Alcohol and Neurodegeneration

Persidsky, Yuri; Gofman, Larisa; Potula, Raghava

doi:10.1007/978-1-4939-1071-7_24

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Neurodegenerative Diseases1

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2016

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“…It is well-Known that alcohol intake crosses the BBB (Blood–Brain Barrier) easily producing the excessive release of neurotransmitters, oxidative stress and inflammatory response which turns out in neurotoxicity and finally cell death. ( Persidsky and Potula, 2014 ).…”

Section: Neurodegenerative Diseasesmentioning

confidence: 99%

Melatonin and Other Tryptophan Metabolites Produced by Yeasts: Implications in Cardiovascular and Neurodegenerative Diseases

et al. 2016

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Yeast metabolism produces compounds derived from tryptophan, which are found in fermented beverages, such as wine and beer. In particular, melatonin and serotonin, may be relevant due to their bioactivity in humans. Indeed, the former is a neurohormone related to circadian rhythms, which also has a putative protective effect against degenerative diseases. Moreover, serotonin is a neurotransmitter itself, in addition to being a precursor of melatonin synthesis. This paper summarizes data reported on fermented beverages, to evaluate dietary intake. Additionally, the article reviews observed effects of yeast amino acid metabolites on the prevention of neurodegenerative diseases (Alzheimer’s and Parkinson’s) and angiogenesis, focusing on evidence of the molecular mechanism involved and identification of molecular targets.

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Section: Neurodegenerative Diseasesmentioning

confidence: 99%