Alcohol Administration Increases Cocaine Craving But Not Cocaine Cue Attentional Bias

Marks, Katherine R.; Pike, Erika; Stoops, William W.; Rush, Craig R.

doi:10.1111/acer.12824

Cited by 18 publications

(20 citation statements)

References 46 publications

(77 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Alcohol administration produced prototypical subject-rated (e.g., drink more, drunk, sedated) and physiological (e.g., blood pressure, heart rate, BrAC) drug-effects consistent with the findings of other studies with cocaine users (Higgins et al, 1993, 1996; Marks et al, 2015). Replicating a novel finding observed previously in our laboratory, cocaine craving was increased following alcohol administration (Marks et al, 2015).…”

Section: Discussionsupporting

confidence: 83%

“…Replicating a novel finding observed previously in our laboratory, cocaine craving was increased following alcohol administration (Marks et al, 2015). The previous study was the first to show an increase in cocaine craving in cocaine users following 0.325 and 0.65 g/kg alcohol administration (Marks et al, 2015). This critical replication of induced cocaine craving in a larger sample may help to explain the mechanism by which alcohol consumption contributes to cocaine relapse.…”

Section: Discussionsupporting

confidence: 76%

“…Although a higher alcohol dose would have better represented the subjects’ naturalistic drinking patterns, 0.65 g/kg alcohol was a behaviorally active dose and in previous research significantly increased the proportion of inhibitory failures on the ABBA task following alcohol cues (Weafer and Fillmore, 2015). Administration of 0.65 g/kg alcohol reliably increases increases ratings of subject-rated drug-effects (Fillmore et al, 2005; Marczinski and Fillmore, 2005; Marks et al, 2015; Weafer and Fillmore, 2015). This dose is also socially relevent as it produces peak BrACs of approximately 80 mg/100ml, which is the legal limit for intoxication for driving in the United States.…”

Section: Discussionmentioning

confidence: 95%

“…On the Cocaine Craving Questionnaire (Dudish-Poulsen and Hatsukami, 1997; Marks et al, 2015), subjects rated how much they Want Cocaine, Need Cocaine, and Crave Cocaine from Not at All (i.e., score of 0) to Extremely (i.e., score of 4). On the Drug Effect Questionnaire (Rush et al, 2011) subjects rated how the drink made them feel on a 100-mm visual analog scale.…”

Section: Methodsmentioning

confidence: 99%

See 3 more Smart Citations

Influence of Cocaine‐Related Images and Alcohol Administration on Inhibitory Control in Cocaine Users

Pike

Marks

Stoops

et al. 2017

Alcoholism Clin & Exp Res

Self Cite

View full text Add to dashboard Cite

Background Alcohol use and impulsivity, including decreased inhibitory control, predict poor treatment outcomes for individuals with cocaine use disorders. This study sought to determine the effects of alcohol administration on inhibitory control following cocaine-related and neutral cues on the Attentional Bias-Behavioral Activation (ABBA) task in cocaine users. We hypothesized that the proportion of inhibitory failures would increase following cocaine cues compared to neutral cues. We further hypothesized that there would be an interaction between alcohol administration and task version, such that alcohol would impair inhibitory control following cocaine, but not neutral cues. Methods Fifty current cocaine users completed this mixed-model, double-blind, placebo-controlled, cross-over study over two experimental sessions. The ABBA task was completed following alcohol administration (0.0 and 0.65 g/kg). Subject-rated drug-effect and physiological measures were collected prior to and after alcohol administration. Results Proportion of inhibitory failures was increased following cocaine-related cues compared to neutral cues independent of alcohol dose. Alcohol administration also produced prototypical subject-rated drug-effects. Conclusions A better understanding of the relationship between alcohol consumption and inhibitory control in cocaine users could direct the development of interventions to decrease the risk of relapse in individuals who drink and display impaired inhibitory control.

show abstract

Section: Discussionsupporting

confidence: 83%

Section: Discussionsupporting

confidence: 76%

Section: Discussionmentioning

confidence: 95%

Section: Methodsmentioning

confidence: 99%

See 2 more Smart Citations

Influence of Cocaine‐Related Images and Alcohol Administration on Inhibitory Control in Cocaine Users

Pike

Marks

Stoops

et al. 2017

Alcoholism Clin & Exp Res

Self Cite

View full text Add to dashboard Cite

show abstract

“…In terms of behavioral mechanisms involved in this interaction, alcohol consumption has been reported to increase cocaine craving and has also been shown to be an antecedent to cocaine relapse (Marks et al, 2015; McKay et al, 1999). It is well established that cocaine-associated cues are involved in maintaining drug-taking behavior (Childress et al, 1999; Kosten et al, 2006; Sinha and Li, 2007; Volkow et al, 2008) and attentional bias towards such cues has been positively correlated with cocaine craving (Field et al, 2009; Leeman et al, 2014; Rosse et al, 1997).…”

