Albumin Content of Rat Hepatic Cells at Different Levels of Protein Intake

The Influence of Iso-Energetic Amounts of Sucrose and Starch on Serum Albumin Concentrations and Liver Composition of Weanling Rats Given a Low-Protein Diet

“…However, Chandasakharam et al (2) suggested that the synthesis of serum albumin by liver cells had an 'all or nothing' property, as the result of their finding that the number of liver cells containing demonstrable albumin in rats was reduced when the animals consumed a low-protein diet. Furthermore, Rothchild et al (13) have claimed that under normal conditions the liver is only synthesizing albumin to one-third of its capacity to do so.…”

Intracellular Albumin Transport

“…They are also seen in microsomal albumin and a r acid glycoprotein as the synthesis of the former drops and that of the latter rises during the acute phase reaction after induction of inflammation (Fig. (90) Presumably this staining detects albumin in vesicles near the cell membrane, and these vesicles are depleted in cells not forming albumin. Plotting the amount of microsomal albumin content against the rate of albumin synthesis (Fig.…”

“…(90) Prothrombin can be detected in 10-30% of cells; (94) accelerator globulin (Factor V) in 30%. The proportion of cells staining with fluorescent antibodies against a particular protein changes with the rate of synthesis of that protein.…”

The synthesis and secretion of albumin

“…The few histochemical studies have produced conflicting results. Chandrasekharan et al (1967) and Peters et al (1968) observed that the number of liver cells staining for albumin varies with the rate of albumin synthesis, whereas Feldmann et al (1972) found no change in the number of cells. The histochemical findings allow several explanations as discussed by Chandrasekharan et al (1967) and by Feldmann et al (1972)and are, therefore, not conclusive.…”