Albumin Nanoparticles for the Intravitreal Delivery of Anticytomegaloviral Drugs

Irache, Juan Manuel; Merodio, Marta; Arnedo, A; Camapanero, M. A.; Mirshahi, Massoud; Espuelas, Socorro

doi:10.2174/1389557053175335

Cited by 113 publications

(64 citation statements)

References 80 publications

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“…Specifically, due to their high content of charged amino acids (for example, lysine, arginine, glutamate and aspartate), albumin-based NPs are capable of loading either positively or negatively charged molecules by electrostatic forces without the addition of other accessory compounds. 58,59 Second, their surface properties are well tolerated by charged polymers, which broaden the application of albumin NPs in biomedical areas. Third, albumin-based NPs are biodegradable, easy to fabricate, and reproducible under mild conditions by desolvation (coacervation), 60 emulsification, 61 and selfassembly techniques.…”

Section: Protein-based Nps For Gf Deliverymentioning

confidence: 99%

Novel biomaterial strategies for controlled growth factor delivery for biomedical applications

et al. 2017

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Growth factors (GFs) are soluble proteins secreted by cells that have the ability to regulate a variety of cellular processes and tissue regeneration. However, their translation into clinical applications is limited due to their short effective half-life, low stability, and rapid inactivation by enzymes under physiological conditions. To maximize the effectiveness of GFs and their biologically relevant applicability, a wide variety of sophisticated bio-inspired systems have been developed that augment tissue repair and cellular regeneration by controlling how much, when, and where GFs are released. Recently, protein immobilization techniques combined with nanomaterial carriers have shown promise in mimicking the natural healing cascade during tissue regeneration by augmenting the delivery and effectiveness of GFs. This review evaluates the latest techniques in direct immobilization and relevant biomaterials used for GF loading and release, including synthetic polymers, albumin, polysaccharides, lipids, mesoporous silica-based nanoparticles (NPs), and polymeric capsules. Specifically, we focus on GF-encapsulated NPs in functionalized microporous scaffolds as a promising alternative with the ability to mimic extracellular matrix (ECM) hierarchical architectures and components with high cell affinity and bioactivity. Finally, we discuss how these next-generation, advanced delivery systems have been used to enhance tissue repair and regeneration and consider future implications for their use in the field of regenerative medicine.

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Section: Protein-based Nps For Gf Deliverymentioning

confidence: 99%

Novel biomaterial strategies for controlled growth factor delivery for biomedical applications

et al. 2017

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“…The NPs are found to be promising candidates in PDD [42] as their size can modulate with respect to different formulation methods and parameters. The variability in particle size helps to target different sites in the lungs.…”

Section: Need Of Pdd Of Nps Containing Atdsmentioning

confidence: 99%

Drug-Resistant Tuberculosis: Recent Approach in Polymer Based Nanomedicine

Shaji

Shaikh

2016

Int J Pharm Pharm Sci

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Tuberculosis (TB) had been a leading chronic bacterial infection since decades. Current therapeutic management of Mycobacterium tuberculosis (MTB) is inadequate due to the lengthy course of treatment, drug-related side effects and ill-planned therapy, and these factors can lead to therapeutic failure and the emergence of drug-resistant TB. The Multi-drug-resistant (MDR) TB needs a lengthy course of treatment with secondline antitubercular drugs (ATDs) having higher side effects and cost. The misuse of second-line ATDs may result in extremely drug-resistant (XDR) strain which is very difficult to treat and require high doses of drugs resulting in more toxicity and side effects. This review highlights the need for novel drug delivery for the treatment of drug-susceptible and resistant TB. The characteristics of the nanoparticulate system in ATDs delivery and its approach in the MDR and XDR TB are discussed. The lung is the site of infection in pulmonary TB and the targeted drug delivery to the site of infection helps in achieving increased efficacy with less dose further reducing the side effects and toxicity. The symbiotic association of nanotechnology and pulmonary drug delivery give rise to an efficient inhalable polymer based nanoparticulate system containing ATDs for the better management of drug-susceptible and resistant TB. Various ATDs loaded polymer based nanocarrier systems like Alginate, PLGA, Chitosan and Gelatin nanocarriers are discussed in detail. Thus, this review highlights the current research in pulmonary drug delivery of polymer based ATDs nanomedicine and their importance in control of drug-resistant TB.

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“…Due to define primary structure and high content of charged amino acid residues, albumin-based nanoparticles could allow for the electrostatic adsorption of positivelyand negatively-charged molecules without the requirement of other compounds. 44,45 Apart from this, they can be easily prepared under normal environmental conditions by various methods like coacervation, controlled desolvation, and emulsification. In addition, albumin nanoparticles are well …”

Section: Protein Nanoparticle and Their Conjugatesmentioning

confidence: 99%

Nanoparticles in relation to peptide and protein aggregation

Zaman

Ahmad

Qadeer

et al. 2014

IJN

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Over the past two decades, there has been considerable research interest in the use of nanoparticles in the study of protein and peptide aggregation, and of amyloid-related diseases. The influence of nanoparticles on amyloid formation yields great interest due to its small size and high surface area-to-volume ratio. Targeting nucleation kinetics by nanoparticles is one of the most searched for ways to control or induce this phenomenon. The observed effect of nanoparticles on the nucleation phase is determined by particle composition, as well as the amount and nature of the particle’s surface. Various thermodynamic parameters influence the interaction of proteins and nanoparticles in the solution, and regulate the protein assembly into fibrils, as well as the disaggregation of preformed fibrils. Metals, organic particles, inorganic particles, amino acids, peptides, proteins, and so on are more suitable candidates for nanoparticle formulation. In the present review, we attempt to explore the effects of nanoparticles on protein and peptide fibrillation processes from both perspectives (ie, as inducers and inhibitors on nucleation kinetics and in the disaggregation of preformed fibrils). Their formulation and characterization by different techniques have been also addressed, along with their toxicological effects, both in vivo and in vitro.

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Albumin Nanoparticles for the Intravitreal Delivery of Anticytomegaloviral Drugs

Cited by 113 publications

References 80 publications

Novel biomaterial strategies for controlled growth factor delivery for biomedical applications

Novel biomaterial strategies for controlled growth factor delivery for biomedical applications

Drug-Resistant Tuberculosis: Recent Approach in Polymer Based Nanomedicine

Nanoparticles in relation to peptide and protein aggregation

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