Alcohol consumption—A risk factor for hemorrhagic and non-hemorrhagic stroke

Gill, Jaswinder; Shipley, Martin J.; Tsementzis, S A; Hornby, Robbie S.; Gill, S K; Hitchcock, Edward; Beevers, D. G.

doi:10.1016/0002-9343(91)90610-a

Cited by 131 publications

(47 citation statements)

References 34 publications

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“…103 Stroke. A meta-analysis 57 and a Finnish case-control study 104,105 suggest that more than 4 drinks daily on average increases the risk of stroke. Other Finnish studies have also suggested that acute intoxication might be associated with ischemic stroke in women, especially young women.…”

Section: Medical Risks Of Drinking For Women Compared With Menmentioning

confidence: 99%

Medical risks for women who drink alcohol

et al. 1998

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OBJECTIVE:To summarize for clinicians recent epidemiologic evidence regarding medical risks of alcohol use for women.METHODS: MEDLINE and PsychINFO, 1990 through 1996, were searched using key words "women" or "woman," and "alcohol." MEDLINE was also searched for other specific topics and authors from 1980 through 1996. Data were extracted and reviewed regarding levels of alcohol consumption associated with mortality, cardiovascular disease, alcoholrelated liver disease, injury, osteoporosis, neurologic symptoms, psychiatric comorbidity, fetal alcohol syndrome, spontaneous abortion, infertility, menstrual symptoms, breast cancer, and gynecologic malignancies. Gender-specific data from cohort studies of general population or large clinical samples are primarily reviewed. MAIN RESULTS:Women develop many alcohol-related medical problems at lower levels of consumption than men, probably reflecting women's lower total body water, gender differences in alcohol metabolism, and effects of alcohol on postmenopausal estrogen levels. Mortality and breast cancer are increased in women who report drinking more than two drinks daily. Higher levels of alcohol consumption by women are associated with increased menstrual symptoms, hypertension, and stroke. Women who drink heavily also appear to have increased infertility and spontaneous abortion. Adverse fetal effects occur after variable amounts of alcohol consumption, making any alcohol use during pregnancy potentially harmful. CONCLUSIONS:In general, advising nonpregnant women who drink alcohol to have fewer than two drinks daily is strongly supported by the epidemiologic literature, although specific recommendations for a particular woman should depend on her medical history and risk factors. L ess than three quarters of women in the UnitedStates drink alcohol, and those who do drink consume fewer drinks and less absolute alcohol than men. 1 However, at similar levels of self-reported alcohol consumption, the risk of psychosocial problems or dependence is greater for women than men (for definitions, see Appendix A). [2][3][4][5][6] Women also appear to develop alcohol abuse and dependence after fewer years of drinking than men. 7 Although only 4% to 5% of women in the U.S. general population meet criteria for past-year alcohol abuse or dependence, 8,9 9% of female primary care patients in some studies have reported recent heavy drinking or alcohol-related problems. 10,11 Many heavy drinkers decrease consumption following brief interventions that include explicit advice about safe drinking limits. [12][13][14] In addition, offering feedback about specific risks or consequences of their drinking to patients who drink heavily can help motivate them to decrease alcohol consumption or seek treatment. 15,16 Physicians report they would be more likely to advise patients about safe drinking practices if they were more confident of their knowledge about safe levels of alcohol consumption. 17 Women who drink more than two drinks daily on average, or who frequently drink five or more d...

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Section: Medical Risks Of Drinking For Women Compared With Menmentioning

confidence: 99%

Medical risks for women who drink alcohol

et al. 1998

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“…T he large number of cohort studies showed an increased risk of hemorrhagic stroke among male heavy drinkers, [1][2][3][4][5][6][7][8][9][10] and reduced risk of ischemic stroke 9 -11 and coronary heart disease [12][13][14][15][16][17] among male light-to-moderate drinkers.…”

mentioning

confidence: 99%

Alcohol Consumption and Mortality From Stroke and Coronary Heart Disease Among Japanese Men and Women

Ikehara

Iso

Toyoshima

et al. 2008

Stroke

113

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Background and Purpose-Previous studies have demonstrated the association between alcohol consumption and cardiovascular mortality. However, the sex-specific association between alcohol consumption and mortality from stroke and coronary heart disease remains unclear. Methods-Between 1988 and 1990, 34 776 men and 48 906 women aged 40 to 79 years completed a self-administered questionnaire including information about alcohol consumption. They were followed-up for a median duration of 14.2 years. Results-Of the 83 682 respondents, 1628 died from stroke and 736 died from coronary heart disease. For men, heavy drinking (Ն46.0 g ethanol/day) was associated with increased mortality from total, hemorrhagic, and ischemic strokes, whereas light-to-moderate drinking was associated with reduced mortality from total cardiovascular disease, compared with not drinking. The respective multivariable hazard ratios (95% CI) were 1.48 (1.22 to 1.80) for total stoke, 1.67 (1.17 to 2.38) for hemorrhagic stroke, 1.35 (1.04 to 1.75) for ischemic stroke, and 0.88 (0.78 to 1.00) for total cardiovascular disease. Women who were heavy drinkers (Ն46.0 g ethanol/day) showed increased mortality from coronary heart disease, and there was reduced mortality from total cardiovascular disease for drinkers of 0.1 to 22.9 g ethanol per day compared with mortality for nondrinkers. The respective multivariable hazard ratios (95% CI) for the 2 categories of drinkers were 4.10 (1.63 to 10.3) and 0.75 (0.62 to 0.91). Conclusions-Heavy alcohol consumption is associated with increased mortality from total stroke, particularly hemorrhagic stroke, and total cardiovascular disease for men, and from coronary heart disease for women, whereas light-to-moderate drinking may be associated with reduced mortality from cardiovascular disease for both sexes.

