Albumin Excretion Rate, Serum Insulin-like Growth Factor-I and Glomerular Filtration Rate in Type I Diabetes Mellitus at Puberty

Şen, Alp; Büyükgebiz, Atilla

doi:10.1515/jpem.1997.10.2.209

Cited by 13 publications

(12 citation statements)

References 17 publications

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“…One study found a significant association among IGF-1, renal hypertrophy, and microalbuminuria (19). However, others did not confirm this relationship (104). To date, studies evaluating microalbuminuria during puberty have been cross sectional.…”

Section: Role Of Puberty In Development Of Microalbuminuriamentioning

confidence: 99%

Microalbuminuria as a marker of cardiovascular and renal risk in type 2 diabetes mellitus: a temporal perspective

Lane

2004

American Journal of Physiology-Renal Physiology

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Microalbuminuria is a marker for diabetic nephropathy. It also signifies cardiovascular disease, as well as nephropathy, in type 2 diabetes (DM2). Microalbuminuria may precede DM2, occurring with the insulin resistance syndrome and its components, including obesity and hypertension. Other indicators of cardiovascular risk, such as markers of inflammation, are associated with microalbuminuria in populations of patients with and without diabetes. With the rising prevalence of DM2 in minority youth, especially in Native Americans, a marker for future disease risk would allow earlier prevention strategies to be tested. Before microalbuminuria can be used in a prevention strategy, more needs to be known about the mechanism(s) of the association between elevated excretion, its relationship to glucose intolerance, and its relative contribution to cardiovascular and renal disease. These questions are especially applicable as we begin to observe the long-term complications of diabetes in youth.

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Section: Role Of Puberty In Development Of Microalbuminuriamentioning

confidence: 99%

Microalbuminuria as a marker of cardiovascular and renal risk in type 2 diabetes mellitus: a temporal perspective

Lane

2004

American Journal of Physiology-Renal Physiology

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“…Involvement of GH, either directly or through its effector molecule IGF-I, in the early stages of diabetic nephropathy was suggested in two cross-sectional studies in human type I diabetic patients. In one study, a positive correlation was found between serum IGF-I and glomerular filtration rate 1. In another study, a strong positive correlation between urinary IGF-I and kidney volume and between urinary IGF-I, urinary GH, and microalbuminuria was seen 2.…”

Section: Introductionmentioning

confidence: 94%

Identification of differentially expressed genes in the kidneys of growth hormone transgenic mice

Coschigano

Wetzel

Obichere

et al. 2010

Growth Hormone & IGF Research

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Objective Bovine growth hormone (bGH) transgenic mice develop severe kidney damage. This damage may be due, at least in part, to changes in gene expression. Identification of genes with altered expression in the bGH kidney may identify mechanisms leading to damage in this system that may also be relevant to other models of kidney damage. Design cDNA subtraction libraries, northern blot analyses, microarray analyses and real-time reverse transcription polymerase chain reaction (RT/PCR) assays were used to identify and verify specific genes exhibiting differential RNA expression between kidneys of bGH mice and their non-transgenic (NT) littermates. Results Immunoglobulins were the vast majority of genes identified by the cDNA subtractions and the microarray analyses as being up-regulated in bGH. Several glycoprotein genes and inflammation-related genes also showed increased RNA expression in the bGH kidney. In contrast, only a few genes were identified as being significantly down-regulated in the bGH kidney. The most notable decrease in RNA expression was for the gene encoding kidney androgen-regulated protein. Conclusions A number of genes were identified as being differentially expressed in the bGH kidney. Inclusion of two groups, immunoglobulins and inflammation-related genes, suggests a role of the immune system in bGH kidney damage.

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“…Puberty in particular was associated with a three-fold increase risk of MA independent of any effect on glycaemic control, thus suggesting that the hormonal changes of puberty may be important [33]. Derangements of the GH/IGF-I axis have been associated with increased urinary albumin excretion in T1DM [35,36] and with the development of retinopathy [37].…”

Section: Microvascular Complications Of T1dmmentioning

confidence: 99%

Childhood and Adolescent Diabetes

Regan¹,

Acerini²

2005

IGF-I and IGF Binding Proteins

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Circulating levels of insulin-like growth factor-I (IGF-I) and its principal binding protein IGFBP-3 are reduced, whereas those of the inhibitory binding protein, IGFBP-1, tend to be high in children and adolescents with type 1 diabetes mellitus (T1DM). These abnormalities are thought to arise because of relative portal hypoinsulinaemia and partial resistance at the hepatic growth hormone (GH) receptor. During adolescence, reductions in IGF-I and IGF bioactivity lead to feedback for GH hypersecretion and the elevated GH and low IGF-I levels lead to an increase of the normal insulin resistance encountered during puberty. Low IGF-I levels, but in particular elevated GH levels, have been implicated in the pathogenesis of diabetic microangiopathic complications, in particular, renal hypertrophy, glomerular hyperfiltration and the development of microalbuminuria. Early study of IGF-I replacement with recombinant human IGF-I (rhIGF-I) demonstrated, in the short term, reductions in GH hypersecretion with improved insulin sensitivity and, in the longer term, reductions in insulin requirements and improvements in HbA1c levels. However, larger doses of rhIGF-I were associated with retinopathy either due to rapid improvements in glycaemic control or direct effects of high levels of 'free' IGF-I. More recently, pilot studies using the combination of rhIGF-I/rhIGFBP-3 have confirmed the physiological efficacy of IGF-I replacement in T1DM. The combined treatment is better tolerated and may result in reduced tissue exposure to high levels of 'free' IGF-I. Longer term clinical studies with this IGF-I/IGFBP-3 combination are needed.

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Albumin Excretion Rate, Serum Insulin-like Growth Factor-I and Glomerular Filtration Rate in Type I Diabetes Mellitus at Puberty

Cited by 13 publications

References 17 publications

Microalbuminuria as a marker of cardiovascular and renal risk in type 2 diabetes mellitus: a temporal perspective

Microalbuminuria as a marker of cardiovascular and renal risk in type 2 diabetes mellitus: a temporal perspective

Identification of differentially expressed genes in the kidneys of growth hormone transgenic mice

Childhood and Adolescent Diabetes

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