Alcohol-associated liver disease, not hepatitis B, is the major cause of cirrhosis in Asia

Singh, Shivaram Prasad; Panigrahi, Subhendu; Mishra, Debakanta

doi:10.1016/j.jhep.2019.01.003

Cited by 15 publications

(10 citation statements)

References 12 publications

(3 reference statements)

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“…The increase in ASR was higher in females than in males, similar to the result obtained by Roerecke et al [33]. Additionally, alcohol was found to play an increasingly important role in chronic liver diseases [34]. Thus, polices to reduce alcohol consumption should be implemented to improve population health, and people with high alcohol consumption should receive interventions to reduce their intake [33].…”

Section: Discussionsupporting

confidence: 79%

The burden of liver cirrhosis and underlying etiologies: results from the global burden of disease study 2017

Zhai

Long

Liu

et al. 2021

Aging

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Background: To evaluate the pattern and prevalence trends of liver cirrhosis caused by specific etiologies. Results: Globally, the number of prevalent cases increased 74.53% from 1990 to 2017. The ASR increased 0.75 per year. The most pronounced increases were found in middle-high and high socio-demographic index (SDI) regions, especially in the Caribbean and Latin America. Among the etiologies, non-alcoholic steatohepatitis (NASH) related liver cirrhosis accounted for 59.46% of the cases. The ASR increased 1.74 per year, and the increase was observed in all 5 SDI regions. In addition, the ASR of liver cirrhosis caused by alcohol also increased in both sexes and all SDI regions. In contrast, the ASR of liver cirrhosis caused by hepatitis B virus (HBV) and hepatitis C virus (HCV) decreased, especially in middle and low-middle SDI regions. Conclusions: Though the number of people suffering from HBV and HCV decreases, liver cirrhosis is still a major threat to health. Additionally, the number of people with cirrhosis caused by alcohol and NASH continues to grow. Thus, more targeted and specific strategies should be established based on etiology and prevalence trends of liver cirrhosis. Methods: We collected data based on Global Burden of Disease (GBD) 2017 study. The age standardized prevalence rate (ASR) and estimated annual percentage changes (EAPC) were used to estimate the trends in prevalence by population, etiologies and regions.

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Section: Discussionsupporting

confidence: 79%

The burden of liver cirrhosis and underlying etiologies: results from the global burden of disease study 2017

Zhai

Long

Liu

et al. 2021

Aging

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“…Clinical findings have shown that the incidence of HCC and the associated mortality rates are higher in men than in women ( Sukocheva, 2018 ). This has been attributed to the lack of a protective effect of high oestrogen levels in men who drink heavily ( Baecker et al, 2018 ; Montano-Loza et al, 2018 ; Singh et al, 2019 ). Although the pathogenesis of alcohol-induced HCC is complicated and still unclear, it is certain that alcohol toxicity causes liver cells to catabolise fatty acids, resulting in fat accumulation and fibrosis.…”

Section: Discussionmentioning

confidence: 99%

Identification of a prognostic signature of nine metabolism-related genes for hepatocellular carcinoma

Tang

Liu

et al. 2020

PeerJ

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Background Hepatocellular carcinoma (HCC) is the fifth most common cancer. Since changes in liver metabolism contribute to liver disease development, it is necessary to build a metabolism-related prognostic model for HCC. Methods We constructed a metabolism-related-gene (MRG) signature comprising nine genes, which segregated HCC patients into high- and low-risk groups. Results The survival rate (overall survival: OS; relapse-free survival; and progression-free survival) of patients in the low-risk group of The Cancer Genome Atlas (TCGA) cohort was significantly higher than that of patients in the high-risk group. The OS prognostic signature was validated in the International Cancer Genome Consortium independent cohort. The corresponding receiver operating characteristic curves of the model indicated that the signature had good diagnostic efficiency, in terms of improving OS over 1, 3, and 5 years. Hierarchical analysis demonstrated that the MRG signature was significantly associated with better prognosis in male patients, patients aged ≤ 65 years, and patients carrying the wild-type TP53 or CTNNB1 genes. A nomogram was established, and good performance and clinical practicability were confirmed. Additionally, using the GSE109211 dataset from the Gene Expression Omnibus database, we were able to verify that the nine genes in this MRG signature had different responses to sorafenib, suggesting that some of these MRGs may act as therapeutic targets for HCC. Conclusions We believe that these findings will add value in terms of the diagnosis, treatment, and prognosis of HCC.

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“…Clinical findings have shown that the incidence of HCC and the associated mortality rates are higher in men than in women (Sukocheva 2018). This has been attributed to the lack of a protective effect of high oestrogen levels in men who drink heavily (Baecker et al 2018;Montano-Loza et al 2018;Singh et al 2019). Although the pathogenesis of alcohol-induced HCC is complicated and still unclear, it is certain that alcohol toxicity causes liver cells to catabolise fatty acids, resulting in fat accumulation and fibrosis.…”

Section: Discussionmentioning

confidence: 99%

Peer Review #2 of "Identification of a prognostic signature of nine metabolism-related genes for hepatocellular carcinoma (v0.2)"

2020

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Background. Hepatocellular carcinoma (HCC) is the fifth most common cancer. Since changes in liver metabolism contribute to liver disease development, it is necessary to build a metabolism-related prognostic model for HCC. Methods. We constructed a metabolism-related-gene (MRG) signature comprising nine genes, which segregated HCC patients into high-and low-risk groups. Results. The survival rate (overall survival: OS; relapse-free survival; and progression-free survival) of patients in the low-risk group of The Cancer Genome Atlas (TCGA) cohort was significantly higher than that of patients in the high-risk group. The OS prognostic signature was validated in the International Cancer Genome Consortium independent cohort. The corresponding receiver operating characteristic curves of the model indicated that the signature had good diagnostic efficiency, in terms of improving OS over 1, 3, and 5 years. Hierarchical analysis demonstrated that the MRG signature was significantly associated with better prognosis in male patients, patients aged ≤ 65 years, and patients carrying the wild-type TP53 or CTNNB1 genes. A nomogram was established, and good performance and clinical practicability were confirmed. Additionally, using the GSE109211 dataset from the Gene Expression Omnibus database, we were able to verify that the nine genes in this MRG signature had different responses to sorafenib, suggesting that some of these MRGs may act as therapeutic targets for HCC. Conclusions. We believe that these findings will add value in terms of the diagnosis, treatment, and prognosis of HCC.

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Alcohol-associated liver disease, not hepatitis B, is the major cause of cirrhosis in Asia

Cited by 15 publications

References 12 publications

The burden of liver cirrhosis and underlying etiologies: results from the global burden of disease study 2017

The burden of liver cirrhosis and underlying etiologies: results from the global burden of disease study 2017

Identification of a prognostic signature of nine metabolism-related genes for hepatocellular carcinoma

Peer Review #2 of "Identification of a prognostic signature of nine metabolism-related genes for hepatocellular carcinoma (v0.2)"

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