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“…ALDH-E2 involves in the oxidative pathway of alcohol metabolism (Smith, 1986;Hempel et al, 1987). Substantial evidence indicated that alcohol abuse is sever risk factor for stroke (Gill et al, 1986(Gill et al, , 1991Hillbom et al, 1999;Klatsky et al, 2001;Mazzaglia et al, 2001). ALDH2 polymorphisms play a pivotal role on hypertension (Hasi et al, 2011;Wang et al, 2013;Yokoyama et al, 2013;Hu et al, 2014), heart disease (Gu, Li, 2014;Mizuno et al, 2015) and stroke (Yao et al, 2011;Lai et al, 2012).…”

Section: Discussionmentioning

confidence: 99%

Genetic polymorphisms and related risk factors of ischemic stroke in a Mongolian population in China

Wu¹,

Wu²,

Orlov³

et al. 2017

Vestn. VOGiS

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Ишемический инсульт, вызванный прерыванием потока крови в мозг, представляет серьезную медицинскую проблему, являясь фактором риска смерти и потери трудоспособности. Недавние исследования геномных ассоциаций (genome-wide association studies -GWAS) определили более 40 общих вари-антов геномных последовательностей, связанных с ишемиче-ским инсультом. Однако результаты не могут быть одинаково применимы для различных мировых популяций. В данной ра-боте мы рассматриваем гипотезу о том, что население Север-ной Азии, живущее в суровых условиях окружающей среды, может иметь уникальный спектр генов риска развития заболе-ваний сердечно-сосудистой системы. Исследованы гены-кан-дидаты предрасположенности к ишемическому инсульту в по -пуляции монголов Китая, которая не была изучена ранее. В ис-следование были включены в общей сложности 167 больных с инсультом и 176 здоровых лиц. Генотипирование выполне-но с помощью секвенирования ампликонов. Обнаружена ассоциация развития ишемического инсульта с одиночными нуклеотидными полиморфизмами в генах NINJ2 (rs12425791) и ALDH2 (rs2238151), а также в межгенном участке rs9536591. Среди генов-кандидатов наибольший вклад в развитие ин-сульта вносит NINJ2 (rs12425791). Ген ALDH2 кодирует митохон-дриальный фермент альдегиддегидрогеназу, вовлеченную в оксида тивный путь метаболизма алкоголя. Пол, возраст, индекс массы тела и высокое кровяное давление также могут быть факто рами риска. Данная работа показала существующую гетеро генность между китайской и другими популяционными выбор ками. Наше исследование предлагает новый взгляд на взаимо действие генотипа и факторов окружающей среды при развитии ишемического инсульта в монгольском населении.Ключевые слова: популяционная генетика; геном человека; однонуклеотидные замены; монгольская популяция Китая; ишемический инсульт. Ischemic stroke is caused by an interruption in the flow of blood to the brain and a risk factor for death and disability. Recent genome-wide association studies have identified more than 40 common sequence variants associated with ischemic stroke. however, the results are not always the same in populations with different genetic backgrounds. In the present study, we evaluated a hypothesis that a North Asian population living in a geographic area with unusually harsh environmental conditions would develop unique genetic risks. We investigated the candidate genes for ischemic stroke and risk factors in a Chinese Mongolian population which has not been explored previously. A total of 167 stroke cases and 176 controls were included in the study. Genotyping was performed by amplicon sequencing. The association was detected with single nucleotide polymorphisms (SNPs) located within genes NINJ2 (rs12425791) and ALDH2 (rs2238151) as well as intergenic rs9536591 were significantly associated with ischemic stroke, of which SNP rs12425791 of the NINJ2 gene was the strongest association. ALDH2 gene encodes mitochondrial aldehyde dehydrogenase, involved in the oxidative pathway of alcohol metabolism. Sex, age, body mass index and high ...

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Alcohol consumption—A risk factor for hemorrhagic and non-hemorrhagic stroke

Cited by 131 publications

References 34 publications

Medical risks for women who drink alcohol

Medical risks for women who drink alcohol

Alcohol Consumption and Mortality From Stroke and Coronary Heart Disease Among Japanese Men and Women

Genetic polymorphisms and related risk factors of ischemic stroke in a Mongolian population in China

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