Alcohol and tobacco use, and cancer risk for upper aerodigestive tract and liver

Pelucchi, Claudio; Gallus, Silvano; Garavello, Werner; Bosetti, Cristina; Vecchia, Carlo La

doi:10.1097/cej.0b013e3282f75e91

Cited by 238 publications

(185 citation statements)

References 50 publications

(73 reference statements)

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“…These studies also report that the risk becomes greater in individuals who consume alcohol and tobacco simultaneously (Inoue et al, 2007;Bagnardi et al, 2011). However, even though alcohol and tobacco are factors that act synergistically, ensuring the increased risk, alcohol is considered an independent risk factor for many types of cancer (Pelucchi et al, 2006).…”

Section: Discussionmentioning

confidence: 98%

Alcohol Consumption and Risk of Cancer: a Systematic Literature Review

Menezes¹,

Bergmann²,

Thuler³

2013

Asian Pacific Journal of Cancer Prevention

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This study aimed to discuss the consumption of alcohol as a risk factor for major cancers. We performed a search in the PubMed database, using the following inclusion criteria: meta-analysis published in English in the last 10 years that addressed the relationship between alcohol and the risk of developing cancer. The results indicate that moderate to heavy consumption of alcohol increases the risk of developing cancer of the oral cavity and pharynx, esophagus, stomach, larynx, colorectum, central nervous system, pancreas, breast and prostate. This review did not find any association between alcohol consumption and an increased risk of cancers of the lung, bladder, endometrium and ovary. It was also observed that alcohol consumption may be inversely related to thyroid cancer. Our systematic review has confirmed consumption of alcohol as a risk factor for the development of several types of cancer. Research (2007) report that there is convincing evidence linking the consumption of alcoholic beverages to cancers of the mouth, pharynx, larynx, esophagus, breast and bowel, the latter being only in men. In addition, there is a likely relationship between the consumption of alcoholic beverages and an increased risk of colon cancer and liver cancer in women.The preparation of this systemic review study is based on these considerations, with the aim of discussing the association between alcohol consumption and the main types of cancer. The expected contribution is the disclosure of consolidated information about this possible risk ratio, contributing to the establishment of strategies to prevent the occurrence of cancer. Materials and MethodsWe performed a systematic literature review of metaanalysis that was conducted to evaluate the association between alcohol consumption and cancer.The publications were identified in the PubMed bibliographic database, and used the following keywords: cancer, alcohol and meta-analysis. The first two were used as words that appeared on the title and the latter as the type of study chosen. We chose to establish a period of 10 years Raquel Ferreira de Menezes et al

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Section: Discussionmentioning

confidence: 98%

Alcohol Consumption and Risk of Cancer: a Systematic Literature Review

Menezes¹,

Bergmann²,

Thuler³

2013

Asian Pacific Journal of Cancer Prevention

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“…These heterozygotic heavy drinkers (consuming >18 alcoholic drinks/week) have greater than 80-fold increased risk for squamous cell carcinomas in the upper aerodigestive track (UADT; i.e., oral cavity and pharynx, larynx, and esophagus) compared with a ∼fourfold increase in wild-type ALDH2*1/*1 heavy drinkers (4,(13)(14)(15)(16). Further, an elevated risk of hepatocarcinoma and its recurrence occurs among hepatitis C-infected patients with the ALDH2*2 mutation (17).…”

mentioning

confidence: 99%

Pharmacological recruitment of aldehyde dehydrogenase 3A1 (ALDH3A1) to assist ALDH2 in acetaldehyde and ethanol metabolism in vivo

Chen

Cruz

Mochly‐Rosen

2015

Proc. Natl. Acad. Sci. U.S.A.

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Correcting a genetic mutation that leads to a loss of function has been a challenge. One such mutation is in aldehyde dehydrogenase 2 (ALDH2), denoted ALDH2*2. This mutation is present in ∼0.6 billion East Asians and results in accumulation of toxic acetaldehyde after consumption of ethanol. To temporarily increase metabolism of acetaldehyde in vivo, we describe an approach in which a pharmacologic agent recruited another ALDH to metabolize acetaldehyde. We focused on ALDH3A1, which is enriched in the upper aerodigestive track, and identified Alda-89 as a small molecule that enables ALDH3A1 to metabolize acetaldehyde. When given together with the ALDH2-specific activator, Alda-1, Alda-89 reduced acetaldehyde-induced behavioral impairment by causing a rapid reduction in blood ethanol and acetaldehyde levels after acute ethanol intoxication in both wild-type and ALDH2-deficient, ALDH2*1/*2, heterozygotic knock-in mice. The use of a pharmacologic agent to recruit an enzyme to metabolize a substrate that it usually does not metabolize may represent a novel means to temporarily increase elimination of toxic agents in vivo.

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“…La edad de inicio ha sido un importante factor de predicción del consumo y de las consecuencias negativas (13,39); aquí se estableció que el tiempo que transcurre entre el inicio y la primera embriaguez también lo es.…”

Section: Variables Asociadas Al Tipo De Consumounclassified

Tipología de los consumidores de alcohol y sus factores determinantes en Bucaramanga, Colombia

Herrán¹,

Ardila²

2009

biomedica

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Alcohol and tobacco use, and cancer risk for upper aerodigestive tract and liver

Cited by 238 publications

References 50 publications

Alcohol Consumption and Risk of Cancer: a Systematic Literature Review

Alcohol Consumption and Risk of Cancer: a Systematic Literature Review

Pharmacological recruitment of aldehyde dehydrogenase 3A1 (ALDH3A1) to assist ALDH2 in acetaldehyde and ethanol metabolism in vivo

Tipología de los consumidores de alcohol y sus factores determinantes en Bucaramanga, Colombia

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