Alcohol consumption and insulin resistance syndrome parameters: associations and evolutions in a longitudinal analysis of the French DESIR cohort

Vernay, Michel; Balkau, Beverley; Moreau, Jean-Guy; Sigalas, J; Chesnier, Marie-Claude; Ducimetière, Pierre

doi:10.1016/s1047-2797(03)00131-5

Cited by 30 publications

(16 citation statements)

References 31 publications

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“…The longitudinal analyses showed a positive association for both genders. Our findings are supported by the French DESIR (Vernay et al, 2004) and the Copenhagen City Heart Study (Vadstrup et al, 2003). In women, this is additionally shown by two other studies (Kahn et al, 1997;Halkjaer et al, 2006).…”

Section: Discussionsupporting

confidence: 88%

“…This belief might have found support by cross-sectional research, reporting abdominal obesity as being associated with beer consumption (Slattery et al, 1992;Duncan et al, 1995;Dallongeville et al, 1998;Bobak et al, 2003;Wannamethee et al, 2005). In contrast, prospective studies have been rather inconsistent, reporting positive associations (Vadstrup et al, 2003;Vernay et al, 2004), no associations (Halkjaer et al, 2004;Koppes et al, 2005) or even marginally negative associations among men (Halkjaer et al, 2006).…”

Section: Introductionmentioning

confidence: 99%

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Beer consumption and the ‘beer belly’: scientific basis or common belief?

et al. 2009

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Background/Objectives: The term 'beer belly' expresses the common belief that beer consumption is a major determinant of waist circumference (WC). We studied the gender-specific associations between beer consumption and WC (partially in relation to body weight and hip circumference (HC) change). Participants/Methods: Within the European Prospective Investigation into Cancer and Nutrition (EPIC)-Potsdam study (7876 men, 12 749 women), cross-sectional associations were investigated applying general linear models. Prospective analyses of baseline beer consumption and an 8.5-year WC change were assessed using multivariate general linear models and polytomous logistic regression. To test the site-specific effect of beer consumption on WC, an adjustment for concurrent changes in body weight and HC was carried out. In addition, the relationship between change in beer consumption and change in WC was studied. Results: A positive association in men and no association in women were seen between beer consumption and WC at baseline. Men consuming 1000 ml/d beer were at 17% higher risk for WC gain compared with very light consumers. Significantly lower odds for WC gain (odds ratio ¼ 0.88; 95% confidence interval 0.81, 0.96) were found in beer-abstaining women than in verylight-drinking women. The adjustment for concurrent body weight and HC change diminished effect estimates notably, explaining most of the association between beer and change in WC. Decreasing beer consumption was related to higher relative odds for WC loss, although not statistically significant. Conclusions: Beer consumption leads to WC gain, which is closely related to concurrent overall weight gain. This study does not support the common belief of a site-specific effect of beer on the abdomen, the beer belly.

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Section: Discussionsupporting

confidence: 88%

Section: Introductionmentioning

confidence: 99%

Beer consumption and the ‘beer belly’: scientific basis or common belief?

et al. 2009

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“…Positive associations between the use of alcohol and abdominal adiposity have consistently been reported for men and frequently for women in cross-sectional (Marti et al, 1991;Troisi et al, 1991;Slattery et al, 1992;Randrianjohany et al, 1993;Dallongeville et al, 1998;Han et al, 1998) or prospective studies (Grinker et al, 1995;Vadstrup et al, 2003;Vernay et al, 2004). Studies showing different results focused on the role of alcohol for the change of anthropometric measures (Koh-Banerjee et al, 2003;Halkjaer et al, 2004Halkjaer et al, , 2006.…”

Section: Discussionmentioning

confidence: 99%

The association of lifetime alcohol use with measures of abdominal and general adiposity in a large-scale European cohort

et al. 2011

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Background/Objectives: The relation between lifetime use of alcohol and measures of abdominal and general adiposity is unknown. Subjects/Methods: Among 99 381 men and 158 796 women of the European Prospective Investigation into Cancer and Nutrition (EPIC) study, means of waist circumference (WC), waist-to-hip-ratio (WHR) and body mass index (BMI), and odds ratios (OR) for a larger WC than predicted for a given BMI (WClp ¼ positive residuals of gender specific linear regression of BMI on WC) across categories of average lifetime use of alcohol (total, from wine and from beer) were calculated, all adjusted for socio-demographic, lifestyle and health factors. 1.32, 1.49) in men using 460 g/d and 1.63 (1.54, 1.73) in women using 424 g/d), though increase was higher for alcohol from beer than from wine (P for difference between beer and wineo0.001 (men) and ¼ 0.002 (women)). Conclusion: Lifetime alcohol use is positively related to abdominal and general adiposity in men, possibly following the male weight gain pattern; in women, it is positively related only to abdominal adiposity. In this context, beer may contribute additionally to abdominal adiposity.

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“…Nonetheless, the relationship between alcohol intake and insulin sensitivity has been controversial for the last several decades. Although light to moderate alcohol intake may reduce cerebrovascular risk via increased high density lipoprotein-cholesterol (HDL-C) and insulin sensitivity, chronic heavy alcohol intake is closely correlated with onset of insulin resistance syndrome (Vernay et al 2004). When cells fail to receive sufficient trophic input from insulin or insulin-like growth factors under insulin resistant state, oxidative injury and apoptosis occur (Connor and Dragunow 1998;Ebadi et al 1997).…”

Section: Introductionmentioning

confidence: 99%

Chronic alcohol consumption alters mammalian target of rapamycin (mTOR), reduces ribosomal p70s6 kinase and p4E-BP1 levels in mouse cerebral cortex

Ren

2007

Experimental Neurology

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Reduced insulin sensitivity following chronic alcohol consumption may contribute to alcoholinduced brain damage although the underlying mechanism(s) has not been elucidated. This study was designed to examine the effect of chronic alcohol intake on insulin signaling in mouse cerebral cortex. FVB mice were fed with a 4% alcohol diet for 16 weeks. Insulin receptor substrates (IRS-1, IRS-2) and post-receptor signaling molecules Akt, mammalian target of rapamycin (mTOR), ribosomal p70s6 kinase (p70s6k) and the eukaryotic translation initiation factor 4E (eIF4E)-binding protein 1 (4E-BP1) as well as the apoptotic marker caspase-3 were evaluated using Western blot analysis. Chronic alcohol intake significantly dampened whole body glucose tolerance, enhanced expression of caspase-3 and mTOR, reduced p70s6k and 4E-BP1 with little effect on Akt signaling in alcohol consuming mice. These data suggest that chronic alcohol intake may contribute to cerebral cortex dysfunction through mechanisms related, at least in part, to dampened post insulin receptor signaling at the levels of mTOR, p70s6k and 4E-BP1.

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Alcohol consumption and insulin resistance syndrome parameters: associations and evolutions in a longitudinal analysis of the French DESIR cohort

Cited by 30 publications

References 31 publications

Beer consumption and the ‘beer belly’: scientific basis or common belief?

Beer consumption and the ‘beer belly’: scientific basis or common belief?

The association of lifetime alcohol use with measures of abdominal and general adiposity in a large-scale European cohort

Chronic alcohol consumption alters mammalian target of rapamycin (mTOR), reduces ribosomal p70s6 kinase and p4E-BP1 levels in mouse cerebral cortex

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