ALCAM Regulates Mediolateral Retinotopic Mapping in the Superior Colliculus

Buhusi, Mona; Demyanenko, Galina P.; Jannie, Karry M.; Dalal, Jasbir S.; Darnell, Eli P.; Weiner, Joshua A.; Maness, Patricia F.

doi:10.1523/jneurosci.2215-09.2009

Cited by 44 publications

(61 citation statements)

References 47 publications

(101 reference statements)

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“…These experiments, moreover, show that this preference is mediated by homophilic ALCAM trans-interactions and not by heterophilic ones (DeBernardo and Chang, 1996;Buhusi et al, 2009). ALCAM trans-interactions, which are only possible in the growth cone subregion situated on the ALCAM-presenting lane, might result in clustering, activation, ubiquitylation, endocytosis and degradation of ALCAM (Thelen et al, 2008), as well as its local translation and membrane insertion.…”

Section: Role Of a Physiological Alcam Level In The Growth Cone Plasmmentioning

confidence: 78%

“…Translation of ALCAM in growth cones also conceivably makes a rapid stop of this local synthesis possible, because no signal has to be sent to the soma to stop ALCAM production and no axonal pool of (just transported) ALCAM has to be dealt with. RGC growth cones on their way to the mesencephalon might immediately cease ALCAM translation upon contact with the chiasm, as growing RGC axons cease to display ALCAM (in contrast to CAML1) after passing the chiasm (Pollerberg and Mack, 1994;Buhusi et al, 2009), which might be of crucial importance for their path and target finding capability.…”

Section: Discussionmentioning

confidence: 99%

“…ALCAM interacts homophilically, i.e. with itself (Tanaka et al, 1991;van Kempen et al, 2001), and heterophilically with the IgSF-CAM CAML1 (also known as NgCAM) (DeBernardo and Chang, 1996;Buhusi et al, 2009). ALCAM is an integral membrane protein, which is ubiquitinated, rapidly endocytosed [in a manner dependent on clathrin or extracellular-signal-regulated kinase (ERK)] and delivered to the degradation pathway; this does not cause, however, changes in the level of ALCAM in the growth cone plasma membrane (Thelen et al, 2008).…”

Section: Introductionmentioning

confidence: 99%

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Translation of the cell adhesion molecule ALCAM in axonal growth cones – regulation and functional importance

Thelen

Maier

Faber

et al. 2012

Journal of Cell Science

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Summary ALCAM is a cell adhesion molecule that is present on extending axons and has been shown to be crucial for elongation and navigation of retinal ganglion cell (RGC) axons. In the present study, we show that ALCAM mRNA is present in axonal growth cones of RGCs in vivo and in vitro, and that translation of ALCAM occurs in RGC growth cones separated from their soma. This growth cone translation is regulated by the 39-untranslated region (39-UTR) of ALCAM and depends on the activity of the kinases ERK and TOR (target of rapamycin). We also investigated the impact of the growth cone translation of ALCAM on axonal functions. Growth cone translation of ALCAM is crucial for the enhanced elongation of axons extending in contact with ALCAM protein. The local translation of ALCAM in the growth cone is able to rapidly counterbalance experimentally induced ALCAM internalization, thereby contributing to the maintenance of constant ALCAM levels in the plasma membrane. Assays where RGC axons have the choice to grow on laminin or both ALCAM and laminin -as is the case in the developing retina -reveal that the axonal preference for ALCAM-containing lanes depends on translation of ALCAM in growth cones. Taken together, these results show for the first time that translation of a cell adhesion molecule in growth cones, as well as the impact of this local translation on the behavior of axon and growth cone.

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Section: Role Of a Physiological Alcam Level In The Growth Cone Plasmmentioning

confidence: 78%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Translation of the cell adhesion molecule ALCAM in axonal growth cones – regulation and functional importance

Thelen

Maier

Faber

et al. 2012

Journal of Cell Science

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“…Interestingly, it functions as a positive or negative predictor or proliferative marker, depending on the underlying background tissue [12,13]. It plays an important role in the growth and extension of neurites [14], hematopoiesis, and in the immune response [15,16]. ALCAM is a highly conserved 110 kDa multidomain transmembrane type 1 glycoprotein of the immunoglobulin superfamily and mediates homotypic and heterotypic interactions between cells [12].…”

Section: Introductionmentioning

confidence: 99%

ALCAM (CD166) Expression as Novel Prognostic Biomarker for Pancreatic Neuroendocrine Tumor Patients

Tachezy

Zander

Marx

et al. 2011

Journal of Surgical Research

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“…2004; DeBernardo and Chang 1995; Ott et al . 2001; Pollerberg and Mack 1994) and is involved in axonal guidance and mapping (Buhusi et al . 2009; Ott et al .…”

Section: Protein Functionmentioning

confidence: 99%