Albumin and colloid osmotic pressure

Odunayo, Adesola

doi:10.1002/9781118923870.ch4

Cited by 2 publications

(1 citation statement)

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“…Low serum albumin leads to reduced collagen synthesis and granuloma formation, thereby impairing the innate immune response. This causes slowed wound healing and a tendency to infection (Odunayo, 2016). In addition to this study the group of burn patients who had hypoalbuminemia had a higher mean TBSA than the group without hypoalbuminemia (p<0.001).…”

Section: Discussionmentioning

confidence: 62%

A Retrospective Study on the Factors Affecting Patients Length of Stay at the Burn Center RSUD Dr. Soetomo Surabaya During 2017-2019

Pramana¹,

Handriani²,

Rizaliyana³

2023

IJRP

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Background: Length of stay (LOS) is one of contributor in hospital costs, and attention has been paid to reducing LOS without compromising the quality of care for patients. Hospitals with a burn center have a longer average LOS than hospitals without a burn center, which can result in higher hospitalization costs. This study aims to identify the epidemological and clinical factors that affect LOS in burn patients. Methods:We conducted a retrospective cross-sectional study in design included all patients admitted to the Burn Center Soetomo General Hospital Surabaya between January 2017 -December 2019 who arrived within 48 hours after injury and survived till discharge. Patients who arrived after 48 hours following the injury, death during treatment and discharge against medical advice are excluded. Epidemiological and clinical data, such as age, gender, pre-existing co-morbidities, total body surface area (TBSA) burn wound, depth of burn, inhalation trauma, burn etiology, hospital acquired pneumonia (HAP), sepsis, anemia and hypoalbuminemia collected and subjected to statistical analysis.Results: Of all 249 patients admitted, 136 patients are eligible in the inclusion criteria. Median LOS in the total population was 17 days. The population most often treated for more than 28 days is a patient with a burn area of 30.5-40%, experiencing HAP and hypoalbuminemia. LOS significantly increased with TBSA, inhalation trauma, comorbidities, HAP, sepsis, anemia and hypoalbuminemia. Conclusion:There are several factors associated with the increased LOS observed in burn patients. This study confirmed and identified new factors that were significantly associated with LOS and were not previously discussed in the literature which allows better prediction of LOS and management of patients with burn injuries.

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Section: Discussionmentioning

confidence: 62%

A Retrospective Study on the Factors Affecting Patients Length of Stay at the Burn Center RSUD Dr. Soetomo Surabaya During 2017-2019

Pramana¹,

Handriani²,

Rizaliyana³

2023

IJRP

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Response differences of HepG2 and Primary Mouse Hepatocytes to morphological changes in electrospun PCL scaffolds

Bate

Gadd

Forbes

et al. 2021

Sci Rep

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Liver disease cases are rapidly expanding across the globe and the only effective cure for end-stage disease is a transplant. Transplant procedures are costly and current supply of donor livers does not satisfy demand. Potential drug treatments and regenerative therapies that are being developed to tackle these pressing issues require effective in-vitro culture platforms. Electrospun scaffolds provide bio-mimetic structures upon which cells are cultured to regulate function in-vitro. This study aims to shed light on the effects of electrospun PCL morphology on the culture of an immortalised hepatic cell line and mouse primary hepatocytes. Each cell type was cultured on large 4–5 µm fibres and small 1–2 µm fibres with random, aligned and highly porous cryogenically spun configurations. Cell attachment, proliferation, morphology and functional protein and gene expression was analysed. Results show that fibre morphology has a measurable influence on cellular morphology and function, with the alteration of key functional markers such as CYP1A2 expression.

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Albumin and colloid osmotic pressure

Cited by 2 publications

References 64 publications

A Retrospective Study on the Factors Affecting Patients Length of Stay at the Burn Center RSUD Dr. Soetomo Surabaya During 2017-2019

A Retrospective Study on the Factors Affecting Patients Length of Stay at the Burn Center RSUD Dr. Soetomo Surabaya During 2017-2019

Response differences of HepG2 and Primary Mouse Hepatocytes to morphological changes in electrospun PCL scaffolds

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