Albumin-bound paclitaxel and gemcitabine combination therapy in soft tissue sarcoma

Abstract

Background: The evidence that albumin-bound paclitaxel (nab-paclitaxel) is safe and efficacious for the treatment of many types of malignant tumors is continuously increasing. However, the clinical data and evidence of nab-paclitaxel and gemcitabine in metastatic soft tissue sarcoma (STS) treatment are rare.Methods: The data of 17 patients with metastatic STS who received nab-paclitaxel/ gemcitabine chemotherapy between January 2019 and February 2020 were retrospectively reviewed. All patients were treated with nab-paclitaxel/ gemcitabine only after doxorubicin-based chemotherapy had failed. We evaluated the median progression-free survival (m-PFS), disease control rate (DCR), objective response rate (ORR) and adverse events (AEs) in these patients. Results: The m-PFS was 6 months (95% CI, 2–9 months), ORR was 41.2% and DCR was 70.6%. The average change in target lesion diameter from baseline was -19.06±45.74%. While the majority of the treatment patients experienced grade 1 or 2 AEs, grade 3 or 4 AEs were not common, but included neutropenia (17.6%), fatigue (11.8%), anemia (11.8%), leukopenia (11.8%), nausea (5.9%), peripheral neuropathy (5.9%), diarrhea (5.9%), and thrombocytopenia (5.9%). No treatment-related deaths occurred. Conclusion: Nab-paclitaxel/ gemcitabine combination chemotherapy is comparatively effective in the treatment of STS, demonstrates low toxicity, and is worthy of further study.

Successful Treatment of a Locally Recurrent and Metastatic Malignant Phyllodes Tumor with Accelerated Radiotherapy and Nab-Paclitaxel, Cisplatin, and Liposomal Doxorubicin Chemotherapy

“…A recent molecular analysis with next-generation sequencing, however, suggests that phyllodes tumors present several markers of sensitivity to taxanes and, especially, for nab-paclitaxel [20]. Nab-paclitaxel/gemcitabine regimen has recently been used for the treatment of soft tissue sarcomas, showing acceptable efficacy and good tolerance [21]. In carcinosarcomas of the uterus, a combination of cisplatin with paclitaxel is considered the most active combination [22].…”

Apatinib with doxorubicin and ifosfamide as neoadjuvant therapy for high-risk soft tissue sarcomas: a retrospective cohort study

“…The first-line treatment for advanced (locally unresectable or metastatic) STS is chemotherapy with doxorubicin [3]. The overall response rate (ORR) to this treatment for advanced STS is approximately 20% [5], and the 5-year survival rate among patients with advanced STS treated with a combination regimen is < 10% [6]. These findings suggest the need for an approach that may help reduce the rates of recurrence and metastasis in patients with early-and mid-stage STS.…”