Albuminuria Independently Determines Intact Parathyroid Hormone in Diabetic Nephropathy with Micro-albuminuria

Gameil, Mohammed Ali; Marzouk, Rehab Elsayed; Elsebaie, Ahmed Hassan; Eldeeb, Ahmed

doi:10.21608/ejhm.2021.180351

Cited by 1 publication

(2 citation statements)

References 9 publications

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“…After a full‐text assessment for eligibility, 141 articles were excluded. Ultimately, 23 articles were included in the meta‐analysis, 10–32 as shown in the PRISMA 33 (Figure 1).…”

Section: Resultsmentioning

confidence: 99%

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Progression of diabetic nephropathy and vitamin D serum levels: A pooled analysis of 7722 patients

Dean,

Elawady,

Shi

et al. 2023

Endocrino Diabet & Metabol

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Background and AimLow serum Vitamin D levels have been associated with diabetic nephropathy (DN). Our study aimed to analyse the serum levels of vitamin D in patients suffering from DN and the subsequent changes in serum vitamin D levels as the disease progresses.MethodsPubMed, Embase, SCOPUS and Web of Science were searched using keywords such as ‘25 hydroxyvitamin D’ and ‘diabetic nephropathy’. We included observational studies that reported the association between the serum 25 hydroxy vitamin D levels and diabetic nephropathy without restriction to age, gender, and location. R Version 4.1.2 was used to perform the meta‐analysis. The continuous outcomes were represented as mean difference (MD) and standard deviation (SD) and dichotomous outcomes as risk ratios (RR) with their 95% confidence interval (CI).ResultsTwenty‐three studies were included in our analysis with 7722 patients. Our analysis revealed that vitamin D was significantly lower in diabetic patients with nephropathy than those without nephropathy (MD: −4.32, 95% CI: 7.91–0.74, p‐value = .0228). On comparing diabetic patients suffering from normoalbuminuria, microalbuminuria, or macroalbuminuria, we found a significant difference in serum vitamin D levels across different groups. Normoalbuminuria versus microalbuminuria showed a MD of −1.69 (95% CI: −2.28 to −1.10, p‐value = .0002), while microalbuminuria versus macroalbuminuria showed a MD of (3.75, 95% CI: 1.43–6.06, p‐value = .0058), proving that serum vitamin D levels keep declining as the disease progresses. Notwithstanding, we detected an insignificant association between Grade 4 and Grade 5 DN (MD: 2.29, 95% CI: −2.69–7.28, p‐value = .1862).ConclusionSerum Vitamin D levels are lower among DN patients and keep declining as the disease progresses, suggesting its potential benefit as a prognostic marker. However, on reaching the macroalbuminuria stage (Grades 4 and 5), vitamin D is no longer a discriminating factor.

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“…After a full‐text assessment for eligibility, 141 articles were excluded. Ultimately, 23 articles were included in the meta‐analysis, 10–32 as shown in the PRISMA 33 (Figure 1).…”

Section: Resultsmentioning

confidence: 99%

“…After a full‐text assessment for eligibility, 141 articles were excluded. Ultimately, 23 articles were included in the meta‐analysis, 10 , 11 , 12 , 13 , 14 , 15 , 16 , 17 , 18 , 19 , 20 , 21 , 22 , 23 , 24 , 25 , 26 , 27 , 28 , 29 , 30 , 31 , 32 as shown in the PRISMA 33 (Figure 1 ).…”

Section: Resultsmentioning

confidence: 99%