Alcohol and the global burden of disease

Abat, Cédric; Roussel, Yanis; Chaudet, Hervé; Raoult, Didier

doi:10.1016/s0140-6736(19)30713-5

Cited by 10 publications

(13 citation statements)

References 5 publications

(12 reference statements)

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“…Alcohol misuse and abuse is a leading cause of morbidity and mortality ( 1 ). In 2016, global statistics suggested that 5.1% (~3 million) of deaths and 5.3% (~133 million) of disability-adjusted life years were caused by the harmful use of alcohol ( 2 ).…”

Section: Introductionmentioning

confidence: 99%

Assessing the impact of alcohol consumption on the genetic contribution to mean corpuscular volume

Thompson

King

Morris

et al. 2021

Human Molecular Genetics

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The relationship between the genetic loci that influence mean corpuscular volume (MCV) and those associated with excess alcohol drinking are unknown. We used white British participants from the UK Biobank (n = 362 595) to assess the association between alcohol consumption and MCV, and whether this was modulated by genetic factors. Multivariable regression was applied to identify predictors of MCV. GWAS, with and without stratification for alcohol consumption, determined how genetic variants influence MCV. SNPs in ADH1B, ADH1C and ALDH1B were used to construct a genetic score to test the assumption that acetaldehyde formation is an important determinant of MCV. Additional investigations using mendelian randomisation and phenomewide association analysis were conducted. Increasing alcohol consumption by 40 g/week resulted in a 0.30% (95% CI: 0.30 to 0.31%) increase in MCV (P < 1.0x10−320). Unstratified (irrespective of alcohol intake) GWAS identified 212 loci associated with MCV, of which 108 were novel. There was no heterogeneity of allelic effects by drinking status. No association was found between MCV and the genetic score generated from alcohol metabolising genes. Mendelian randomisation demonstrated a causal effect for alcohol on MCV. Seventy-one SNP-outcome pairs reached statistical significance in phenomewide association analysis, with evidence of shared genetic architecture for MCV and thyroid dysfunction, and mineral metabolism disorders. MCV increases linearly with alcohol intake in a causal manner. Many genetic loci influence MCV, with new loci identified in this analysis that provide novel biological insights. However, there was no interaction between alcohol consumption and the allelic variants associated with MCV.

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Section: Introductionmentioning

confidence: 99%

Assessing the impact of alcohol consumption on the genetic contribution to mean corpuscular volume

Thompson

King

Morris

et al. 2021

Human Molecular Genetics

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“…In addition, this study found a signi cantly lower adjPR of heart disease for those with only drinking behavior among men in the US. Abat et al have recently demonstrated that alcohol consumption levels were associated with aging [31]. The relationships between alcohol drinking and heart disease was dependent on the amount to be consumed in daily life, and the light to moderate alcohol consumption was safe and would be bene cial to the cardiovascular system [32,33].…”

Section: Discussionmentioning

confidence: 99%

“…Thus, the estimated impacts of drinking might be misleading due to the unaccounted consumption amounts and frequency of drinking in this study. Therefore, it would be safe to recommend that aligns with previous studies to keep a light to moderate alcohol intake among the current drinkers and to continue no drinking for non-drinkers for the health improvement and heart disease prevention [31,33,36].…”

Section: Discussionmentioning

confidence: 99%

Gender Disparities of Heart Disease and the Association with Smoking and Alcohol Drinking Behavior Among the Middle-Aged and Older Population in the US and China, a Cross-Sectional Study of CHARLS and HRS Data

