Alcohol and calcium make a potent cocktail

Iwakiri, Yasuko; Nathanson, Michael H.

doi:10.1113/jp274133

Cited by 1 publication

(1 citation statement)

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“… 103 Perturbations in Ca2+ signaling can affect mitochondrial function and contribute to mitochondrial reactive oxygen species formation and opening of the permeability transition pore (PTP). 104 The combination of AALD and the pathological stress induced by COVID-19 infection may exacerbate hepatic dysfunction and worsen clinical outcomes, as demonstrated in our study. Targeting these mechanisms associated with chronic liver diseases, such as modulating Ca2+ signaling pathways and mitochondrial function, holds potential for therapeutic interventions to mitigate the impact of COVID-19-related cholangiopathy in susceptible populations.…”

Section: Opportunities For Interventionsupporting

confidence: 62%

Clinical and Histopathological Discoveries in Patients with Hepatic Injury and Cholangiopathy Who Have Died of COVID-19: Insights and Opportunities for Intervention

Lim,

Njei

2023

HMER

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The COVID-19 pandemic has had a profound impact on global health, necessitating a comprehensive understanding of its diverse manifestations. Cholangiopathy, a condition characterized by biliary dysfunction, has emerged as a significant complication in COVID-19 patients. In this review, we report the epidemiology of COVID-19, describe the hepatotropism of SARS-CoV-2, and present the histopathology of acute liver injury (ALI) in COVID-19. Additionally, we explore the relationship between pre-existing chronic liver disease and COVID-19, shedding light on the increased susceptibility of these individuals to develop cholangiopathy. Through an in-depth analysis of cholangiopathy in COVID-19 patients, we elucidate its clinical manifestations, diagnostic criteria, and underlying pathogenesis involving inflammation, immune dysregulation, and vascular changes. Furthermore, we provide a summary of studies investigating post-COVID-19 cholangiopathy, highlighting the long-term effects and potential management strategies for this condition, and discussing opportunities for intervention, including therapeutic targets, diagnostic advancements, supportive care, and future research needs.

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Section: Opportunities For Interventionsupporting

confidence: 62%