Albumin and gamma-globulin tracer studies in protein depletion states.

Hoffenberg, R.; Black, E. G.; Brock, J. F.

doi:10.1172/jci105319

Cited by 131 publications

(46 citation statements)

References 27 publications

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“…The malnourished children had a statistically lower fractional and absolute catabolic rate than recovered children. This agreed with previous observations in children and hypoalbuminaemic adults (2,3,5). The published studies show a low catabolic rate in malnourished children when given either a high or a low protein diet.…”

Section: Discussionsupporting

confidence: 93%

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Albumin metabolism: effect of the nutritional state and the dietary protein intake

James¹,

Hay²

1968

J. Clin. Invest.

176

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A B S T R A C T Nine malnourished and nine children who had recovered from malnutrition were given a single injection of albumin-131I and were studied during consecutive periods in which the dietary protein was changed.Malnourished children had significantly lower catabolic rates of albumin than had recovered children on the same protein intake. Both nutritional groups, however, showed a progressive fall in catabolic rate after 3-5 days on a low protein diet (0.7-1.0 g/kg per day), and the maximum effect was seen in the 2nd wk of low protein feeding. The catabolic rate could return to normal within 3 wk in a malnourished child fed 4 g of protein/kg per day.The albumin synthetic rate was measured by a computer technique suitable for nonsteady-state conditions. The synthetic rate in the malnourished groups (101 mg/kg per day) fed on a low protein diet was significantly lower than the rate in the recovered groups (148 mg/kg per day). The synthetic rate responded rapidly to a change in diet; when the rate fell, the intravascular albumin mass was maintained by two compensating mechanisms: (1) a net transfer of extravascular albumin into the intravascular pool; and (2) by a delayed fall in the catabolic rate. The net transfer of albumin into the intravascular compartment diminished as the catabolic rate fell.Adaptation to a low protein diet was associated with: (a) low synthetic and catabolic rates of albumin; (b) a reduced extravascular albumin mass;

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Section: Discussionsupporting

confidence: 93%

“…Animal and human studies of albumin metabolism in protein depletion have been concerned largely with the assessment of the catabolic rate of albumin and the extent to which it changes in the depleted subject or animal (1)(2)(3)(4)(5).…”

Section: Introductionmentioning

confidence: 99%

Albumin metabolism: effect of the nutritional state and the dietary protein intake

James¹,

Hay²

1968

J. Clin. Invest.

176

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“…Specific toxic effects of alcohol, therefore, probably played some role in depressing and altering albumin production since all the patients were studied within days of admission. Nitrogen and amino acid intake and amino acid levels within the cell are important (32)(33)(34)(35)(36). Studies with albumin-'I indicate a marked decrease in synthesis in patients on deficient caloric diets.…”

Section: Discussionmentioning

confidence: 99%

“…Change in colloid osmotic pressure, pressure alterations within the liver, thyroid and cortisone metabolism, as well as changes in the nutritional state, all could influence albumin synthesis (29,32,33,(38)(39)(40)(41)(42)(43)(44).…”

Section: Discussionmentioning

confidence: 99%

Albumin synthesis in cirrhotic subjects with ascites studied with carbonate-14C

Rothschild¹,

Oratz²,

Zimmon³

et al. 1969

J. Clin. Invest.

139

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“…Albumin synthesis has been found to be reduced in malnutrition (1)(2)(3)(4) and these changes have been ascribed to a deficiency of available amino acids (3,4). A decrease in polysomal size, as well as a more rapid turnover of RNA (5,6), has been reported in the livers of fasted rats, and Marsh who has shown that perfused rat liver from a fasted rabbit made less protein ascribed this result to a deficient supply of glycogen (7).…”

Section: Introductionmentioning

confidence: 99%

Effects of a short-term fast on albumin synthesis studied in vivo, in the perfused liver, and on amino acid incorporation by hepatic microsomes

Rothschild¹,

Oratz²,

Mongelli³

et al. 1968

J. Clin. Invest.

124

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AB S TRA CT Carbonate-14C was used to label the hepatic intracellular arginine pool and direct measurement of albumin synthesis was made in six rabbits before and after an 18-36 hr fast. 18 perfusion studies were performed with livers derived from fed and fasted rabbits (18-24 hr). Microsomal amino acid-incorporating ability with leucine-MH and phenylalanine-14C was compared in 17 studies, using microsomes isolated from livers taken from fed and fasted rabbits and from isolated perfused livers whose donors were fed and fasted.Albumin synthesis is rapidly inhibited by fasting. Albumin synthesis decreased 337%o in vivo and 53%o in the perfused liver. The microsomes from perfused livers taken from fed animals did not demonstrate a significantly reduced capacity to incorporate leucine-3H or phenylalanine-'4C into protein. Microsomes derived from perfused and nonperfused livers whose donors were fasted incorporated 32-54%o less tracer than microsomes obtained from fed donor rabbits. Microsomes separated from perfused livers removed from fed and fasted rabbits responded to polyuridylic acid stimulation and phenylalanine-14C incorporation rose from 58 to 171%. An 18-36 hr fast inhibits albumin production in vivo and in the perfused liver. The microsomal

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Albumin and gamma-globulin tracer studies in protein depletion states.

Cited by 131 publications

References 27 publications

Albumin metabolism: effect of the nutritional state and the dietary protein intake

Albumin metabolism: effect of the nutritional state and the dietary protein intake

Albumin synthesis in cirrhotic subjects with ascites studied with carbonate-14C

Effects of a short-term fast on albumin synthesis studied in vivo, in the perfused liver, and on amino acid incorporation by hepatic microsomes

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