Alcohol Consumption and Incident Cataract Surgery in Two Large UK Cohorts

Syl., Chua; Luben, Robert; Hayat, Shabina; Broadway, David C; Khaw, Kay‐Tee; Warwick, Alasdair; Britten, Abigail; Strouthidis, Nicholas G.; Patel, Praveen J; Khaw, Peng Tee; Foster, Paul J.; Khawaja, Anthony P; Eye, UK Biobank

doi:10.1016/j.ophtha.2021.02.007

Cited by 23 publications

(28 citation statements)

References 43 publications

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“…In a cohort of 34,713 Swedish women, the risk of senile cataract started to increase at a daily use of ≥ 1 alcoholic drinks 10 . However, a recent study with data from two large cohorts implied that low-to-moderate alcohol consumption might lower the risk of undergoing cataract surgery 39 , which is in line with a meta-analysis including observational studies published before May 2014 11 . In another meta-analysis based on 7 prospective cohort studies, the pattern of association between alcohol consumption and senile cataract risk was unclear 12 .…”

Section: Discussionsupporting

confidence: 69%

Metabolic and lifestyle factors in relation to senile cataract: a Mendelian randomization study

Yuan

Wolk

Larsson

2022

Sci Rep

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We conducted a Mendelian randomization study to determine the associations of body mass index (BMI), type 2 diabetes (T2D), systolic blood pressure (SBP), coffee and alcohol consumption and smoking initiation with senile cataract. Independent single nucleotide polymorphisms associated with the metabolic and lifestyle factors at the p < 5 × 10–8 were selected as instrument variables. Summary-level data for senile cataract were obtained from the FinnGen consortium (20,157 cases and 154,905 non-cases) and UK Biobank study (6332 cases and 354,862 non-cases). Higher genetically predicted BMI and SBP and genetic predisposition to T2D and smoking initiation were associated with an increased risk of senile cataract. The combined odds ratios were 1.19 (95% confidence interval (CI) 1.09–1.29; p < 0.001) per one standard deviation increase in BMI (~ 4.8 kg/m2), 1.13 (95% CI 1.04–1.23; p = 0.004) per 10 mmHg increase in SBP, 1.06 (95% CI 1.03–1.09; p < 0.001) per one unit increase in log-transformed odds ratio of T2D, and 1.19 (95% CI 1.10–1.29; p < 0.001) per one standard deviation increase in prevalence of smoking initiation. Genetically predicted coffee consumption showed a suggestive association with senile cataract (odds ratio per 50% increase, 1.18, 95% CI 1.00–1.40; p = 0.050). This study suggests causal roles of obesity, T2D, SBP and smoking in senile cataract.

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Section: Discussionsupporting

confidence: 69%

Metabolic and lifestyle factors in relation to senile cataract: a Mendelian randomization study

Yuan

Wolk

Larsson

2022

Sci Rep

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“…The most striking and interesting finding for COVID-19 infection was the recommended intake of different alcoholic beverages. The protective association of low-to-moderate alcohol consumption with a lower risk of cataracts (17), a lower risk of myocardial infarction (6), and a better cognitive function (18) have been reported. In our study, the consumption of different alcoholic beverages was associated with different chances of COVID-19 infection.…”

Section: Discussionmentioning

confidence: 97%

COVID-19 Risk Appears to Vary Across Different Alcoholic Beverages

et al. 2022

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Objectives: To evaluate the associations of status, amount, and frequency of alcohol consumption across different alcoholic beverages with coronavirus disease 2019 (COVID-19) risk and associated mortality.Methods: This study included 473,957 subjects, 16,559 of whom tested positive for COVID-19. Multivariate logistic regression analyses were used to evaluate the associations of alcohol consumption with COVID-19 risk and associated mortality. The non-linearity association between the amount of alcohol consumption and COVID-19 risk was evaluated by a generalized additive model.Results: Subjects who consumed alcohol double above the guidelines had a higher risk of COVID-19 (1.12 [1.00, 1.25]). Consumption of red wine above or double above the guidelines played protective effects against the COVID-19. Consumption of beer and cider increased the COVID-19 risk, regardless of the frequency and amount of alcohol intake. Low-frequency of consumption of fortified wine (1–2 glasses/week) within guidelines had a protective effect against the COVID-19. High frequency of consumption of spirits (≥5 glasses/week) within guidelines increased the COVID-19 risk, whereas the high frequency of consumption of white wine and champagne above the guidelines decreased the COVID-19 risk. The generalized additive model showed an increased risk of COVID-19 with a greater number of alcohol consumption. Alcohol drinker status, frequency, amount, and subtypes of alcoholic beverages were not associated with COVID-19 associated mortality.Conclusions: The COVID-19 risk appears to vary across different alcoholic beverage subtypes, frequency, and amount. Red wine, white wine, and champagne have chances to reduce the risk of COVID-19. Consumption of beer and cider and spirits and heavy drinking are not recommended during the epidemics. Public health guidance should focus on reducing the risk of COVID-19 by advocating healthy lifestyle habits and preferential policies among consumers of beer and cider and spirits.

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“…20 Furthermore, we used surgical procedures (OPCS4) to identify cataract events (codes: C71.2 or C75.1). 21 Types of cataract including cortical and nuclear cataract were also analyzed. The earliest recorded code date was used as the onset date of cataract.…”

Section: Methodsmentioning

confidence: 99%