Albumin levels as a predictor of mortality in the healthy elderly

Klonoff-Cohen, Hillary; Barrett‐Connor, Elizabeth; Edelstein, Sharon L.

doi:10.1016/0895-4356(92)90080-7

Cited by 180 publications

(105 citation statements)

References 17 publications

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“…It has been noted that A␤ plaques are only ever observed in the brain and not the peripheral tissue, probably because HSA concentrations are of a much higher magnitude (640 M) in the blood plasma (26). Interestingly, serum albumin levels, in vivo, decrease with age, which is also a known risk factor in AD (30). Furthermore, levels of albumin are often reduced in association with inflammation, also linked with AD.…”

Section: Discussionmentioning

confidence: 99%

Human Serum Albumin Can Regulate Amyloid-β Peptide Fiber Growth in the Brain Interstitium

Stanyon

Viles

2012

Journal of Biological Chemistry

141

124

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Section: Discussionmentioning

confidence: 99%

Human Serum Albumin Can Regulate Amyloid-β Peptide Fiber Growth in the Brain Interstitium

Stanyon

Viles

2012

Journal of Biological Chemistry

141

124

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“…[23][24][25] Low serum albumin may suggest the existence of a subclinical disease or a poor physical condition. 26) Study limitation: The present study has the following limitations: First, since this study was a retrospective analysis at a single center, there may be patient selection bias. Second, since the study population was relatively small, the statistical analysis has an inherent risk of β error.…”

Section: Discussionmentioning

confidence: 99%

Determinants of In-Hospital Death in Acute Myocardial Infarction With Triple Vessel Disease

et al. 2016

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SummaryCompared to acute myocardial infarction (AMI) with single vessel disease (SVD) or double vessel disease (DVD), AMI with triple vessel disease (TVD) is associated with higher mortality. The aim of this study was to identify the determinants of in-hospital death in AMI with TVD. We identified AMI patients with TVD in our tertiary medical center between January 2009 and December 2014. Baseline patient characteristics including laboratory data, echocardiograms, and coronary angiograms were collected from our hospital records. We divided our study population into a survivor group and non-survivor group. Multivariate stepwise logistic regression analysis was performed to identify the determinants of in-hospital death. A total of 138 AMI patients with TVD were identified and included as the final study population. Fifteen patients died during the hospitalization (mortality rate, 10.9%). Mean systolic blood pressure (134 ± 27 mmHg) was significantly greater in the survivor group compared with the non-survivor group (114 ± 31 mmHg) (P = 0.02). The prevalence of shock on admission was significantly less in the survivor group (15.4%) than in the non-survivor group (66.7%) (P < 0.001). Multivariate stepwise logistic regression analysis revealed that shock status on admission (OR 11.50, 95% CI 3.21-41.14, P < 0.001), the left anterior descending artery (LAD) as the infarct related artery (IRA) (OR 3.83, 95% CI 1.04-14.09, P = 0.04), and serum albumin on admission (OR 0.26, 95% CI 0.08-0.84, P = 0.02) were significantly associated with in-hospital death. In conclusion, shock status on admission, the LAD as the IRA, and a low serum albumin level were the determinants of in-hospital death in AMI patients with TVD. ( 1,2) The in-hospital mortality rates of AMI complicated with cardiogenic shock with SVD, DVD, and TVD were reported to be 32.8%, 45.1%, and 58.2%, respectively. 1) Furthermore, the long-term mortality of AMI with TVD is poorer than that with DVD.2) Although several groups studied the determinants of poor clinical outcomes in AMI with multivessel disease, 3,4) the determinants of in-hospital death in AMI with TVD have not been fully investigated. It is clinically important to identify such determinants in order to obtain a better understanding of AMI with TVD, because the mortality of AMI with TVD is the greatest among AMI.

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“…In fact, the day-service centers in Yamato offer lunch, supervised by registered dieticians, and regular snacks in the afternoon. The serum albumin concentration is not only a marker for general nutritional status, but also a marker for predicting various health outcomes such as mortality, functional limitation, muscle strength and disability (Klonoff-Cohen et al 1992;Zuliani et al 2001;Schalk et al 2005a). Moreover, it has been reported that changes in serum albumin concentration, within a normal range, are associated with future functional decline (Schalk et al 2005b).…”

Section: Discussionmentioning

confidence: 99%

The Usefulness of Day-Service in Maintaining General Nutritional Status in Elderly Japanese: A Longitudinal Study

Nishiwaki

Ueno

Hasegawa

et al. 2007

Tohoku J. Exp. Med.

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Day-service, commuting service for elderly people requiring care at home, is one healthcare option in Japan. To date, however, there exist no studies that have examined the effects of day-service use on health outcomes in Japan. The objective of the present longitudinal study was to determine whether there is an association between day-service use and various physical and mental health outcomes in elderly people requiring care. The subjects were 61 elderly persons who required between 25 and 49 min of assistance per day and used long-term care insurance. Measurements included demographic characteristics, activities of daily living, frequency of day-service use, body weight, height, grip strength, thigh muscle volume, degree of depression (Geriatric Depression Scale), the mini-mental state examination, and serum albumin and blood hemoglobin levels in the baseline and follow-up surveys two years later. In the day-service user group, the mean changes in serum albumin concentrations using day-service once, twice and three times/week were −0.2, −0.3, and 0 g/dl, respectively, and the mean changes in blood hemoglobin were −0.7, −0.5, and 0.2 g/dl, respectively. The two-year change in serum albumin concentrations was less ( p = 0.024) in subjects using day-service "three times" (0 g/dl) than "twice" (−0.3 g/dl). The two-year change in blood hemoglobin was also less ( p = 0.043) in subjects using day-service "three times" (0.2 g/dl) than "twice" (−0.5 g/dl). The present study has shown that frequent use of day-service is useful in maintaining general nutritional status in elderly people.albumin; community health services; cohort studies; elderly; hemoglobin © 2007 Tohoku University Medical PressDay-service, commuting service for elderly people requiring care at home, is one healthcare option, administered by local governments throughout Japan. Day-service consists of a number of services, including bathing and meal service (with assistance when needed), consultation,

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Albumin levels as a predictor of mortality in the healthy elderly

Cited by 180 publications

References 17 publications

Human Serum Albumin Can Regulate Amyloid-β Peptide Fiber Growth in the Brain Interstitium

Human Serum Albumin Can Regulate Amyloid-β Peptide Fiber Growth in the Brain Interstitium

Determinants of In-Hospital Death in Acute Myocardial Infarction With Triple Vessel Disease

The Usefulness of Day-Service in Maintaining General Nutritional Status in Elderly Japanese: A Longitudinal Study

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