Alcohol and fertility: how much is too much?

Heertum, Kristin Van; Rossi, Brooke V.

doi:10.1186/s40738-017-0037-x

Cited by 48 publications

(39 citation statements)

References 55 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…On the other hand, the effects of low to moderate consumption of alcohol do not appear to be clinically significant. Several studies have shown no effect in semen parameters with moderate alcohol consumption (Stutz et al 2004, Van Heertum & Rossi 2017. de Jong et al (2014) failed to show a significant relationship between alcohol consumption and not only sperm parameters but also pregnancy outcome.…”

Section: Introductionmentioning

confidence: 99%

“…Numerous studies have shown the deleterious effects of chronic heavy alcohol consumption on testicular function and spermatogenesis (Shayakhmetova et al 2013(Shayakhmetova et al , 2014, on testosterone serum levels (Salonen et al 1992, Muthusami & Chinnaswamy 2005, Lee et al 2010, Jensen et al 2014, Sliwowska et al 2016) and on hypothalamic-pituitary-testicular axis function (Cicero & Badger 1977, Dees et al 1990, Välimäki et al 1990, Salonen et al 1992, Zhang et al 2005. Clinical manifestations in alcoholic men include hypogonadism, testicular atrophy, feminization, sexual dysfunction (Van Thiel et al 1990, Van Heertum & Rossi 2017, infertility and delayed sexual maturation (Anderson et al 1989). Many studies have suggested that one of the most important negative effects of chronic alcohol ingestion occur in sperm parameters (Rahimipour et al 2013,Condorelli et al 2015.…”

Section: Introductionmentioning

confidence: 99%

“…Others have observed a positive effect of male alcohol intake on fertilization rate (Firns et al 2015). Regarding duration of alcohol exposure, multiple studies have showed altered sperm morphology with regular alcohol drinking, correlating with low fecundity (Van Heertum & Rossi 2017). Chronic consumption of 5% ethanol for 20 weeks or 6% ethanol for 5 weeks (that produced 45% ethanolderived calories (EDC)) led to low caudal sperm content in rats (Anderson et al 1983, Willis et al 1983.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Murine sperm capacitation, oocyte penetration and decondensation following moderate alcohol intake

Sanchez¹,

Fontana²,

Galotto³

et al. 2018

Reproduction

View full text Add to dashboard Cite

Male chronic alcohol abuse causes testicular failure and infertility. We analyzed the effects of moderate sub-chronic alcohol intake on sperm morphology, capacitation, fertilization and sperm head decondensation. CF-1 male mice were administered 15% ethanol in drinking water for 15 days; control mice received ethanol-free water. Similar patterns of tyrosine phosphorylation were observed in capacitated spermatozoa of control and treated males. Percentage of hyperactivation (H) and spontaneous (SAR) and progesterone-induced (IAR) acrosome reaction significantly decreased at 120 and 150 min of capacitation in treated males compared to controls (H: 14.1 ± 2.5 vs 23.7 ± 2.6, < 0.05; SAR-T120 min: 17.9 ± 2.5 vs 32.9 ± 4.1, < 0.01; IAR-150 min: 43.3 ± 3.5 vs 73.1 ± 1.1, < 0.001, = 6). During fertilization (2.5, 3.5 and 4.5 h post-insemination), there was an increased percentage of fertilized oocytes (with a decondensed sperm head and one or two pronuclei) in treated males ( < 0.001, = 7). After 60 min of decondensation with glutathione plus heparin, the percentage of decondensed sperm heads was significantly higher in treated males than in controls (mean ± s.d.: 57.1 ± 5.6 vs 48.3 ± 4.5, < 0.05, = 5). The percentage of morphologically normal sperm heads was significantly decreased in treated males with respect to controls ( < 0.001, = 9). These results show that short-term moderate alcohol consumption in outbred mice affect sperm morphology, hyperactivation, acrosomal exocytosis, and the dynamics of fertilization and sperm nuclear decondensation.

show abstract

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Murine sperm capacitation, oocyte penetration and decondensation following moderate alcohol intake

Sanchez¹,

Fontana²,

Galotto³

et al. 2018

Reproduction

View full text Add to dashboard Cite

show abstract

“…Other direct effects of alcohol on the female endocrine system have been reported (Rachdaoui and Sarkar 2017), resulting in irregular menstrual/estrous cycles, anovulation, early menopause and elevated estradiol (E2) levels in both women and rodents. High alcohol consumption has also been suggested to negatively impact on assisted reproductive outcomes, with reduced oocytes retrieved, lower rates of pregnancy and increased risk for miscarriage (see Van Heertum and Rossi (2017) for review).…”

Section: Introductionmentioning

confidence: 99%

Moderate episodic prenatal alcohol does not impact female offspring fertility in rats