Section: Discussionmentioning

confidence: 99%

Effects of ethanol on cocaine self-administration in monkeys responding under a second-order schedule of reinforcement

John

Nader

2017

Drug and Alcohol Dependence

View full text Add to dashboard Cite

Background Concurrent alcohol use among cocaine abusers is common but the behavioral variables that promote co-abuse are not well understood. The present study examined the effects of intragastric (i.g.) ethanol (EtOH) administration in monkeys responding under a schedule of cocaine reinforcement in which extensive drug seeking was maintained by conditioned stimuli. Methods Four adult male cynomolgus monkeys (Macaca fascicularis) were trained to respond under a second-order fixed-interval (FI) 600-s (fixed-ratio (FR) 30:S) schedule of cocaine (0.003–0.56 mg/kg/injection) presentation. Sessions ended after 5 injections or 90 min had elapsed. Different EtOH doses (0.5–2.0 g/kg, i.g.) were administered 30 min before the session, typically on Tuesdays and Fridays. Blood ethanlol concentrations (BECs) were also assessed. Pattern of FI responding was assessed by determining quarter-life (QL) values. Results Cocaine self-administration was characterized as an inverted U-shaped function of dose; QL values increased monotonically with dose. EtOH pretreatments dose-dependently decreased self-administration at several cocaine doses in 3 of 4 monkeys. In one animal, EtOH increased low-dose cocaine-maintained responding. For all monkeys, QL values were increased by EtOH when low- and high-cocaine doses were self-administered, suggesting additive effects of EtOH and cocaine. Furthermore, BECs were not altered following cocaine self-administration. Conclusions The reductions in cocaine self-administration and the increases QL values following EtOH, suggest that EtOH was enhancing cocaine-related conditioned reinforcement. A better understanding of the behavioral mechanisms that mediate the co-abuse of alcohol and cocaine will lead to improved treatments for both drugs.

show abstract

Association of Alcohol Screening Scores With Adverse Mental Health Conditions and Substance Use Among US Adults

et al. 2020

View full text Add to dashboard Cite

IMPORTANCE Alcohol screening may be associated with health outcomes that cluster with alcohol use (ie, alcohol-clustering conditions), including depression, anxiety, and use of tobacco, marijuana, and illicit drugs. OBJECTIVE To quantify the extent to which alcohol screening provides additional information regarding alcohol-clustering conditions and to compare 2 alcohol use screening tools commonly used for this purpose. DESIGN, SETTING, AND PARTICIPANTS This longitudinal cohort study used data from the Veterans Aging Cohort Study. Data were collected at 8 Veterans Health Administration facilities from 2003 through 2012. A total of 7510 participants were enrolled, completed a baseline survey, and were followed up. Veterans with HIV were matched with controls without HIV by age, race, sex, and site of care. Data were analyzed from January 2019 to December 2019. EXPOSURES The Alcohol Use Disorders Identification Test (AUDIT) and Alcohol Use Disorders Identification Test-Consumption (AUDIT-C) were used to assess alcohol use, with 4 risk groups delineated for each test: score 0 to 7 (reference), score 8 to 15, score 16 to 19, and score 20 to 40 (maximum score) for the full AUDIT and score 0 to 3 (reference), score 4 to 5, score 6 to 7, and score 8 to 12 (maximum score) for the AUDIT-C. MAIN OUTCOMES AND MEASURES Alcohol-clustering conditions, including self-reported symptoms of depression and anxiety and use of tobacco, marijuana, cocaine, other stimulants, opioids, and injection drugs. RESULTS A total of 6431 US patients (6104 [95%] men; median age during survey years 2003-2004, 50 years [range, 28-86 years; interquartile range, 44-55 years]) receiving care in the Veterans Health Administration completed 1 or more follow-up surveys when the AUDIT was administered and were included in the present analyses. Of the male participants, 4271 (66%) were African American, 1498 (24%) were white, and 590 (9%) were Hispanic. The AUDIT and AUDIT-C scores were associated with each alcohol-clustering condition. In particular, an AUDIT score of 20 or higher

show abstract

Alcohol Administration Increases Cocaine Craving But Not Cocaine Cue Attentional Bias

Cited by 18 publications

References 46 publications

Influence of Cocaine‐Related Images and Alcohol Administration on Inhibitory Control in Cocaine Users

Influence of Cocaine‐Related Images and Alcohol Administration on Inhibitory Control in Cocaine Users

Effects of ethanol on cocaine self-administration in monkeys responding under a second-order schedule of reinforcement

Association of Alcohol Screening Scores With Adverse Mental Health Conditions and Substance Use Among US Adults

Contact Info

Product

Resources

About