Alcohol abuse — A persistent preventable risk for congenital anomalies

Baumann, P.; Schild, Christiane; Hume, Roderick F.; Sokol, Robert J.

doi:10.1016/j.ijgo.2006.05.033

Cited by 16 publications

(11 citation statements)

References 11 publications

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“…Existe un hecho que se ha estudiado y comunicado y es la relación que existe entre hábitos de vida de las madres, como consumo de alcohol, drogas y tabaco y la aparición de MFC en sus hijos [11][12][13][14][15] .…”

Section: Discussionunclassified

Prevalencia al nacimiento de malformaciones congénitas en hijos de madres adolescentes. Hospital Clínico Universidad de Chile: Período 2002-2011

2013

Rev. méd. Chile

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Section: Discussionunclassified

Prevalencia al nacimiento de malformaciones congénitas en hijos de madres adolescentes. Hospital Clínico Universidad de Chile: Período 2002-2011

2013

Rev. méd. Chile

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“…Epidemiological studies have reported a significant increase in the number of congenital abnormalities of the respiratory tract in children born to women who had abused alcohol during pregnancy (4). Studies in rodents have also shown that exposure to high levels of ethanol in midgestation (41) or throughout pregnancy (23) decreases fetal lung growth.…”

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confidence: 99%

Effects of prenatal ethanol exposure on the lungs of postnatal lambs

Sozo

Vela

Stokes

et al. 2011

American Journal of Physiology-Lung Cellular and Molecular Phys

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Prenatal ethanol exposure increases collagen deposition and alters surfactant protein (SP) expression and immune status in lungs of near-term fetal sheep. Our objectives were to determine 1) whether these prenatal effects of repeated gestational ethanol exposure persist after birth and 2) whether surfactant phospholipid composition is altered following prenatal ethanol exposure. Pregnant ewes were chronically catheterized at 90 days of gestational age (DGA) and given a 1-h daily infusion of ethanol (0.75 g/kg, n = 9) or saline (n = 7) from 95 to 135 DGA; ethanol administration ceased after 135 DGA. Lambs were born naturally at full term (146 ± 0.5 DGA). Lung tissue was examined at 9 wk postnatal age for alterations in structure, SP expression, and inflammation; bronchoalveolar lavage fluid was examined for alterations in surfactant phospholipid composition. At 134 DGA, surfactant phospholipid concentration in amniotic fluid was significantly reduced (P < 0.05) by ethanol exposure, and the composition was altered. In postnatal lambs, there were no significant differences between treatment groups in birth weight, postnatal growth, blood gas parameters, and lung weight, volume, tissue fraction, mean linear intercept, collagen content, proinflammatory cytokine gene expression, and bronchoalveolar lavage fluid surfactant phospholipid composition. Although SP-A, SP-B, and SP-C mRNA levels were not significantly different between treatment groups, SP-D mRNA levels were significantly greater (P < 0.05) in ethanol-treated animals; as SP-D has immunomodulatory roles, innate immunity may be altered. The adverse effects of daily ethanol exposure during late gestation on the fetal lung do not persist to 2 mo after birth, indicating that the developing lung is capable of repair.

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“…Existen numerosas publicaciones que demuestran la importancia que tienen como factores de riesgo para MFC, el consumo de alcohol, tabaco y drogas (24)(25)(26)(27).…”

Section: Discussionunclassified

Prevalencia de malformaciones congénitas en hijos de madres mayores de 34 años y adolescentes: Hospital Clínico de la Universidad de Chile, 2002-2011

Herrera

Ovalle

2013

Rev. chil. obstet. ginecol.

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Alcohol abuse — A persistent preventable risk for congenital anomalies

Cited by 16 publications

References 11 publications

Prevalencia al nacimiento de malformaciones congénitas en hijos de madres adolescentes. Hospital Clínico Universidad de Chile: Período 2002-2011

Prevalencia al nacimiento de malformaciones congénitas en hijos de madres adolescentes. Hospital Clínico Universidad de Chile: Período 2002-2011

Effects of prenatal ethanol exposure on the lungs of postnatal lambs

Prevalencia de malformaciones congénitas en hijos de madres mayores de 34 años y adolescentes: Hospital Clínico de la Universidad de Chile, 2002-2011

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