McReight

Liew

Steane

et al. 2020

Preprint

View full text Add to dashboard Cite

25Prenatal alcohol exposure (PAE) has been associated with reproductive dysfunction in 26 offspring. However, studies in females, particularly examining long-term infertility or 27 impacts on ovarian reserve, are lacking. The current study utilised a moderate, episodic 28 exposure model in rats to mimic 'special occasion' drinking, which is reported to be common 29 during pregnancy. Our objective was to examine the consequences of this prenatal alcohol 30 exposure on reproductive parameters in female offspring. Pregnant Sprague Dawley rats were 31 treated with either an ethanol gavage (1g EtOH/kg body weight), or an equivalent volume of 32 saline, on embryonic days 13.5 and 14.5 of pregnancy, resulting in a peak blood alcohol 33 concentration of ~0.04%. Neonatal female offspring were examined for molecular markers 34 regulating early follicle numbers in the ovary and unbiased stereology used to quantify 35 primordial and early growing follicle numbers. Puberty onset (age at vaginal opening and 36 first estrous) was measured post-weaning and estrous cycles, reproductive hormones 37 (progesterone and estradiol) and pregnancy success measured in adults (5-6 months of age). 38 We found no evidence that any of these reproductive parameters were significantly altered by 39 PAE in this model. This animal study provides some reassurance for women who may have 40 consumed a small amount of alcohol during their pregnancy. However, previously published 41 effects on offspring metabolism using this model reinforce avoidance of alcohol during 42 pregnancy. 43 44 45 479 treatments and husbandry; Erica Mu (School of Biomedical Sciences Histology Facility, 480 University of Queensland) for serial sectioning of neonatal ovaries; Shaun Walters (School of 481 Biomedical Sciences Imaging Facility, University of Queensland) for technical assistance 482 with stereology; Tam Nguyen (School of Biomedical Sciences, University of Queensland) for 483 assistance with animal work; and Jacobus Ungerer (Pathology Queensland, Queensland 484 Health) for analysis of BAC. 485 486 21 References 487 Akison, LK, KM Moritz, and N Reid 2019 Adverse reproductive outcomes associated with 488 fetal alcohol exposure: a systematic review. Reproduction 157 329-343. 489 Alviggi, C, P Humaidan, CM Howles, D Tredway, and SG Hillier 2009 Biological versus 490 chronological ovarian age: implications for assisted reproductive technology. Reprod 491 Biol Endocrinol 7 101. 492 Bernal, AB, MH Vickers, MB Hampton, RA Poynton, and DM Sloboda 2010 Maternal 493 undernutrition significantly impacts ovarian follicle number and increases ovarian 494 oxidative stress in adult rat offspring. PLoS One 5 e15558. 495 Boggan, WO, CL Randall, and HM Dodds 1979 Delayed sexual maturation in female 496 C57BL/6J mice prenatally exposed to alcohol. Res Commun Chem Pathol Pharmacol 497 23 117-125. Hansbro, EA McLaughlin, and JE Holt 2016 Maternal smoke exposure impairs the 500 long-term fertility of female offspring in a murine model. Biol Reprod 94 39. 501 Choi, JI, K...

show abstract

“…However, there is always the possibility of premature birth, low birth weight, birth defects, infant death, and abortion (5). According to previous studies, there are various reasons for the loss of the pregnancy, such as endocrine causes (e.g., luteal phase defects (6), diabetes (7), hypothyroidism (8), and polycystic ovaries (9)), infectious causes (10), anatomical defects of the uterus (11), environmental causes (e.g., smoking (12), alcohol consumption (13), air pollution (14), and excessive coffee consumption (15)), and old age of parents (4,16,17). In infertility centers, only the medically known factors are considered and examined in infertile couples and in many cases, despite the elimination of all barriers to fertility and the use of pharmacological and invasive methods, the success rate of fertility is still very low.…”

Section: Introductionmentioning

confidence: 99%

Relationship between the Time of Intrauterine Insemination and Pregnancy Outcome, Based on Islamic Recommendations

Qomi

tabatabaei

Heidari

et al. 2020

Health Spiritual Med Ethics

View full text Add to dashboard Cite

Background and Objectives: Intrauterine insemination (IUI) is one of the methods of infertility treatment. When is the best time to do this assisted reproduction procedure? There are many Islamic narrations about the appropriate time for fertilization in order to give birth to a physically, mentally, and spiritually healthy child. Therefore, this study examined the relationship between the time of IUI performance and its consequences according to Islamic narrations. Methods: The present historical cohort study was conducted at an Infertility Center affiliated with the Academic Center for Education, Culture, and Research of Qom, Iran using the medical records of patients who underwent sex selection IUI procedure from 2011 to 2015. The data were collected using a researcher-made checklist consisting of demographic characteristics, factors affecting the pregnancy outcome in terms of medicine and narrations, as well as the pregnancy outcome. The collected data were analyzed in SPSS software (version 20). Results: The findings indicated that the time of IUI performance based on Islamic recommendations and the pregnancy test result had a significant relationship (P=0.003). Moreover, the time of IUI based on Islamic recommendations had a significant relationship with pregnancy outcomes (P=0.023). The highest number of abortions and neonatal disorders were observed in pregnancies that had happened at the disapproved times according to the narrations (e.g., the end of the lunar month and when the moon is in Scorpio). Besides, the highest number of births of healthy infants happened when the insemination had happened at the recommended times (e.g., Thursday noon). Conclusion: Due to the relationship between the time of IUI based on Islamic recommendations and the pregnancy outcome, it is recommended that IUI be performed based on Islamic recommendations and at times other than the disapproved times so that better results will be achieved in pregnancy. However, further studies are needed in this regard.

show abstract

Alcohol and fertility: how much is too much?

Cited by 48 publications

References 55 publications

Murine sperm capacitation, oocyte penetration and decondensation following moderate alcohol intake

Murine sperm capacitation, oocyte penetration and decondensation following moderate alcohol intake

Moderate episodic prenatal alcohol does not impact female offspring fertility in rats

Relationship between the Time of Intrauterine Insemination and Pregnancy Outcome, Based on Islamic Recommendations

Contact Info

Product

Resources

About