Albumin Excretion Rate Increases During Acute Myocardial Infarction and Strongly Predicts Early Mortality

Berton, Giuseppe; Citro, Tiziana; Palmieri, Rosa; Petucco, Stefania; Toni, Renzo De; Palatini, Paolo

doi:10.1161/01.cir.96.10.3338

Cited by 85 publications

(71 citation statements)

References 29 publications

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“…When the two groups of AMI patients were stratified into quartiles according to ACR values, the mortality rate ranged from 0% for the nondiabetic AMI patients in the lowest ACR quartile to 73.3% for the diabetic AMI patients in the highest ACR quartile. Our group has previously reported that low-level urinary albumin predicts in-hospital and 1-year mortality in subjects admitted to hospital for AMI [11,12]. The present study is the first to examine the additional prognostic information provided by albuminuria for 3-year mortality over that already available from clinical and instrumental findings in diabetic patients with AMI.…”

Section: Discussionmentioning

confidence: 65%

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Albumin excretion in diabetic patients in the setting of acute myocardial infarction: association with 3-year mortality

Berton¹,

Cordiano²,

Palmieri³

et al. 2004

Diabetologia

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Aims/hypothesis. Diabetes mellitus is associated with increased mortality in subjects with acute myocardial infarction (AMI). We aimed to estimate the risk of mortality in AMI patients with and without diabetes using the urinary albumin : creatinine ratio (ACR).Methods. This is a prospective study of 121 consecutive, non-selected diabetic AMI patients, 121 age-and sex-matched non-diabetic AMI patients and 61 diabetic non-AMI outpatients as control subjects. All data were obtained during the first 7 days of hospitalisation and each AMI patient was followed for a period of exactly 3 years. Baseline ACR RIA measurements were made on the 1st, 3rd and 7th days of admission. Results. Adjusted ACR values were significantly higher in the diabetic AMI patients than in the diabetic control outpatients (p<0.0001), and a significant difference was observed between the weekly ACR slopes for these two groups (p<0.0001). Microalbuminuria was more prevalent in the diabetic AMI patients than in the non-diabetic AMI patients on the 1st day (62% vs 46%, p=0.01) and 3rd day (41% vs 29%, p=0.04). Among the AMI patients with normoalbuminuria (ACR <30 µg/mg), the mortality rate was 11.6% for the patients without diabetes and 33.8% for those with diabetes (p=0.001). The mortality rate was much higher among the AMI patients with microalbuminuria (ACR ≥30 µg/mg) and similar for the diabetic (68.0%) and non-diabetic patients (74.3%). In a multivariable Cox model, ACR (p<0.0001) and diabetes status (p=0.01) were associated with adverse outcome even when several other clinical variables were included in the model. Furthermore, a negative interaction was found between diabetes and ACR (p=0.01). Conclusions/interpretation. Microalbuminuria frequently occurs in diabetic and non-diabetic AMI patients during the first 3 days of admission to hospital and can be used to identify subjects at high risk of mortality.

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Section: Discussionmentioning

confidence: 65%

“…We recently demonstrated that the AER is increased in patients with AMI and it is strongly and independently associated with global and cardiovascular mortality [11,12].…”

Section: Introductionmentioning

confidence: 99%

Albumin excretion in diabetic patients in the setting of acute myocardial infarction: association with 3-year mortality

Berton¹,

Cordiano²,

Palmieri³

et al. 2004

Diabetologia

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show abstract

“…In patients with acute myocardial infarction (AMI) [20][21][22] microalbuminuria has been reported to occur early, yielding prognostic information about in-hospital mortality additional to that provided by clinical or echocardiographic evaluation of left ventricular function. In non-diabetic patients with AMI [23], microalbuminuria has been shown to be a predictor not only for mortality but even for morbidity.…”

Section: Discussionmentioning

confidence: 99%

Prevalence, predictors and prognostic significance of microalbuminuria in acute cardiac patients: a single center experience

et al. 2011

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“…Few studies have indicated that microalbuminuria is common in nondiabetic, nonhypertensive population and is considered to be an independent indicator of cardiovascular risk factors and cardiovascular mortality. (14,15) In clinical practice, a spot-urine sample is collected when the patient visits either the general practitioner or the health care office, where the screening takes place.…”

Section: Issn: 2320-5407mentioning

confidence: 99%

A Clinical Study of Microalbuminuria in Non-Diabetic Coronary Artery Disease Patients in an Industrial Hospital

Tabasum¹,

Bazaz²

2018

IJAR

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Albumin Excretion Rate Increases During Acute Myocardial Infarction and Strongly Predicts Early Mortality

Abstract: These data show that AER increases during AMI and that it yields prognostic information additional to that provided by clinical or echocardiographic evaluation of left ventricular performance.

Cited by 85 publications

References 29 publications

Albumin excretion in diabetic patients in the setting of acute myocardial infarction: association with 3-year mortality

Albumin excretion in diabetic patients in the setting of acute myocardial infarction: association with 3-year mortality

Prevalence, predictors and prognostic significance of microalbuminuria in acute cardiac patients: a single center experience

A Clinical Study of Microalbuminuria in Non-Diabetic Coronary Artery Disease Patients in an Industrial Hospital

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