Alcohol and caffeine consumption and decreased fertility

Hakim, Rosemarie B.; Gray, Ronald H.; Zacur, Howard A.

doi:10.1016/s0015-0282(98)00257-x

Cited by 188 publications

(111 citation statements)

References 32 publications

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“…There is evidence that smoking and alcohol consumption reduce fertility in women by elevating OS (17,18). Evidence also indicates that dietary antioxidant and diet-related exposures to ROS affect the timing and maintenance of pregnancy (19).…”

Section: Discussionmentioning

confidence: 99%

Uterine FK506-binding protein 52 (FKBP52)–peroxiredoxin-6 (PRDX6) signaling protects pregnancy from overt oxidative stress

Hirota

Acar

Tranguch

et al. 2010

Proc. Natl. Acad. Sci. U.S.A.

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Immunophilin FK506-binding protein 52 (FKBP52) is a cochaperone that binds to the progesterone receptor (PR) to optimize progesterone (P 4 )-PR signaling. We recently showed that Fkbp52-deficient (Fkbp52 −/− ) mice have reduced uterine PR responsiveness and implantation failure which is rescued by excess P 4 supplementation in a genetic background-dependent manner. This finding led us to hypothesize that FKBP52 has functions in addition to optimizing PR activity. Using proteomics analysis, we found that uterine levels of peroxiredoxin-6 (PRDX6), a unique antioxidant, are significantly lower in Fkbp52 −/− mice than in WT and PR-null (Pgr −/− ) mice. We also found that Fkbp52 −/− mice with reduced uterine PRDX6 levels are susceptible to paraquat-induced oxidative stress (OS), leading to implantation failure even with P 4 supplementation. The same dose of paraquat did not interfere with implantation in WT mice. Moreover, treatment with antioxidants α-tocopherol and N-acetylcysteine (NAC) attenuated paraquat-induced implantation failure in P 4 -treated Fkbp52 −/− mice. Functional analyses using mouse embryonic fibroblasts show that Fkbp52 deficiency associated with reduced PRDX6 levels promotes H 2 O 2 -induced cell death, which is reversed by the addition of NAC or by forced expression of PRDX6, suggesting that Fkbp52 deficiency diminishes the threshold against OS by reducing PRDX6 levels. These findings provide evidence that heightened uterine OS in Fkbp52 −/− females with reduced PRDX6 levels induces implantation failure even in the presence of excess P 4 . This study shows that FKBP52-PRDX6 signaling protects pregnancy from overt OS.embryo implantation | mouse | uterus

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Section: Discussionmentioning

confidence: 99%

Uterine FK506-binding protein 52 (FKBP52)–peroxiredoxin-6 (PRDX6) signaling protects pregnancy from overt oxidative stress

Hirota

Acar

Tranguch

et al. 2010

Proc. Natl. Acad. Sci. U.S.A.

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“…Previous preconception cohort studies have evaluated the relationship between preconception cigarette use and TTP. Maternal preconception smoking is associated with longer TTP in most [17][18][19][20][21][22] but not all 23 studies. The relationship between paternal preconception smoking and TTP is more ambiguous, with one study reporting a nonsignificantly longer TTP, 19 a second reporting a significantly shorter TTP, 23 and two reporting no association with TTP 20,22 among male smokers compared with nonsmokers.…”

Section: Introductionmentioning

confidence: 99%

Time-to-Pregnancy Associated With Couples’ Use of Tobacco Products

Sapra

Barr

Maisog

et al. 2016

NICTOB

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Introduction: Previous studies suggest female smoking increases time-to-pregnancy (TTP), a couple-dependent reproductive outcome, while associations with male smoking are more ambiguous. Furthermore, despite small increases in smokeless tobacco use in the United States, no prior study has evaluated TTP among smokeless tobacco users. Methods: Using population-based sampling in 16 counties in Michigan and Texas, 501 couples discontinuing contraception to become pregnant were followed until positive pregnancy test or 12 months of trying. Participants were interviewed on lifetime and current cigarette, cigar, and chew/snuff (smokeless) use and provided blood samples for quantification of heavy metals and cotinine. Fecundability odds ratios (FORs) and 95% confidence intervals (95% CIs) were estimated, adjusted for demographics/lifestyle. FORs less than 1 reflect longer TTP. Results: Eleven percentage of females and 15% of males smoked cigarettes. Among men, 14% smoked cigars, 9% used snuff, and 2% used chew. Compared with never tobacco users, male (FOR: 0.41, 95% CI: 0.24, 0.68) and female (FOR: 0.53, 95% CI: 0.33, 0.85) smoking were individually associated with longer TTP; males' smoking remained significant (FOR: 0.46, 95% CI: 0.27, 0.79) when modeling partners together. Cadmium levels were higher in smokers than smokeless tobacco and never users; adjusting for cadmium attenuated the cigarette-TTP association, particularly among women. TTP was shorter among smokeless tobacco users relative to smokers (FOR: 2.86, 95% CI: 1.47, 5.57). Conclusions: Compared with never users, smokeless tobacco did not alter TTP in our cohort; however, TTP was shorter compared with smokers. We observed longer TTP in male and female smokers; cadmium may partially contribute. Implications: Both partners' preconception smoking contributed to longer TTP, highlighting the importance of both partners' lifestyles in healthy reproduction and underscores the need for couple-based preconception guidance. The male's contribution is a new finding. Higher cadmium levels may partially contribute to longer TTP in smokers, particularly among females. Though we do not observe longer TTP among a small sample of smokeless tobacco users compared with never tobacco users, we observe shorter TTP compared with smokers. Further work is needed to more thoroughly delineate the relationship between smokeless tobacco use and TTP and possible mechanisms of tobacco use's effects on reproduction.

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“…There are a number of dietary factors that impact upon the human reproductive system. Heavy alcohol consumption has been shown to affect both female and male fertility (Grodstein et al, 1994, Hakim et al, 1998, Klonoff-Cohen et al, 2003, Windham et al, 1992. In men, alcohol consumption can induce testicular atrophy, impotence, reduced libido and cause a deterioration in sperm count (Donnelly et al, 1999, Muthusami and Chinnaswamy, 2005, Olsen et al, 1997.…”

Section: Relationship Between Lifestyle Diabetes Mellitus and Infertmentioning

confidence: 99%