Li¹,

Lu²,

Hurwitz³

et al. 2021

Preprint

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Background Heart disease remains the leading cause of death globally with substantial variabilities in mortalities by gender and region. Smoking and alcohol drinking are known modifiable health behaviors associated with heart disease. This study aims to estimate the prevalence of heart disease and to examine the association with smoking and drinking behavior for men and women in the United States (US) and China. Methods This study utilized the Harmonized data from the US Health and Retirement Study (HRS) and the China Health and Retirement Longitudinal Study (CHARLS), which are sister surveys as part of the Gateway to Global Aging Data (https://g2aging.org/). We performed cross-sectional comparisons using the 2016 wave HRS and 2015 wave CHARLS data. Age was categorized into four groups (50–59, 60–69, 70–79, and 80 years or older) and smoking and drinking behavior were combined to neither, smoking only, drinking only and both behaviors. Weighted analyses were conducted to estimate the prevalence and prevalence ratios (PRs) of heart disease accounting for complex survey design. Results The overall prevalence of heart disease was higher in men (24.5%) than in women (20.6%) in the US. In contrast, women had higher prevalence (22.9%) than men (16.1%) in China. The prevalence of heart disease increased by age with increasing gender gap in the US, while in China, the highest prevalence was observed in the 70–79 age group and gender difference were more apparent before 80 years of age. Adjusting for socio-demographic variables and health conditions, smoking only was associated with a higher prevalence of heart disease in both countries and the associations were stronger among women (US: PR = 1.39, 95%CI: 1.26 to 1.54; China: PR = 1.49, 95%CI: 1.30 to 1.72) than among men (US: PR = 1.20, 95%CI: 1.04 to 1.38; China: PR = 1.37, 95%CI: 0.94 to 1.98). Conclusions Findings from this study will improve present understanding of heart disease etiology and provide essential insights for future prevention, treatment, and control. Better management of smoking behaviors by gender might be beneficial for reducing the burden of heart disease in both countries and worldwide.

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“…However, the substantial stigma around alcohol dependence [36] may deter clinicians from such conversations with their patients, as reported in primary care [37]. Clinicians may further be discouraged to have discussions around alcohol with their patients because of several uncertainties with this topic, e.g., the differential impact on diseases—especially for cardiovascular diseases, for which both beneficial and detrimental effects have been observed (for an overview of risk functions, see reference [27]), the fact that there is no recognized “safe” level of alcohol consumption (for a recent discussion, see references [38,39,40]), or the lack of an international consensus in defining risky drinking [41].…”

Section: Discussionmentioning

confidence: 99%

Mortality from Alcoholic Cardiomyopathy: Exploring the Gap between Estimated and Civil Registry Data

Manthey

Rehm

2019

JCM

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Background: Based on civil registries, 26,000 people died from alcoholic cardiomyopathy (ACM) in 2015 globally. In the Global Burden of Disease (GBD) 2017 study, garbage coded deaths were redistributed to ACM, resulting in substantially higher ACM mortality estimates (96,669 deaths, 95% confidence interval: 82,812–97,507). We aimed to explore the gap between civil registry and GBD mortality data, accounting for alcohol exposure as a cause of ACM. Methods: ACM mortality rates were obtained from civil registries and GBD for n = 77 countries. The relationship between registered and estimated mortality rates was assessed by sex and age groups, using Pearson correlation coefficients, in addition to comparing mortality rates with population alcohol exposure—the underlying cause of ACM. Results: Among people aged 65 years or older, civil registry mortality rates of ACM decreased markedly whereas GBD mortality rates increased. The widening gap of registered and estimated mortality rates in the elderly is reflected in a decrease of correlations. The age distribution of alcohol exposure is more consistent with the distribution of civil registry rather than GBD mortality rates. Conclusions: Among older adults, GBD mortality estimates of ACM seem implausible and are inconsistent with alcohol exposure. The garbage code redistribution algorithm should include alcohol exposure for ACM and other alcohol-attributable diseases.

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Alcohol and the global burden of disease

Cited by 10 publications

References 5 publications

Assessing the impact of alcohol consumption on the genetic contribution to mean corpuscular volume

Assessing the impact of alcohol consumption on the genetic contribution to mean corpuscular volume

Gender Disparities of Heart Disease and the Association with Smoking and Alcohol Drinking Behavior Among the Middle-Aged and Older Population in the US and China, a Cross-Sectional Study of CHARLS and HRS Data

Mortality from Alcoholic Cardiomyopathy: Exploring the Gap between Estimated and Civil Registry Data

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