Albumin knockout mice exhibit reduced plasma free fatty acid concentration and enhanced insulin sensitivity

Abdollahi, Afsoun; Dowden, Brianna; Buhman, Kimberly K.; Zembroski, Alyssa S.; Henderson, Gregory C.

doi:10.14814/phy2.15161

Cited by 13 publications

(24 citation statements)

References 87 publications

(122 reference statements)

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“…However, patients and animals with advanced CKD without nephrosis-range proteinuria also exhibit hypertriglyceridemia and elevated FFA levels [ 34 ], which suggests that increased FFA may be one of the manifestations of renal insufficiency rather than the result of decreased albumin. Indeed, a lack of albumin, which can act as an acceptor and carrier of FFA, may diminish intravascular lipolysis and reduce plasma FFA concentrations [ 37 , 38 ]. Therefore, an increase in FFA level can be used as an independent predictor for AKI in NS patients.…”

Section: Discussionmentioning

confidence: 99%

Serum free fatty acid elevation is related to acute kidney injury in primary nephrotic syndrome

Zhang

Cui

et al. 2022

Renal Failure

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The aim of this research was to examine the clinical characteristics of acute kidney injury (AKI) in primary nephrotic syndrome (NS) and discuss the relationship between serum lipids and AKI. A total of 1028 patients diagnosed with primary NS with renal biopsy results were enrolled in this study. The patients were divided into AKI ( n = 81) and non-AKI ( n = 947) groups, and their characteristics were compared using a propensity score analysis for the best matching. Serum free fatty acid (FFA) was an independent predictor for AKI in the postmatch samples ( p = 0.011). No significant difference in FFA levels was observed among AKI stages or different pathological types in the AKI and non-AKI groups. The AUC (area under the ROC curve) was 0.63 for FFA levels to distinguish AKI. In primary NS, elevated FFA levels tend to be related to a high risk of AKI. FFAs have diagnostic value and may serve as biomarkers for AKI in NS.

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Section: Discussionmentioning

confidence: 99%

Serum free fatty acid elevation is related to acute kidney injury in primary nephrotic syndrome

Zhang

Cui

et al. 2022

Renal Failure

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“…We recently assessed the plasma proteome through a mass spectrometry-based global proteomics analysis in albumin-deficient mice, and these results indicate that some minor changes occurred in the plasma proteome. Some of the proteins noted in the present review for CAA patients were also upregulated in albumin-deficient mice (apoB, transferrin, RBP, and α-2-HS-glycoprotein) [ 8 ]. It is difficult to compare analyses of globulin classes with mass spectrometry-based proteomics analysis, and the literature on CAA patients is largely based upon globulin class assessment.…”

Section: Discussionmentioning

confidence: 99%

“…In the articles selected for this systematic review, FFA concentrations were not reported. However, one might expect reduced plasma FFA concentration in humans with CAA, as analbuminemic mice (albumin knockout mice) exhibit reduced plasma FFA [ 8 ]. Studying the metabolic effects of decreased FFA in patients would require strict nutritional control, which does not usually occur in case studies.…”

Section: Discussionmentioning

confidence: 99%

“…It is also possible that any detrimental effects of albumin deficiency may be balanced by some metabolically protective changes in lipid metabolism. For example, albumin knockout mice exhibit lower plasma free fatty acid (FFA) abundance than seen in wild-type mice [ 8 ], and this reduction could have some positive effects, as higher plasma FFA concentration is believed to lead to various health complications [ 8 , 9 ]. However, it is also noteworthy that the effects of complete albumin deficiency might include elevation of low density lipoprotein cholesterol (LDL-C) above the reference range; it is difficult to assess the magnitude of this effect, as typically in case reports patients are not directly compared to appropriate control subjects, and they are instead compared to reference ranges for each analyte.…”

Section: Introductionmentioning

confidence: 99%

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Alterations in the Plasma Protein Expression Pattern in Congenital Analbuminemia—A Systematic Review

