Albumin Products

Finlayson, J. S.

doi:10.1055/s-2007-1005097

Cited by 27 publications

(23 citation statements)

References 108 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Apart from aggregates or the role of stabilizers, the possible activation of the kallikrein-kinin system has to be considered. Kinin activating substances have been found in HSA prep arations [1] and brought into context with pseudoallergic reactions manifesting mainly as hypotension [3,7]. Whether altered binding characteristics of drugs or endogenous metabolites (e.g.…”

Section: Discussionmentioning

confidence: 99%

“…Human serum albumin (HSA) is widely used in clinical medicine for various indications (volume sub stitution, treatment of oncotic pressure deficits, acute hypoproteinemia, detoxification and plasmapheresis) [7,10,13,15,25], Incompatibility reactions to HSA are rare, but life-threatening reactions have been re ported [4,16,17,19,25]. The pathomechanism of pseu do-allergic reactions to HSA is by no means clear.…”

Section: Introductionmentioning

confidence: 99%

“…Then HSA is heated for 10 h at 60°C in order to inactivate possible contaminating viruses [7], Dur ing this heat treatment various stabilizing agents are added, the most commonly used are sodium caprylate and sodium N-acetyl-DL-tryptophane [9]. Some years ago Schneider et al [26] proposed a new albumin frac tionation procedure using a heat ethanol precipita- ' The excellent technical assistance of Miss Franziska Beier is gratefully acknowledged.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

In vitro Studies Involving Histamine and Lysosomal Enzyme Release from Human Peripheral Leukocytes with Different Human Serum Albumin (HSA) Preparations

Ring¹

1984

Int Arch Allergy Immunol

View full text Add to dashboard Cite

Various batches of differently prepared human serum albumin (HSA) were tested for their capacity to induce in vitro release of histamine or lysosomal enzymes from peripheral human leucocytes. While there was little effect of most of the native preparations tested, some batches showed significant release of histamine or lysosomal enzymes after heating to 70 °C. HSA preparations produced by heat ethanol fractionation never induced significant release reactions. It is concluded that the mode of production and the selection of stabilizing agents might influence reactions of HSA with mediator-secreting cells.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

In vitro Studies Involving Histamine and Lysosomal Enzyme Release from Human Peripheral Leukocytes with Different Human Serum Albumin (HSA) Preparations

Ring¹

1984

Int Arch Allergy Immunol

View full text Add to dashboard Cite

show abstract

“…The ethanol is then removed by ultracentrifugation or freeze-drying. 21 After the albumin has been purified and within 24 hours of being placed in the final container, the product is heated to 60 ± 0.5°C for 10 to 11 hours. 1 This inactivates a variety of viruses, including HBV and HIV.…”

Section: Cold Ethanol Fractionationmentioning

confidence: 99%

Albumin

Culler¹,

Lögdberg²

2007

Blood Banking and Transfusion Medicine

View full text Add to dashboard Cite

“…In the 1940s it was the first human blood proteins to be mass-produced by plasma fractionation and was used on the battlefields and in military hospitals as a blood replacement product (Finlayson 1980;Peters 1996). Following World War II the therapeutic uses of hSA increased substantially to include critically ill patients with numerous acute and chronic conditions (Hennessen 1980;Alexander et al 1982;Erstad et al 1991;Wilkes and Navickis 2001).…”

Section: Introductionmentioning

confidence: 99%

Production of recombinant albumin by a herd of cloned transgenic cattle

Echelard¹,

Williams²,

Destrempes³

et al. 2008

Transgenic Res

View full text Add to dashboard Cite

Purified plasma derived human albumin has been available as a therapeutic product since World War II. However, cost effective recombinant production of albumin has been challenging due to the amount needed and the complex folding pattern of the protein. In an effort to provide an abundant source of recombinant albumin, a herd of transgenic cows expressing high levels of rhA in their milk was generated. Expression cassettes efficiently targeting the secretion of human albumin to the lactating mammary gland were obtained and tested in transgenic mice. A high expressing transgene was transfected in primary bovine cell lines to produce karyoplasts for use in a somatic cell nuclear transfer program. Founder transgenic cows were produced from four independent cell lines. Expression levels varying from 1-2 g/l to more than 40 g/l of correctly folded albumin were observed. The animals expressing the highest levels of rhA exhibited shortened lactation whereas cows yielding 1-2 g/l had normal milk production. This herd of transgenic cattle is an easily scalable and well characterized source of rhA for biomedical uses.

show abstract

Albumin Products

Cited by 27 publications

References 108 publications

In vitro Studies Involving Histamine and Lysosomal Enzyme Release from Human Peripheral Leukocytes with Different Human Serum Albumin (HSA) Preparations

In vitro Studies Involving Histamine and Lysosomal Enzyme Release from Human Peripheral Leukocytes with Different Human Serum Albumin (HSA) Preparations

Albumin

Production of recombinant albumin by a herd of cloned transgenic cattle

Contact Info

Product

Resources

About