Albuterol and Exercise Effects on Ankle Extensor Strength during 40 Days of Unloading

Caruso, John F.; Hamill, John L.; Yamauchi, Miki; Cook, Tim; Mercado, Dean R.; Wickel, Eric E.

doi:10.3357/asem.2231.2008

Cited by 10 publications

(16 citation statements)

References 26 publications

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“…There is also evidence that women may have greater benefits when using this combined intervention compared with men as evidenced by increased total work and power during exercise sessions. The difference has been hypothesized to occur because of enhanced myofibril sensitivity for calcium in women (Caruso et al 2008). Overall, by coupling this pharmacological agent with resistance exercise, multiple systems are targeted and potentially protected from the negative alterations associated with unloading.…”

Section: Exercise Countermeasuresmentioning

confidence: 99%

Unilateral lower limb suspension: integrative physiological knowledge from the past 20 years (1991–2011)

Hackney

Ploutz‐Snyder

2011

Eur J Appl Physiol

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In 1991, Hans Berg and colleagues published the first research investigation using unilateral lower limb suspension (ULLS) as a human model to study the influence of unloading on skeletal muscle. ULLS requires a participant to perform all activities with axillary crutches while wearing one thick-soled shoe. The elevated shoe eliminates ground contact with the adjacent foot, thereby unloading the lower limb. Today, ULLS is a well-known ground-based analog for microgravity. The present review will synthesize the physiological findings from investigations using ULLS to study the deleterious effects of unloading. Compromised human performance and the neuromuscular, musculoskeletal and circulatory mechanisms leading to altered function will be a major emphasis of the work. Results from prolonged bed rest will also be included in order for general comparisons to be made between analogs. Finally, the efficacy of exercise to mitigate the negative consequences of unloading is presented.

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Section: Exercise Countermeasuresmentioning

confidence: 99%

Unilateral lower limb suspension: integrative physiological knowledge from the past 20 years (1991–2011)

Hackney

Ploutz‐Snyder

2011

Eur J Appl Physiol

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“…Greater losses generally occur with longer flights, with the rate of strength loss exceeding that for muscle atrophy (7,16). The stimulus for in-flight knee extensor losses is a lack of mechanical loading (16).…”

Section: Introductionmentioning

confidence: 99%

“…The merits of FERG workouts were assessed in ambulatory and ground-based microgravity simulation models (7)(8)(9)(10). In addition, the FERG was examined for its utility in Earthbound applications, such as to abate musculoskeletal losses in the elderly (6).…”

Section: Introductionmentioning

confidence: 99%

Blood Lactate and Hormonal Responses to Prototype Flywheel Ergometer Workouts

Caruso

Coday²,

Monda³

et al. 2010

Journal of Strength and Conditioning Research

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The purpose of the study was to compare blood lactate and hormonal responses with flywheel ergometer (FERG) leg presses for preliminary assessment of workouts best suited for future in-flight resistance exercise. Comprised of 10 repetition sets, the workouts entailed 3 sets of concentric and eccentric (CE3) actions, or concentric-only actions done for 3 (CO3) or 6 (CO6) sets. Methods employed included assessment of blood lactate concentrations ([BLa-]) before and 5 minutes postexercise. Venous blood was also collected before and at 1 and 30 minutes postexercise to assess growth hormone, testosterone, cortisol concentrations ([GH], [T], [C]) and [T/C] ratios. [BLa-] were compared with 2 (time) x 3 (workout) analysis of variance. Hormones were assessed with 2 (gender) x 3 (time) x 3 (workout) analysis of covariances. Results showed [BLa-] had a time effect. Growth hormone concentration showed gender x workout, gender x time, and workout x time interactions, whereas [T] had a 3-way interaction. [C] had gender, time, and workout effects. [T/C] yielded a gender x time interaction. It was concluded that, because CO6 and CE3 yielded similar anabolic hormonal data but the latter had a lower [C] 30 minutes postexercise, CE3 served as the best workout. Although the FERG was originally designed for microgravity, the effort put forth by current subjects was like that for workouts aimed at greater athletic performance and conditioning. Practical applications suggest that eccentric actions should be used for FERG workouts geared toward muscle mass and strength improvement.

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“…Caruso et al. [201], however, presented a positive effect on performance by oral administration of salbutamol or albuterol [202]. Similarly, another study showed that a single oral dose of salbutamol increased isokinetic muscle strength and endurance performance in healthy male volunteers [203].…”

Section: Beta‐2 Adrenergic Agonistsmentioning

confidence: 99%

“…In humans, little evidence exists for increase in physical performance after inhalation of salbutamol [196,197], salmeterol [198], formoterol [199], or terbutaline [200]. Caruso et al [201], however, presented a positive effect on performance by oral administration of salbutamol or albuterol [202]. Similarly, another study showed that a single oral dose of salbutamol increased isokinetic muscle strength and endurance performance in healthy male volunteers [203].…”

Section: B E T a -2 A D R E N E R G I C A G O N I S T Smentioning

confidence: 99%

Doping and musculoskeletal system: short‐term and long‐lasting effects of doping agents

Nikolopoulos

Spiliopoulou

Theocharis

2010

Fundamemntal Clinical Pharma

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Doping is a problem that has plagued the world of competition and sports for ages. Even before the dawn of Olympic history in ancient Greece, competitors have looked for artificial means to improve athletic performance. Since ancient times, athletes have attempted to gain an unfair competitive advantage through the use of doping substances. A Prohibited List of doping substances and methods banned in sports is published yearly by the World Anti-Doping Agency. Among the substances included are steroidal and peptide hormones and their modulators, stimulants, glucocorticosteroids, β₂-agonists, diuretics and masking agents, narcotics, and cannabinoids. Blood doping, tampering, infusions, and gene doping are examples of prohibited methods indicated on the List. Apart from the unethical aspect of doping, as it abrogates fair-play's principle, it is extremely important to consider the hazards it presents to the health and well-being of athletes. The referred negative effects for the athlete's health have to do, on the one hand, by the high doses of the performance-enhancing agents and on the other hand, by the relentless, superhuman strict training that the elite or amateur athletes put their muscles, bones, and joints. The purpose of this article is to highlight the early and the long-lasting consequences of the doping abuse on bone and muscle metabolism.

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Albuterol and Exercise Effects on Ankle Extensor Strength during 40 Days of Unloading

Cited by 10 publications

References 26 publications

Unilateral lower limb suspension: integrative physiological knowledge from the past 20 years (1991–2011)

Unilateral lower limb suspension: integrative physiological knowledge from the past 20 years (1991–2011)

Blood Lactate and Hormonal Responses to Prototype Flywheel Ergometer Workouts

Doping and musculoskeletal system: short‐term and long‐lasting effects of doping agents

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