Albumin as a prognostic marker of 30-day mortality in septic patients admitted to the emergency department

The relationship between lactate dehydrogenase to albumin ratio and all-cause mortality during ICU stays in patients with sepsis: A retrospective cohort study with propensity score matching

“…It is well-documented that sepsis triggers tissue damage through inflammatory mechanisms, ensuing organ dysfunction, and an immunosuppressed state. LDH is promptly released into the circulation following tissue injury due to ischemia and hypoxia, highlighting its role as a sensitive marker for cellular damage [ 32 ].Additionally, serum albumin possesses anti-inflammatory characteristics and confers protection against sepsis [ 33 ].An elevated LDH/ALB ratio suggests either a rise in LDH or a decline in albumin, indicating a systemic imbalance and serving as a prognostic indicator in sepsis. Within the realm of clinical practice, extremely high levels of LDH alongside markedly low levels of albumin often signal the critical state of patients, correlating with a substantially high and stable mortality risk.…”