Albuminuria, Disease Duration, and Glycated Hemoglobin Are Related With Bone Mineral Density in Type 1 Diabetes: A Cross-sectional Study

López-Prieto, Rossy S.; Reza-Albarrán, Alfredo; Clark, Patricia C.; Díaz, Rita Angélica Gómez; Aguilera-Ruvalcaba, Miguel S.; Güereca-Olguín, Diana C.; Jalife-Velázquez, Grecia Q.; Soto-Mota, Adrián; Viveros-Ruiz, Tannia Leticia; Juárez-Martínez, Liliana; Gómez-Pérez, Francisco J.; Almeda‐Valdés, Paloma

doi:10.1016/j.eprac.2023.02.005

Cited by 2 publications

(2 citation statements)

References 11 publications

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“…Glycated hemoglobin (HbA1c) is one of the main indicators of glycemic control and is strongly correlated with risks of long-term complications [ 17 , 19 , 20 , 21 ].…”

Section: Introductionmentioning

confidence: 99%

The Influence of Body Fat and Lean Mass on HbA1c and Lipid Profile in Children and Adolescents with Type 1 Diabetes Mellitus

Menegucci,

Chagas,

de Oliveira Zanuso

et al. 2023

Diseases

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Glycated hemoglobin (HbA1c) is used to assess glycemic control in Type 1 diabetes (DM1) patients. Apolipoproteins play an essential role in DM1 pathophysiology and may be associated with complications and HbA1c. This cross-sectional observational study of 81 children and adolescents of both sexes diagnosed with DM1 investigated the relationship between body fat distribution and lean mass with HbA1C and apolipoprotein values, analyzing biochemical and body composition measurements. A Shapiro–Wilk test with Lilliefors correction, a non-parametric Mann–Whitney test, and others were used with a significance level of 5%. The sample had a diagnosis time of 4.32 years and high blood glucose levels (mean 178.19 mg/dL) and HbA1c (mean 8.57%). Subjects also had a moderate level of adiposity, as indicated by arm and thigh fat areas. The study also found significant differences in the distribution of patients concerning levels of apolipoproteins A and B, with a smaller proportion of patients having undesirable levels. Finally, the study found a significant difference in the distribution of patients with estimated cardiovascular risk based on the ApoB/ApoA-I ratio. Conclusively, visceral fat in children and adolescents with DM1 may increase the risk of DM1 long-term complications owing to its association with elevated HbA1C and apolipoprotein values.

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“…Glycated hemoglobin (HbA1c) is one of the main indicators of glycemic control and is strongly correlated with risks of long-term complications [ 17 , 19 , 20 , 21 ].…”

Section: Introductionmentioning

confidence: 99%

The Influence of Body Fat and Lean Mass on HbA1c and Lipid Profile in Children and Adolescents with Type 1 Diabetes Mellitus

Menegucci,

Chagas,

de Oliveira Zanuso

et al. 2023

Diseases

View full text Add to dashboard Cite

show abstract

“…However, this association has not been observed in men [ 10 , 11 ]. On the other hand, López-Prieto et al [ 12 ] observed a positive association between elevated serum levels of HbA1c and diminished bone mineral density (BMD) specifically in the lumbar region of the spine. This correlation maintained its statistical significance even when accounting for variables such as age, gender, and body mass index (BMI)1.…”

Section: Introductionmentioning

confidence: 99%

Differential Association of Glycation Products with Bone Mineral Density and Fat Mass in Healthy and Diabetes Type 2 Subjects from Mexican Southeastern: A Cross Sectional Study

Ferreyro-Bravo,

Ceballos-Cruz,

Urruchua-Rodríguez

et al. 2023

Medicina

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Background: Glycation products have been linked to decreased bone mineral density (BMD) in a number of clinical settings. This study examined the correlation between early glycation products (HbA1c and glycated albumin (ALB-g)) and advanced glycation end products (pentosidine (PTD)) with BMD in two groups of participants: those with type 2 diabetes mellitus (DM2) and those without diabetes or any other comorbidities (noDM). All of the participants had resided in southeastern Mexico for a minimum of 10 years. Material and Methods: This study included 204 participants: 112 (55%) with DM2 and 92 (45%) healthy subjects. We utilized dual X-ray absorptiometry (DXA) to measure both the total and segment-specific BMD and adipose mass. In addition, the fasting blood glucose, HbA1c, PTD, and ALB-g parameters were measured. Correlation and logistic regression analyses were conducted. Results: There was an inverse correlation between PTD and BMD in all anatomical regions among postmenopausal women (PMW) in the DM2 group, whereas in non-PMW, only the waist-to-height ratio was statistically significant. A negative correlation was observed between HbA1c levels and BMD in the arms and legs of DM2 individuals. However, in the noDM group, a negative correlation was found between HbA1c levels and BMD in the pelvis, while a positive association was observed between HbA1c and indicators of adipose tissue. ALB-g, demonstrated a negative correlation with fat mass. After performing binary logistic regressions, the following odds ratios (OR) for osteopenia/osteoporosis risk were determined: PTD OR 1.1 (p = 0.047) for DM2 PMW, HbA1c OR 1.4 (p = 0.048), and fat mass content OR 1.011 (p = 0.023) for the entire sample. Conclusions: Glycation products are associated with BMD differentially depending on the analyzed anatomical segment, but PTD, HbA1c, and fat mass are significant predictors of low bone mass. In prospective studies, this association could be determined using other techniques involving three-dimensional analysis of bone architecture to evaluate bone architecture.

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Albuminuria, Disease Duration, and Glycated Hemoglobin Are Related With Bone Mineral Density in Type 1 Diabetes: A Cross-sectional Study

Cited by 2 publications

References 11 publications

The Influence of Body Fat and Lean Mass on HbA1c and Lipid Profile in Children and Adolescents with Type 1 Diabetes Mellitus

The Influence of Body Fat and Lean Mass on HbA1c and Lipid Profile in Children and Adolescents with Type 1 Diabetes Mellitus

Differential Association of Glycation Products with Bone Mineral Density and Fat Mass in Healthy and Diabetes Type 2 Subjects from Mexican Southeastern: A Cross Sectional Study

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