Alcohol and Mortality from All Causes

Renaud, S.; Lanzmann‐Petithory, Dominique; Guéguen, R; Conard, Pascale

doi:10.4067/s0716-97602004000200002

Cited by 24 publications

(16 citation statements)

References 16 publications

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“…Subsequent studies in humans (Freedman et stitutes "moderate". Ethanol consumption shows a clear "J' shaped response curve with increasing intake (Renaud et al, 2004). Reduced risk with moderate intake is often attributed to "healthy" lifestyle practices other than moderate ethanol intake that happen to coincide with moderate drinking.…”

Section: Moderate Wine Consumptionmentioning

confidence: 98%

Wine and health: state of proofs and research needs

Walzem

2008

Inflammopharmacol

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Regular moderate wine consumption is often associated with reduced morbidity and mortality from to a variety of chronic diseases in which inflammation is a root cause. Wine comes in a wide variety of styles that contain quite different ethanol and polyphenol contents. Controversy remains as to whether the alcohol or polyphenols contribute more to the health benefits of regular moderate wine consumption. The variety of wines available to consumers can be expected to affect health differently in accordance with a particular wine's total polyphenolic content and spectrum of individual polyphenols. The overall effect of wine consumption on health depends upon the total amounts consumed, the style and possibly the pattern of consumption. The apparent effect of wine consumption may be modified by the non-wine diet composition of the consumer in that alcohol may appear as the primary component in consumers with high fruit, vegetable and whole grain intakes while phytochemical benefit may become significant in diets where wine is the primary dietary source of phytochemical. In this review, wine polyphenol mechanisms of action will be reviewed in connection with the mechanism the development of atherosclerotic cardiovascular disease (ASCVD). Selected clinical studies published in 2004-2008 were reviewed. Experimental requirements for valid clinical studies, translation of in vitro to in vivo application and areas where additional evidence needs to be developed were identified.

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Section: Moderate Wine Consumptionmentioning

confidence: 98%

Wine and health: state of proofs and research needs

Walzem

2008

Inflammopharmacol

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“…Other compounds in beer with anticarcinogenic capacity are 8-prenilnaringenin, isoxanthohumol (having 10–20-fold lower concentrations than the effective doses in humans in beer) and other prenilflavonoids, as well as the flavanones, humulones and proantocianidins [24]. Considering that the bioavailability of the phenolic compounds of beer is very low, their anticarcinogenic effects are somewhat controversial as many epidemiological studies have shown [107,108]. However, polyphenols from beer can reach low but effective concentrations in the colon, acting as local anti-carcinogenic agents.…”

Section: Role Of Wine and Beer In Cancer Preventionmentioning

confidence: 99%

Wine, Beer, Alcohol and Polyphenols on Cardiovascular Disease and Cancer

et al. 2012

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Since ancient times, people have attributed a variety of health benefits to moderate consumption of fermented beverages such as wine and beer, often without any scientific basis. There is evidence that excessive or binge alcohol consumption is associated with increased morbidity and mortality, as well as with work related and traffic accidents. On the contrary, at the moment, several epidemiological studies have suggested that moderate consumption of alcohol reduces overall mortality, mainly from coronary diseases. However, there are discrepancies regarding the specific effects of different types of beverages (wine, beer and spirits) on the cardiovascular system and cancer, and also whether the possible protective effects of alcoholic beverages are due to their alcoholic content (ethanol) or to their non-alcoholic components (mainly polyphenols). Epidemiological and clinical studies have pointed out that regular and moderate wine consumption (one to two glasses a day) is associated with decreased incidence of cardiovascular disease (CVD), hypertension, diabetes, and certain types of cancer, including colon, basal cell, ovarian, and prostate carcinoma. Moderate beer consumption has also been associated with these effects, but to a lesser degree, probably because of beer’s lower phenolic content. These health benefits have mainly been attributed to an increase in antioxidant capacity, changes in lipid profiles, and the anti-inflammatory effects produced by these alcoholic beverages. This review summarizes the main protective effects on the cardiovascular system and cancer resulting from moderate wine and beer intake due mainly to their common components, alcohol and polyphenols.

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“…Thus, one of the most serious and significant flaws in this theory, and hence in the National Health Policy on Alcohol in Australia of 1989, and the subsequent National Drug Strategic Plan 1993-1997, is the omission in the equation of any health benefit from light-to-moderate alcohol consumption, such as a reduction in the level and risk of cardiovascular disease and in overall mortality, which is evidenced in most, but not all, epidemiological studies, and is generally observed irrespective of gender, ethnicity and geography (Klatsky, 1990;Renaud and de Lorgeril, 1992;Klatsky and Armstrong, 1993;Maclure, 1993;Rimm et al, 1996;de Burgh, 1998;Hart et al, 1999;Renaud et al, 2004). Indeed, from the J-shaped curve ascribed to the relationship between level of consumption and risk of overall mortality, a light-to-moderate level of consumption with no occasions of heavy consumption, confers significantly more benefit than harm to health (Moore et al, 1986;Boffetta and Garfinkle, 1990;Klatsky et al, 1990;Marmot and Brunner, 1991).…”

Section: National Health Policy On Alcohol In Australia Of 1989mentioning

confidence: 99%

Moderation in Australia-Policy and Achievements

Stockley

2004

Biol. Res.

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Alcohol and Mortality from All Causes

Cited by 24 publications

References 16 publications

Wine and health: state of proofs and research needs

Wine and health: state of proofs and research needs

Wine, Beer, Alcohol and Polyphenols on Cardiovascular Disease and Cancer

Moderation in Australia-Policy and Achievements

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