2023

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Albumin is a highly abundant plasma protein with multiple functions, including the balance of fluid between body compartments and fatty acid trafficking. Humans with congenital analbuminemia (CAA) do not express albumin due to homozygosity for albumin gene mutation. Lessons about physiological control could be learned from CAA. Remarkably, these patients exhibit an apparently normal lifespan, without substantial impairments in physical functionality. There was speculation that tolerance to albumin deficiency would be characterized by significant upregulation of other plasma proteins to compensate for analbuminemia. It is unknown but possible that changes in plasma protein expression observed in CAA are required for the well-documented survival and general wellness. A systematic review of published case reports was performed to assess plasma protein pattern remodeling in CAA patients who were free of other illnesses that would confound interpretation. From a literature search in Pubmed, Scopus, and Purdue Libraries (updated October 2022), concentration of individual plasma proteins and protein classes were assessed. Total plasma protein concentration was below the reference range in the vast majority of CAA patients in the analysis, as upregulation of other proteins was not sufficient to prevent the decline of total plasma protein when albumin was absent. Nonetheless, an impressive level of evidence in the literature indicated upregulated plasma levels of multiple globulin classes and various specific proteins which may have metabolic functions in common with albumin. The potential role of this altered plasma protein expression pattern in CAA is discussed, and the findings may have implications for other populations with hypoalbuminemia.

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“…Energy in the body is primarily stored as triglyceride in adipose tissue. Free fatty acids are induced rapid mobilization into circulation, through triglyceride lipolysis and free fatty acid export from adipose tissue (Abdollahi et al 2022 ). Adams et al (Adams et al 1993 ) reported map the pattern of muscle contractile activity evoked by EMS and revealed that EMS evoked higher muscle contractile activity than voluntary muscle contractile activity.…”

Section: Discussionmentioning

confidence: 99%

Effect of electromyostimulation training on intramuscular fat accumulation determined by ultrasonography in older adults

et al. 2022

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Purpose Electromyostimulation (EMS) induces a short-term change in muscle metabolism, and EMS training induces long-term improvements of muscle atrophy and function. However, the effects of EMS training on intramuscular fat in older adults are still poorly known. The purpose of this study was to examine whether the intramuscular fat index and biochemical parameters change with EMS training of the quadriceps femoris muscles in older adults. Methods Nineteen non-obese older men and women performed EMS training of the quadriceps femoris for 12 weeks (3 times/week; single session for 30 min). The intramuscular fat content index was estimated by echo intensity of the vastus lateralis and rectus femoris muscles on ultrasonography, and muscle thickness was also measured. Muscle strength was assessed as the maximal voluntary contraction during isometric knee extension. Echo intensity, muscle thickness, and muscle strength were measured before and after EMS training. A rested/fasting blood samples were collected before and after EMS training for measuring plasma glucose, insulin, free fatty acid, triglyceride, and interleukin-6 concentrations. To examine the acute effect of a single-EMS session on biochemical parameters, blood samples were taken before and after the EMS session. Results EMS training did not significantly change echo intensity in muscles, muscle thickness, muscle strength, or biochemical parameters. Regarding the acute effect on blood lipid concentrations, a single-EMS session increased free fatty acid and glucose concentrations. Conclusion EMS sessions had an acute effect of increasing free fatty acid and glucose concentrations, but EMS training intervention did not improve intramuscular fat content. Supplementary Information The online version contains supplementary material available at 10.1007/s00421-022-05074-3.

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Albumin knockout mice exhibit reduced plasma free fatty acid concentration and enhanced insulin sensitivity

Cited by 13 publications

References 87 publications

Serum free fatty acid elevation is related to acute kidney injury in primary nephrotic syndrome

Serum free fatty acid elevation is related to acute kidney injury in primary nephrotic syndrome

Alterations in the Plasma Protein Expression Pattern in Congenital Analbuminemia—A Systematic Review

Effect of electromyostimulation training on intramuscular fat accumulation determined by ultrasonography in older adults

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