Alcohol- and Light-induced Electro-oculographic Responses in Age-related Macular Degeneration &amp; Central Serous Chorioretinopathy

Wu, Kathy H C; Marmor, Michael F.

doi:10.1007/s10633-005-0649-z

Cited by 6 publications

(5 citation statements)

References 25 publications

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“…Even if a 95%; criterion is used, the lower value (one might guess from our limited sample that it would be below 1.2) will be so close to 1.0 that in practical clinical terms it will be difficult to differentiate a subnormal value from a low to normal response. Nevertheless, the Alc-EOG may still have value, in following a disease process or for comparing mean or median response amplitudes between groups of normal and diseased subjects, as we demonstrate in a companion paper with respect to ARMD and CSC [24].…”

Section: Discussionmentioning

confidence: 92%

Alcohol- and Light-induced Electro-oculographic Responses: Variability and Clinical Utility

Marmor

2005

Doc Ophthalmol

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The alcohol-induced electro-oculographic (EOG) response has been proposed by Arden as an indicator of retinal pigment epithelial (RPE) integrity. We have evaluated the consistency of the alcohol-EOG with respect to clinical applicability and compared this response to the ISCEV-standard EOG. We recorded, in a group of normal subjects (n=29, 14 men with mean age 42+/-11 years and 15 women with mean age 36+/-13 years), the alcohol response to a single oral dose of ethanol at 160 mg/kg (as 40 proof vodka, drunk in 15 s after 12 h of fasting), followed by an ISCEV-standard EOG 90 min after alcohol administration. Blood alcohol levels were monitored at regular intervals with a breath analyzer. We found a wide range of amplitudes in both light and alcohol responses among participants, from minimal to large values. Subjects had a wide range of blood alcohol concentrations from 0.02 to 0.10%; near the time of the response peak, but there was no relationship between alcohol levels and peak/baseline ratios. In addition, there was no relationship between alcohol peak/baseline ratio and the Arden ratio. Neither the alcohol nor the light response parameters showed any relationship with age or gender. Some of the inter-individual variability in the EOG response to alcohol may reflect variable absorption of oral alcohol. The alcohol-induced EOG has too broad a range of responses to be useful clinically for the one-time evaluation of individual patients. We have similar concerns regarding clinical applications of the standard light-induced EOG.

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Section: Discussionmentioning

confidence: 92%

Alcohol- and Light-induced Electro-oculographic Responses: Variability and Clinical Utility

Marmor

2005

Doc Ophthalmol

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“…[27][28][29] to more cleanly assess RPE function uncontaminated by photoreceptor status. Indeed, Shirao and Kawasaki [27] demonstrated that these measures are affected in diabetes.…”

Section: Discussionmentioning

confidence: 99%

The fast oscillation of the EOG in diabetes with and without mild retinopathy

2007

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There is ample evidence that the retinal pigment epithelium (RPE) is affected in diabetes, and that epitheliopathy may be among the early changes. The fast oscillation (FO) of the electro-oculogram (EOG) reflects the activity of the RPE, most notably the mechanisms responsible for pumping fluid and ions in the retina-to-choroid direction. The FO was measured in three groups of subjects: normal controls, eyes of diabetic individuals with no evidence of retinopathy, and eyes of diabetics with mild background retinopathy. FO amplitude, light trough voltage and dark peak voltage in both diabetic groups were all significantly reduced, independent of retinopathy status. The peak to trough ratio was unaffected. These changes, reduced voltages and smaller light-evoked voltage changes, are consistent with a decrease in the resistance of the RPE and may relate to accumulation of fluid in the sub-retinal space.

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“…Elle reste cantonnée au cadre expérimental [Gallemore et al, 1998], [Wu, Marmor, 2005]. L'enregistrement se fait comme pour un EOG, en effectuant des mouvements oculaires réguliers, le sujet restant dans l'obscurité.…”

Section: En Pratique…unclassified

Iii-3 : l'EPITHELIUM Pigmentaire : Quelques Aspects Fonctionnels

Rigaudière¹

2010

Oeil Et Physiologie De La Vision

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Première partie : Caractéristiques et rôles Situation Contiguïté avec la neurorétine Matrice interphotorécepteurs Canaux et transporteurs Membrane apicale Membrane basale Rôles de l'épithélium pigmentaire Phagocytose de l'article externe des photorécepteurs Renouvellement de la rhodopsine Protection de la neurorétine Transport transépithélial Différence de potentiel transépithéliale : PTE Deuxième partie : bases physiologiques de l'EOG Evaluation de la PTE Au début d'un éclairement… Au cours d'un éclairement… Durant une quinzaine de minutes Durant plusieurs heures Alternance éclairement-obscurité Retour à l'obscurité Lien avec l'EOG Hypothèses Mesure indirecte de l'amplitude du dipôle : l'EOG Superposition entre la variation de PTE et l'EOG ? Conséquences pour l'exploration visuelle Conclusion

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Alcohol- and Light-induced Electro-oculographic Responses in Age-related Macular Degeneration & Central Serous Chorioretinopathy

Cited by 6 publications

References 25 publications

Alcohol- and Light-induced Electro-oculographic Responses: Variability and Clinical Utility

Alcohol- and Light-induced Electro-oculographic Responses: Variability and Clinical Utility

The fast oscillation of the EOG in diabetes with and without mild retinopathy

Iii-3 : l'EPITHELIUM Pigmentaire : Quelques Aspects Fonctionnels

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