Albumin nanoparticles—A versatile and a safe platform for drug delivery applications

Zwain, Tamara; Taneja, Neetika; Zwayen, Suha; Shidhaye, Aditi; Palshetkar, Aparana; Singh, Kamalinder K.

doi:10.1016/b978-0-12-820757-4.00008-9

Cited by 7 publications

(9 citation statements)

References 132 publications

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“…As a multifunctional protein, albumin becomes an ideal carrier for drug delivery applications due to its abundance, high binding capacity, biodegradability and biocompatibility. 78 Albumin, for example, can be enriched in the target sites as an energy and amino acid source for tumors and inflammatory tissues. Furthermore, albumin possesses multiple functional groups that can be covalently conjugated or just absorbed to the surface of nanoparticles through derivatization techniques.…”

Section: In Vivo Transport Of Albuminmentioning

confidence: 99%

“…2,115 This is attributed to several key advantages, including its excellent biocompatibility, amenability to surface modifications, and wide availability from diverse sources. 78 When administered in conjunction with drug Table 3 molecules, albumin can markedly improve the pharmacokinetic profiles of these drugs. This enhancement is evident in various ways, including the amelioration of water solubility in the case of hydrophobic drugs, protection and stabilization of biomolecule drugs from degradation, and promotion of drug molecule accumulation at the disease sites.…”

Section: Conclusion and Future Perspectivesmentioning

confidence: 99%

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Inflammation-Targeted Drug Delivery Strategies via Albumin-Based Systems

Wu,

Wang,

Chen

et al. 2024

ACS Biomater. Sci. Eng.

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Albumin, being the most abundant serum protein, has the potential to significantly enhance the physicochemical properties of therapeutic payloads, thereby improving their pharmacological effects. Apart from its passive transport via the enhanced permeability and retention effect, albumin can actively accumulate in tumor microenvironments or inflammatory tissues via receptor-mediated processes. This unique property makes albumin a promising scaffold for targeted drug delivery. This review focuses on exploring different delivery strategies that combine albumin with drug payloads to achieve targeted therapy for inflammatory diseases. Also, albumin-derived therapeutic products on the market or undergoing clinical trials in the past decade have been summarized to gain insight into the future development of albumin-based drug delivery systems. Given the involvement of inflammation in numerous diseases, drug delivery systems utilizing albumin demonstrate remarkable advantages, including enhanced properties, improved in vivo behavior and efficacy. Albumin-based drug delivery systems have been demonstrated in clinical trials, while more advanced strategies for improving the capacity of drug delivery systems with the help of albumin remain to be discovered. This could pave the way for biomedical applications in more effective and precise treatments.

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Section: In Vivo Transport Of Albuminmentioning

confidence: 99%

Section: Conclusion and Future Perspectivesmentioning

confidence: 99%

Inflammation-Targeted Drug Delivery Strategies via Albumin-Based Systems

Wu,

Wang,

Chen

et al. 2024

ACS Biomater. Sci. Eng.

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“…Bovine serum albumin (BSA) was chosen as the host material to construct the delivery vehicle. BSA is an abundant plasma protein, and it has been widely studied and applied in the biomedical field without biosafety concerns . The advantages of BSA include excellent biocompatibility, non-immunogenicity, and reliable in vivo stability .…”

Section: Introductionmentioning

confidence: 99%

“…BSA is an abundant plasma protein, and it has been widely studied and applied in the biomedical field without biosafety concerns. 36 The advantages of BSA include excellent biocompatibility, non-immunogenicity, and reliable in vivo stability. 37 In addition, BSA involves many amino and carboxyl groups that are favorable for modification to connect with multitudinous functional modules.…”

Section: Introductionmentioning

confidence: 99%

Leveraging Nanodrug Delivery System for Simultaneously Targeting Tumor Cells and M2 Tumor-Associated Macrophages for Efficient Colon Cancer Therapy

Zeng

Sun

et al. 2022

ACS Appl. Mater. Interfaces

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Tumor-associated macrophages (TAMs) widely exist in the solid tumors, which participate in the entire course of tumor development and execute momentous impacts. Therefore, manipulating TAMs has been identified as an expecting strategy with immense potential for cancer therapy. Herein, a nanodrug delivery system was leveraged for simultaneously targeting tumor cells and M2-type TAMs for efficient colon cancer therapy. The broad-spectrum anticancer chemotherapeutic drug doxorubicin (DOX) was hitchhiked in a mannose-modified bovine serum albumin (MAN-BSA) carrier. The DOX@MAN-BSA nanodrug delivery system was verified to possess feasible physical performances for unhindered systemic circulation and active targeting on colon tumors. DOX@MAN-BSA nanoparticles could be preferentially swallowed by colon tumor cells and M2 TAMs through mannose receptor-mediated endocytosis. Further in vivo antitumor therapy in CT26 colon tumor-bearing mice has achieved remarkable suppression efficacy with satisfactory biosafety. Leveraging the nanodrug delivery system for simultaneously targeting tumor cells and M2 TAMs has contributed a feasible strategy to collaboratively repress the malignant tumor cells and the collusive M2 TAMs for efficient cancer therapy.

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“…Human serum albumin has a half-life of 19 days and is a highly soluble acidic protein. In addition, biodegradability, non-toxicity, non-immunogenicity, appropriate size and long-term circulation are factors that make it an effective drug carrier [ 31 , 32 ]. Albumin plays an important role in the transport of many endogenous and exogenous ligands (such as hormones, FA, nitric oxide, bilirubin, metalloporphyrins, warfarin, aspirin, phenylbutazone, etc.)…”

Section: Introductionmentioning

confidence: 99%

Synthesis of Artemether-Loaded Albumin Nanoparticles and Measurement of Their Anti-Cancer Effects

2022

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Colorectal cancer is the third most common cancer in the world. Due to the side effects of common treatments such as chemotherapy and radiotherapy, the use of herbal medicines has received much attention. Artemether (ARM) is an herbal medicine derived from artemisinin, which has many anti-tumor properties. However, factors such as low solubility and short half-life have limited the use of artemether in clinical practice. In this study, we aimed to reduce these limitations by encapsulating artemether in human serum albumin (HSA). The hydrodynamic diameter and the zeta potential value of ARM-ALB nanoparticles (NPs) were 171.3 ± 5.88 nm and −19.1 ± 0.82 mV, respectively. Comparison of the effect of free and encapsulated artemether on CT 26 cell line showed that the use of artemether in capsulated form can reduce the effective concentration of the drug. Additionally, in vivo studies have also shown that albumin–artemether nanoparticles can control tumor growth by increasing the production of cytokine IFN-γ and decreasing the production of IL4. Therefore, ARM-ALB nanoparticles have greater anti-tumor effects than free artemether.

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Albumin nanoparticles—A versatile and a safe platform for drug delivery applications

Cited by 7 publications

References 132 publications

Inflammation-Targeted Drug Delivery Strategies via Albumin-Based Systems

Inflammation-Targeted Drug Delivery Strategies via Albumin-Based Systems

Leveraging Nanodrug Delivery System for Simultaneously Targeting Tumor Cells and M2 Tumor-Associated Macrophages for Efficient Colon Cancer Therapy

Synthesis of Artemether-Loaded Albumin Nanoparticles and Measurement of Their Anti-Cancer Effects

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