

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the Vorarlberg Health Monitoring and Promotion Program Study GroupBackground-There is evidence from recent studies that ␥-glutamyltransferase (GGT) is likely to be associated with cardiovascular disease (CVD). However, few studies to date with sufficient sample size and follow-up investigated the association of GGT with CVD mortality. Methods and Results-The relation of GGT to the risk of death from CVD was examined in a cohort of 163 944 Austrian adults that was monitored for up to 17 years. To evaluate GGT as an independent predictor, Cox proportional hazards models were calculated, which adjusted for established risk factors. In both men and women, high GGT was significantly (PϽ0.001) associated with total mortality from CVD, showing a clear dose-response relationship. Adjusted hazard ratios (95% CI) per log GGT increase were 1.66 (1.40 to 1.98) in men and 1.64 (1.36 to 1.97) in women. In men, subgroup analyses showed that high GGT was positively associated with incident fatal events of chronic forms of coronary heart disease (Pϭ0.009), congestive heart failure (PϽ0.001), and hemorrhagic (Pϭ0.01) and ischemic stroke (PϽ0.001). No significant associations were observed for acute myocardial infarction (Pϭ0.16). In women, hazard ratios suggested associations in all subgroups; however, for hemorrhagic and ischemic stroke they were not statistically significant (Pϭ0.09 and Pϭ0.07, respectively). In addition, subgroup analyses stratified by age revealed a stronger relationship of GGT in younger participants. Hazard ratios for total CVD were 2.

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Section: Discussionsupporting

confidence: 54%

γ-Glutamyltransferase as a Risk Factor for Cardiovascular Disease Mortality

et al. 2005

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“…The harmful drinking might be responsible for these gender differences. The population surveys from Russia show consistently higher rates of binge drinking among men than women [17,18].…”

Section: Discussionmentioning

confidence: 97%

Fatal Alcohol Poisonings and Traffic Accidents in Russia

Разводовский

2016

Alcoholism Psychiatry Res

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-Russia has one of the world's highest road traffic fatality rates. There is common believe that high level of alcohol consumption in conjunction with binge drinking pattern is a major determinant of high traffic accidents mortality rates in this country. Objective: The aim of the present study was to estimate the aggregate level effect of binge drinking on the traffic accidents mortality rates in Russia. Method: Age-standardized sex-specific male and female fatal alcohol poisonings (as a proxy for binge drinking) and traffic accidents mortality data for the period 1970-2013 were analyzed by means time series analysis. The results of the analysis indicate the presence of a statistically significant association between the two time series for males and for females. Conclusions: The outcomes of this study provide support for the hypothesis that binge drinking is an important contributor to the traffic accidents mortality rates in Russian Federation. The findings from the present study have important implications as regards traffic accidents mortality prevention indicating that a restrictive alcohol policy can be considered as an effective measure of prevention in countries where higher rate of alcohol consumption conjunct with binge drinking pattern.

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“…The population surveys from Russia show consistently higher rates of binge drinking among men than women. Indeed, the results of study carried out in Archangelsk suggest that 61.9% of male and 25.7% of female industrial workers had a consumption pattern that was hazardous according to the AUDIT definition (Nilssen et al, 2005).…”

Section: Discussionmentioning

confidence: 99%

Estimación de la fracción de la mortalidad en Rusia atribuible al alcohol

Razvodovsky

2012

Adicciones

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Accumulated research evidence suggests that alcohol is a major contributor to premature deaths toll in Russia. The aim of the present study was to estimate the premature adult mortality attributable to alcohol abuse in Russia on the basis of aggregate-level data of allcause mortality and alcohol consumption. With this purpose agestandardized sex-specific male and female all-cause mortality data for the period 1980-2005 and data on overall alcohol consumption were analyzed by means ARIMA time series analysis. As a result alcohol consumption was significantly associated with both male and female all-cause mortality rates: a 1 liter increase in overall alcohol consumption would result in a 3.9% increase in the male mortality rate and in 2.4% increase in female mortality rate. The results of the analysis also suggest that 41.1% of all male deaths and 27.8% female deaths in Russia could be attributed to alcohol. We can conclude that alcohol is a major contributor to the high mortality rate in Russian Federation. Therefore prevention of alcohol-attributable harm should be a major public health priority in Russia.Key words: mortality, alcohol drinking, alcohol attributable fraction, Russia.La evidencia acumulada sugiere que el alcohol contribuye de forma importante a la cifra total de muertes prematuras en Rusia. El objetivo del presente estudio fue estimar la mortalidad adulta prematura atribuible al abuso de alcohol en Rusia sobre la base de datos a nivel agregado de todas las causas de mortalidad y de consumo de alcohol. Con este propósito se analizaron los datos de mortalidad por cualquier causa para el período 1980-2005 estandarizados por edad y por sexo junto con los datos sobre el consumo global de alcohol mediante series temporales ARIMA. Como resultado de la comparación, se encontró que el consumo de alcohol se asociaba significativamente con todas las causas de mortalidad masculina y femenina: un aumento de 1 litro en el consumo global de alcohol se traduciría en un aumento del 3,9% en la tasa de mortalidad masculina y en un 2,4% de aumento en la tasa de mortalidad femenina. Los resultados del análisis también indican que el 41,1% de las defunciones de hombres y el 27,8% las muertes de mujeres en Rusia podría atribuirse al alcohol. Podemos concluir que el alcohol es un importante contribuyente a la alta tasa de mortalidad en la Federación de Rusia. Por lo tanto la prevención de daños atribuibles al alcohol debe ser una prioridad de salud pública en Rusia.Palabras clave: mortalidad, consumo de alcohol, Rusia. Estimación de la fracción de la mortalidad en Rusia atribuible al alcohol

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Alcohol consumption and its relation to risk factors for cardiovascular disease in the north-west of Russia: the Arkhangelsk study

Abstract: Background To explore indicators and levels of alcohol consumption in a Russian population, and to elaborate these in relation to risk factors for cardiovascular disease.

Cited by 56 publications

References 31 publications

γ-Glutamyltransferase as a Risk Factor for Cardiovascular Disease Mortality

γ-Glutamyltransferase as a Risk Factor for Cardiovascular Disease Mortality

Fatal Alcohol Poisonings and Traffic Accidents in Russia

Estimación de la fracción de la mortalidad en Rusia atribuible al alcohol

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