Alcohol accumulation promotes esophagitis via pyroptosis activation

Wang, Fengjiao; Li, Gang; Ning, Jinfeng; Chen, Lantao; Xu, Hai; Kong, Xianglong; Bu, Jianlong; Zhao, Weiwei; Li, Zhengtian; Wang, Xiuyun; Li, Xiaoguang; Ma, Jianqun

doi:10.7150/ijbs.24347

Cited by 36 publications

(27 citation statements)

References 68 publications

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“…448 Ac-YVAD-CMK, an irreversible and selective inhibitor of caspase-1, effectively blocked the cleavage of pro-IL-1β and pro-IL-18 and reduced the inflammatory response and is expected to be used to inhibit the progression of esophagitis. 449 Furthermore, Ac-YVAD-CMK suppressed IFI16- or berberine-induced tumor inhibition in hepatocellular carcinoma 335 , 450 (Fig. 6 ).…”

Section: Therapeutic Implicationsmentioning

confidence: 84%

Pyroptosis: mechanisms and diseases

Zhang

Liu

et al. 2021

Sig Transduct Target Ther

1,136

799

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Currently, pyroptosis has received more and more attention because of its association with innate immunity and disease. The research scope of pyroptosis has expanded with the discovery of the gasdermin family. A great deal of evidence shows that pyroptosis can affect the development of tumors. The relationship between pyroptosis and tumors is diverse in different tissues and genetic backgrounds. In this review, we provide basic knowledge of pyroptosis, explain the relationship between pyroptosis and tumors, and focus on the significance of pyroptosis in tumor treatment. In addition, we further summarize the possibility of pyroptosis as a potential tumor treatment strategy and describe the side effects of radiotherapy and chemotherapy caused by pyroptosis. In brief, pyroptosis is a double-edged sword for tumors. The rational use of this dual effect will help us further explore the formation and development of tumors, and provide ideas for patients to develop new drugs based on pyroptosis.

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Section: Therapeutic Implicationsmentioning

confidence: 84%

Pyroptosis: mechanisms and diseases

Zhang

Liu

et al. 2021

Sig Transduct Target Ther

1,136

799

View full text Add to dashboard Cite

show abstract

“… 30 Additionally, Chen et al 31 showed that NLRP3 could active IL‐1β, which is associated with antineoplastic immune responses and tumor development in head and neck squamous cell carcinoma. Furthermore, Wang et al 32 showed that the accumulation of alcohol in the esophagus could trigger caspase‐1‐mediated pyroptosis and the release of IL‐1β and IL‐18, which may be involved in esophageal cancer. Barrett's esophagus (BE) can also activate caspase‐1‐dependent pyroptosis and cause the release of IL‐1β and IL‐18 to enhance the progression of esophageal cancer.…”

Section: The Role Of Pyroptosis In the Association Between Cancer And The Immune Systemmentioning

confidence: 99%

Pyroptosis, a new bridge to tumor immunity

et al. 2021

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Environmental factors and genetic mutation have caused cancer incidence and mortality to rapidly increase. Cancer has become one of the crucial causes of death worldwide, and is becoming a major public health problem. 1 The traditional core types of cancer treatment are surgery, chemo-therapy, and radiation therapy, which can reduce tumor cell proliferation by inducing cancer cell death. 2 However, accumulating evidence has shown that tumors often relapse and it has been suggested that successful oncotherapy requires prolonged antineoplastic immunity. 3 The field of cancer immunotherapy (CIT) has emerged in recent years and aims to stimulate the body's immune system to create a robust immune response that can kill cancer cells. 4 This type of treatment can induce immunogenic cell death in different ways and achieve long-term anticancer immunity. 5 Although the application of CIT has been considered for a broad range of tumors, only a minority of patients achieve a satisfactory treatment effect due to immune escape. These results indicate that the immune system is intricate and still not well managed. 6 Thus, it is necessary to explore the mechanisms involved in CIT to develop more efficient methods of treatment for better cancer prevention and treatment.

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“…Caspase-1 is considered as a pro-inflammatory mediator in GERD. Under conditions of alcohol-induced esophagitis in cell culture and in vivo, was found caspase-1 activation and DNA fragmentation [14]. Caspase-1 converts inactive pro-IL-1β and pro-IL-18 into active pro-inflammatory cytokines, enhances the inflammatory response, induces pyroptosis an inflammatory cell death after its activation various inflammasomes, thus pyroptosis was involved in the occurrence of esophagitis [15,16].…”

Section: Discussionmentioning

confidence: 98%

“…Caspase-1 converts inactive pro-IL-1β and pro-IL-18 into active pro-inflammatory cytokines, enhances the inflammatory response, induces pyroptosis an inflammatory cell death after its activation various inflammasomes, thus pyroptosis was involved in the occurrence of esophagitis [15,16]. The use of an inhibitor of caspase-1 could suppress the activity of IL-1 and IL-18 in vivo and in vitro reducing the inflammatory response so may considered as future therapeutic target [14]. Similar results in determining the role of caspase-1 were obtained in an animal model of esophagitis induced by the introduction of bile acid salts [17].…”

Section: Discussionmentioning

confidence: 99%

Caspase-Dependent Activation of Cascade Cytokines in Young Patients With Autoimmune Thyroiditis in Combination With Gastroesophageal Reflux Disease

et al. 2021

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The aim of the study: to assess the role of caspase-1 and IL-18 in the implementation of the inflammatory response in young patients with autoimmune thyroiditis (AIT) associated with gastroesophageal reflux disease (GERD). Materials and methods. The study was conducted in two groups of patients homogeneous by gender and age. The first group included 42 patients with an isolated AIT and the second group – 120 patients with a comorbid course of AIT and GERD. The contingent of the surveyed was students. Median age was from 18 to 25 years: 23.1±1.2 years in group with isolated AIT and 21.9±2.7 years in group with combined pathology. The activity of caspase-1 was determined using “Elabscience” kits, USA (China) by immunoassay method. The content of IL-18 was investigated using commercial kits “Bender MedSystems GmbH” (Austria) according to the proposed methods by immunoassay method. Statistical data processing was carried out using the local universal software package Statistica Basic Academic 13 for Windows En Local. Methods of non-parametric statistics were used: Kruskal-Wallis test, median test, Mann-Whitney test. Results. It has been found that caspase-1 is activated in patients both in the isolated course of AIT and in its combination with GERD. At the same time, a significant increasing in the synthesis of IL-18 was established, which has pro-inflammatory and autoimmune effects. Re-examination after 2 months of caspase-1 and IL-18 in examined persons determined decreasing their levels, but control results were not achieved. Conclusion. In young patients, the combination of GERD and AIT, as well as an isolated AIT is accompanied by an increasing the levels of caspase-1 and IL-18 in blood serum related to inflammatory process in the thyroid gland and esophageal mucosa with autoimmune component. These biomarkers may reflect the severity of clinical course of diseases and serve as prognostic indicator of outcome in case of comorbidity.

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Alcohol accumulation promotes esophagitis via pyroptosis activation

Cited by 36 publications

References 68 publications

Pyroptosis: mechanisms and diseases

Pyroptosis: mechanisms and diseases

Pyroptosis, a new bridge to tumor immunity

Caspase-Dependent Activation of Cascade Cytokines in Young Patients With Autoimmune Thyroiditis in Combination With Gastroesophageal Reflux Disease

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